Results 101 to 110 of about 34,901 (267)

Altered Pathogen Spectrum of Spontaneous Bacterial Peritonitis in Patients Treated With Proton Pump Inhibitors

Alimentary Pharmacology &Therapeutics, EarlyView.
This multicenter, observational study reveals distinct alterations in the microbial spectrum of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor use. These results are especially relevant for guiding empiric antibiotic therapy of SBP.
Philip Kitchen, Sarah L. Schütte, Tammo L. Tergast, Benjamin Maasoumy, Leonie Braun, Ulrich vor dem Esche, Georg Häcker, Marcus M. Mücke, Marlene Reincke, Michael Schultheiss, Robert Thimme, Siegbert Rieg, Dominik Bettinger, Lukas Sturm   +13 more
wiley   +1 more source

Targeting Class A and C Serine \u3b2-Lactamases with a Broad-Spectrum Boronic Acid Derivative [PDF]

, 2014
Production of \u3b2-lactamases (BLs) is the most widespread resistance mechanism adopted by bacteria to fight \u3b2-lactam antibiotics. The substrate spectrum of BLs has become increasingly broad, posing a serious health problem. Thus, there is an urgent
Alberto Venturelli, Bebrone C., Bennett P. M., Blizzard T. A., Bonnefoy A., Bonnet R., Bradshaw J. M., Brian K. Shoichet, Brunger A. T., Bush K., Bush K., Carter P. J., Cecilia Pozzi, Chaibi E. B., Chen Y., Chen Y., Coleman K., Delmas J., Donatella Tondi, Drawz S. M., Ehmann D. E., Emsley P., Farina D., Hirsch E. B., Hunter C. A., Ibuka A., Jacoby G. A., Kettner C. A., Laskowski R. A., Lovell S. C., Majumdar S., Marciano D. C., Maria Paola Costi, Morandi F., Murshudov G. N., Ness S., Nichols D. A., Otwinowski Z. M., Pages J. M., Potterton E., Powers R. A., Powers R. A., Richard Bonnet, Robin F., Roth T. A., Strynadka N. C., Strynadka N. C. J., Strynadka N. C. J., Thornton J. M., Tondi D., Tondi D., Usher K., Venturelli A., Waley S. G., Wang X., Wang X., Wang X., Willcockson I. U., Winn M. D.   +58 more
core   +3 more sources

Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis

BJU International, EarlyView.
Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon, Asaad Ahmad, Natalie Lott, Alison Blatt   +3 more
wiley   +1 more source

Synthesis and Bioactivity of Thiazolethioacetamides as Potential Metallo-β-Lactamase Inhibitors

Antibiotics, 2020
Metallo-β-lactamase (MβLs) mediated antibiotic resistance seriously threatens the treatment of bacterial diseases. Recently, we found that thioacetamides can be a potential MβL inhibitor skeleton. In order to improve the information of the
Yi-Lin Zhang, Yong Yan, Xue-Jun Wang, Ke-Wu Yang   +3 more
doaj   +1 more source

Retraction and replacement: Phenotypes, genotypes and breakpoints: an assessment of β-lactam/β-lactamase inhibitor combinations against OXA-48 [PDF]

, 2023

openalex   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

In vitro activity of cefepime/zidebactam (WCK 5222) against Gram-negative bacteria [PDF]

, 2017
Background: Diazabicyclooctanes (DBOs) inhibit class A, class C and some class D β-lactamases. A few also bind PBP2, conferring direct antibacterial activity and a β-lactamase-independent ‘enhancer' effect, potentiating β-lactams targeting PBP3.
Livermore, David M, Mushtaq, Shazad, Vickers, Anna, Warner, Marina, Woodford, Neil   +4 more
core   +1 more source

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) 2025 guidelines for surgical antimicrobial prophylaxis in dogs and cats

Journal of Small Animal Practice, EarlyView.
Surgical antimicrobial prophylaxis involves the administration of antimicrobials to reduce the risk of a surgical site infection and represents a significant proportion of all antimicrobial use in cats and dogs. This evidence‐based, European Network for Optimization of Veterinary Antimicrobial Therapy guideline provides recommendations for both peri ...
F. Allerton, T. M. Sørensen, K. Scahill, J. E. Ruperez, F. Swinbourne, D. R. Verwilghen, M. C. Nolff, F. Foroutan, S. J. Baines, A. Vilen, L. Pelligand, E. M. Broens, P. L. Toutain, M. L. Brennan, T. Mooney, S. Clarke, J. E. Miles, J. L. Granick, Y. Winsborg, L. R. Jessen, J. S. Weese, on behalf of the European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines and the ESCMID Study Group for Veterinary Microbiology (ESGVM)   +21 more
wiley   +1 more source

Expression of ESBL, MBL and AmpC B lactamases by extra intestinal Escherichia coli isolates: correlation with treatment and clinical outcome

Journal of Microbiology and Infectious Diseases, 2013
Objective: We investigated the expression of Extended Spectrum β-Lactamases (ESBLs), AmpC β lactamases and Carbapenemases in extraintestinal pathogenic Escherichia coli (ExPEC) isolates and correlated with treatment and outcome of the patients.Methods ...
Arindam Chakraborty, Prabha Adhikari, Shalini Shenoy, Shrikala Baliga, Satish Rao, Dhanashree B, Vishwas Saralaya   +6 more
doaj   +1 more source

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes [PDF]

, 2016
Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs ...
Bonomo, Robert A., Castillo, Valerie, Gonzalez, Javier M., Gonzalez, Mariano M., Hinchliffe, Philip, Kosmopoulou, Magda, Llarrull, Leticia, Mahler, Graciela, Mojica, Maria F., Saiz, Cecilia, Spencer, Jim, Tooke, Catherine, Villa, Alejandro J.   +12 more
core   +3 more sources