Results 71 to 80 of about 25,536 (213)

Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells

Cell Communication and Signaling, 2019
Background Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αvβ3 integrin and VEGF type 2 receptor (VEGFR2)
Taís M. Danilucci, Patty K. Santos, Bianca C. Pachane, Graziéle F. D. Pisani, Rafael L. B. Lino, Bruna C. Casali, Wanessa F. Altei, Heloisa S. Selistre-de-Araujo   +7 more
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Integrin αvβ3 and thyroid hormones promote expansion of progenitors in embryonic neocortex. [PDF]

, 2014
Neocortex expansion during evolution is associated with the enlargement of the embryonic subventricular zone, which reflects an increased self-renewal and proliferation of basal progenitors.
Wilsch-Bräuninger, M., Wong, FK; id_orcid, Huttner, WB, Stenzel, D., Wong, F., Huttner, W., Wilsch-Bräuninger, M, Heuer, H, Heuer, H., Stenzel, D   +9 more
core   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

CCL2 increases αvβ3 integrin expression and subsequently promotes prostate cancer migration [PDF]

, 2013
[[abstract]]BACKGROUND: Chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), belongs to the CC chemokine family which is associated with the disease status and outcomes of cancers.
Tien-Huang, L;Lin, Tien-Huang;Liu, Hsin-Ho;Liu, Hsin-Ho;Tsung-Hsun, T;Tsai, Tsung-Hsun;Ch, Chi-Cheng;Chen, Chi-Cheng;Hsie, Teng-Fu;Hsieh, Teng-Fu;Le, Shang-Sen;Lee, Shang-Sen;Lee, Yuan-Ju;Lee, Yuan-Ju;Chen, Wen-Chi;Chen, Wen-Chi;湯智昕;Chih-Hsin, Tang
core  

Recent advances and clinical applications of 3D printing for female reproductive organ regeneration and gynecological disease

Interdisciplinary Medicine, EarlyView.
This comprehensive review highlights the transformative role of 3D printing and bioprinting technologies in the regeneration of female reproductive organs and the treatment of gynecological diseases. Unlike previous overviews that focus narrowly on isolated applications, this work provides an integrative analysis of recent clinical and preclinical ...
Chan Hum Park, In‐Sun Hong
wiley   +1 more source

Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells [PDF]

, 2013
Many bio-pharmaceutical production processes are based upon the use of mammalian cell lines, such as Chinese hamster ovary (CHO) cells, capable of proliferation as single cells in suspension in a synthetic environment.
Walther, Christa G
core  

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

ATM-Mediated DNA Damage Signals Mediate Immune Escape through Integrin-αvβ3-Dependent Mechanisms [PDF]

, 2012
Although recent evidences have been unveiling the critical role of tumor microenvironments in tumor progression and metastasis, it remains unclear how resistance to various anticancer modalities is linked with the modulation of tumor microenvironments ...
Hironori Yoshiyama, Koyu Ito, Jinushi, Masahisa, Ito, Koyu, Uede, Toshimitsu, Muhammad Baghdadi, Kinoshita, Ichiro, Yagita, Hideo, Toshimitsu Uede, Masahisa Jinushi, Hirotoshi Dosaka-Akita, Akinori Takaoka, Hideo Yagita, Baghdadi, Muhammad, Dosaka-Akita, Hirotoshi, Chiba, Shigeki, Takaoka, Akinori, Shigeki Chiba, Ichiro Kinoshita, Yoshiyama, Hironori   +19 more
core   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source