Results 111 to 120 of about 34,901 (267)

Development of a Whole-Cell Biosensor for β-Lactamase Inhibitor Discovery [PDF]

, 2023
Mitchell A Jeffs, Rachel A. V. Gray, Prameet M. Sheth, Christopher T. Lohans   +3 more
openalex   +1 more source

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

identifying allosteric networks to fight antibiotics resistance [PDF]

, 2018
The rise of multi-drug resistance in bacterial pathogens is one of the grand challenges facing medical science. A major concern is the speed of development of β-lactamase-mediated resistance in Gram-negative species, thus putting at risk the efficacy of ...
Afsharikho, Hamidreza, Barnes, Melissa D., Bonomo, Robert A., Galdadas, Ioannis, Gervasio, Francesco L., Haider, Shozeb, Healy, Jess, Lovera, Silvia, Pérez-Hernández, Guillermo, Woodford, Neil   +9 more
core   +1 more source

Proposed Meropenem Breakpoints for Interpretation of Antimicrobial Susceptibility Testing of Bacteria Isolated From Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Meropenem is a carbapenem antibiotic used infrequently in veterinary medicine. However, antimicrobial susceptibility testing standards are needed to monitor for resistance caused by carbapenem resistant Enterobacterales (CRE). The Clinical and Laboratory Standards Institute (CLSI) does not have veterinary‐specific carbapenem breakpoints for ...
Mark G. Papich, Marilyn N. Martinez
wiley   +1 more source

Postβ-Lactamase-Inhibiting Effect of Sulbactam in Combination with Ceftriaxone on Extended-Spectrum-β-Lactamase-Producing Escherichia coli

Antibiotics
Background/Objectives: Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli poses a significant global health challenge, as it leads to antimicrobial treatment failure and is associated with elevated mortality rates.
Ru Wang, Kun Mi, Aihua Lu, Chengyang Zhang, Lei Sun, Yuxiang Chen, Yuanhu Pan, Yanfei Tao, Lingli Huang   +8 more
doaj   +1 more source

Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution [PDF]

, 2014
The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able ...
Llarrull, Leticia Irene, Meini, María Rocío, Vila, Alejandro Jose   +2 more
core   +3 more sources

Therapeutic Strategies and Clinical Outcomes of Infections Following Anterior Cruciate Ligament Reconstruction: A Narrative Review

Orthopaedic Surgery, EarlyView.
ACL reconstruction‐associated infections threaten graft integrity and joint function. This review summarizes patient‐related risk factors, approaches, and treatment strategies, with emphasis on early recognition and preventive measures such as vancomycin presoaking.
Shaoli Zhang, Jue Gong
wiley   +1 more source

Perturbation of Pseudomonas aeruginosa peptidoglycan recycling by anti-folates and design of a dual-action inhibitor

mBio
Peptidoglycan (PG) is an important bacterial macromolecule that confers cell shape and structural integrity, and is a key antibiotic target. Its synthesis and turnover are carefully coordinated with other cellular processes and pathways.
Luke N. Yaeger, David Sychantha, Princeton Luong, Shahrokh Shekarriz, Océane Goncalves, Annamaria Dobrin, Michael R. Ranieri, Ryan P. Lamers, Hanjeong Harvey, George C. diCenzo, Michael Surette, Jean-Phiippe Côté, Jakob Magolan, Lori L. Burrows   +13 more
doaj   +1 more source

Effect of a β-lactamase inhibitor, tazobactam, on growth and penicillin-binding proteins ofBorrelia burgdorferi [PDF]

FEMS Microbiology Letters, 1991
Carl Urban, James J. Rahal, Benjamin Luft   +2 more
openaire   +1 more source

The Metallo-β-lactamase GOB Is a Mono-Zn(II) Enzyme with a Novel Active Site [PDF]

, 2007
Metallo-β-lactamases (MβLs) are zinc-dependent enzymes able to hydrolyze and inactivate most β-lactam antibiotics. The large diversity of active site structures and metal content among MβLs from different sources has limited the design of a pan-MβL ...
Bennett, Brian, Carloni, Paolo, Costello, Alison L., Gonzalez, Javier M., Limansky, Adriana S., Lisa, Mariá Natalia, Morrán-Barrio, Jorgelina, Peraro, Matteo Dal, Tierney, David L., Viale, Alejandro M., Vila, Alejandro J.   +10 more
core   +1 more source