Results 41 to 50 of about 23,065 (117)

Interaction between CD82 and integrin αVβ3 selectively regulates collective movement of tumor cells via endolysosomal trafficking

Cellular and Molecular Life Sciences
Tetraspanin CD82/KAI1 inhibits cell movement and metastasis of malignant tumors, and reduced and lost expressions of CD82 predict worse outcomes of patients with malignant tumors.
Xue Jun Wang, Mekel M. Richardson, Yingjun Ding, Chao Jiang, Songlan Liu, Bin Zhou, Shuping Li, Junxiong Chen, Eric Rubinstein, Franklin A. Hays, Kamiya Mehla, Xin A. Zhang   +11 more
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In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

EJNMMI Research, 2019
Background Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ life quality.
Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier, Melanie A. Kimm   +9 more
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Integrin αVβ3 Function Influences Citalopram Immobility Behavior in the Tail Suspension Test

Frontiers in Neuroscience, 2019
Human studies first identified genetic and expression interactions between integrin β3 and serotonin (5-HT) transporter (SERT) genes. This association has been further strengthened by our discovery that integrin β3-containing receptors (αvβ3) physically ...
Hope Pan, Michael R. Dohn, Rody Kingston, Ana M. D. Carneiro   +3 more
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Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin αvβ3 signaling pathway

Scientific Reports, 2022
Gadolinium (Gd)-based contrast agents (GBCAs) are chemicals injected intravenously during magnetic resonance imaging to enhance the diagnostic yield. Repeated use of GBCAs causes their deposition in the brain.
Winda Ariyani, Wataru Miyazaki, Yoshito Tsushima, Noriyuki Koibuchi   +3 more
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Nano Diaminopropane tetrac and integrin αvβ3 expression in different cancer types: Anti-cancer efficacy and Safety

Cancer Treatment and Research Communications, 2021
Integrins are a family of heterodimeric plasma membrane glycoproteins, which regulate tumor growth, angiogenesis, migration, and metastasis. Integrin αvβ3 has been recognized as a putative target for the treatment of several cancers.
Kavitha Godugu, Thangirala Sudha, Paul J. Davis, Shaker A. Mousa   +3 more
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Integrin-targeted quantitative optoacoustic imaging with MRI correlation for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. [PDF]

PLoS ONE, 2018
PURPOSE:To investigate αvβ3-integrin-targeted optoacoustic imaging and MRI for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. MATERIALS AND METHODS:Human BRAF V600E-positive melanoma xenograft (A375)-bearing Balb/
Philipp M Kazmierczak, Neal C Burton, Georg Keinrath, Heidrun Hirner-Eppeneder, Moritz J Schneider, Ralf S Eschbach, Maurice Heimer, Olga Solyanik, Andrei Todica, Maximilian F Reiser, Jens Ricke, Clemens C Cyran   +11 more
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Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery

ChemistryOpen, 2019
RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers.
Adina Borbély, Dr. Eduard Figueras, Ana Martins, Dr. Lizeth Bodero, Dr. André Raposo Moreira Dias, Dr. Paula López Rivas, Dr. Arianna Pina, Dr. Daniela Arosio, Dr. Paola Gallinari, Dr. Marcel Frese, Dr. Christian Steinkühler, Prof. Dr. Cesare Gennari, Prof. Dr. Umberto Piarulli, Prof. Dr. Norbert Sewald   +13 more
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Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress

Cell Communication and Signaling, 2023
Background Integrins are closely related to mechanical conduction and play a crucial role in the osteogenesis of human mesenchymal stem cells. Here we wondered whether tensile stress could influence cell differentiation through integrin αVβ3.
Yan Peng, Rongmei Qu, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Wenqing Liu, Jinhui Zhu, Junxin Chen, Xiaoqing Li, Jingxing Dai, Jun Ouyang   +12 more
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Sca-1 is involved in the adhesion of myosphere cells to αVβ3 integrin

Biology Open, 2012
Summary A myosphere cell is a unique type of muscle stem cell that is able to maintain its pre-myogenic state in culture over time. These cells are propagated in culture as free-floating, non-adherent spheres.
Ashley Penvose, Karen A. Westerman
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Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography

Journal of Translational Medicine, 2017
Background Radiolabeled RGD peptides detect αvβ3 integrin expression associated with angiogenesis and extracellular matrix remodeling after myocardial infarction. We studied whether cardiac positron emission tomography (PET) with [68Ga]NODAGA-RGD detects
Maria Grönman, Miikka Tarkia, Tuomas Kiviniemi, Paavo Halonen, Antti Kuivanen, Timo Savunen, Tuula Tolvanen, Jarmo Teuho, Meeri Käkelä, Olli Metsälä, Mikko Pietilä, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen, Antti Saraste   +15 more
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