Results 41 to 50 of about 25,536 (213)

Implications of αvβ3 Integrin Signaling in the Regulation of Ca2+ Waves and Myogenic Tone in Cerebral Arteries [PDF]

, 2015
Objective: The myogenic response is central to blood flow regulation in the brain. Its induction is tied to elevated cytosolic [Ca(2+)], a response primarily driven by voltage-gated Ca(2+) channels and secondarily by Ca(2+) wave production.
Sancho González, María, Brett Suzanne E., Zechariah Anil, Donald G. Welsh, Mufti Rania E., Mazumdar Neil   +5 more
core   +1 more source

Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance [PDF]

, 2023
International audienceAbstract Medulloblastoma is one of the most prevalent solid tumors found in children, occurring in the brain's posterior fossa. The standard treatment protocol involves maximal resection surgery followed by craniospinal irradiation ...
Villeneuve, Rémy, Blanchard, Thays, Faraggi, Marc, Broisat, Alexis, Raes, Florian, Picco, Vincent, Echavidre, William, Durivault, Jérôme, Serrano, Benjamin, Pagnuzzi, Marina, Garnier, Nicolas, Montemagno, Christopher, Ortholan, Cécile, Gotorbe, Célia, Vial, Valérie, Amblard, Régis   +15 more
core   +1 more source

Nanoplatforms for Sentinel and Tumor‐Draining Lymph Node Mapping: From Visualization to Pathway‐Informed Staging

Advanced Healthcare Materials, EarlyView.
Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen, Nina Li, Meiyan Zou, Zihao Zhou, Rongwei Xu, Weiyao Feng, Xinyuan Zhao, Li Cui   +7 more
wiley   +1 more source

Epithelial membrane protein-2 regulates surface expression of αvβ3 integrin in the endometrium [PDF]

, 2005
The four-transmembrane protein epithelial membrane protein-2 (EMP2) was recently identified as an endometrial protein necessary for blastocyst implantation, but the mechanism of this role is uncertain.
Williams, Carmen J., Wadehra, Madhuri, Forbes, Ashley, Pushkarna, Natasha, Goodglick, Lee, Braun, Jonathan, Gordon, Lynn K.   +6 more
core   +1 more source

Targeting integrin αVβ3–Ptgs2–mTOR signaling rescues bone formation in osteoporosis: from molecular mechanism toward therapy

Cellular & Molecular Biology Letters
Background Integrin αVβ3, a key ECM receptor, is essential for bone metabolism, yet its role in postmenopausal osteoporosis (PMOP) remains unclear. This study investigates the molecular mechanisms by which integrin αVβ3 regulates osteoblast function and ...
Changshun Chen, Jinyi Gu, Chenhui Yang, Fei Yang, Zirui Liu, Lei Wen, Rongjing Chen, Bin Geng, Yayi Xia   +8 more
doaj   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

EJNMMI Research, 2019
Background Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ life quality.
Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier, Melanie A. Kimm   +9 more
doaj   +1 more source

Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer

BMC Cancer, 2022
Background Integrin αvβ3 has been proposed as crucial determinant for tumor sustained progression and a molecular marker for the estimation of tumor angiogenesis.
Wen Zhou, Junjun Ma, Lifeng Meng, Dabei Liu, Jun Chen   +4 more
doaj   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Activated tumor cell integrin αVβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream. [PDF]

, 2016
Metastasis is the main cause of death in cancer patients, and understanding mechanisms that control tumor cell dissemination may lead to improved therapy. Tumor cell adhesion receptors contribute to cancer spreading. We noted earlier that tumor cells can
Tschan, Mario, Torbett, Bruce E, Weber, Martin R, Krueger, Joseph S, Quigley, James P, Marchese, Patrizia, Weber, MR, Ruggeri, Zaverio M, Felding, BH, Zuka, M, Zuka, Masahiko, Zijlstra, A, Zijlstra, Andries, Eliceiri, BP, Staflin, Karin, Lorger, Mihaela, Staflin, K, Tschan, M, Krueger, JS, Rugerri, ZM, Lorger, M, Felding, Brunhilde H, Quigley, JP, Marchese, P, Eliceiri, Brian P, Torbett, BE   +25 more
core   +1 more source