Results 121 to 130 of about 34,901 (267)

AmpC β-lactamase induction by avibactam and relebactam [PDF]

, 2017
Background: Diazabicyclooctanes, e.g. avibactam and relebactam, are a new class of β-lactamase inhibitors. Their spectrum includes AmpC enzymes, but it is important to understand whether they also induce these enzymes.
Jamrozy, Dorota, Livermore, David M, Mushtaq, Shazad, Nichols, Wright W, Woodford, Neil, Young, Katherine   +5 more
core   +1 more source

Quantitative analyses of empirical fitness landscapes

, 2012
The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects of evolutionary processes and guidance for the study of evolution.
de Visser, J. Arjan G. M., Franke, Jasper, Krug, Joachim, Schenk, Martijn F., Szendro, Ivan G.   +4 more
core   +2 more sources

Potential of high-dose cefepime/tazobactam against multi-resistant Gram-negative pathogens [PDF]

, 2017
Background: Early β-lactamase inhibitors were combined with established penicillins, but different combinations may be more appropriate to counter current β-lactamase threats, with development facilitated by the US Generating Antibiotic Incentives Now ...
Livermore, David M, Mushtaq, Shazad, Turner, Simon J, Warner, Marina, Woodford, Neil   +4 more
core   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Detection of Multi-drug Resistant \u3cem\u3eEscherichia coli\u3c/em\u3e in the Urban Waterways of Milwaukee, WI [PDF]

, 2015
Urban waterways represent a natural reservoir of antibiotic resistance which may provide a source of transferable genetic elements to human commensal bacteria and pathogens. The objective of this study was to evaluate antibiotic resistance of Escherichia
Ahuja, Neha H., DeNies, Maxwell S., Hristova, Krassimira R., Kappell, Anthony D., Ledeboer, Nathan A., Newton, Ryan J.   +5 more
core   +1 more source

Clinical efficacy of β-lactam/β-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum β-lactamase-producing Enterobacteriaceae in haematological patients with neutropaenia: a study protocol for a retrospective observational study (BICAR) [PDF]

, 2017
Introduction: Bloodstream infection (BSI) due to extended-spectrum β-lactamase-producing Gram-negative bacilli (ESBL-GNB) is increasing at an alarming pace worldwide.
Abdala, Edson, Akova, Murat, BICAR Study Group, Cano Yuste, Ángela, Carratalà, Jordi, Cervera, Carlos, Clemente, W.T., Freifeld, A., Gottlieb, T., Gudiol González, Carlota, Gurguí, Mercè, Gómez, L., Herrera, F., Maestro de la Calle, Guillermo, Manzur, Adriana, Martín-Dávila, Pilar, Maschmeyer, G., Meije, Y., Montejo, Miguel, Peghin, Maddalena, Rodríguez Baño, Jesús, Royo-Cebrecos, Cristina, Ruiz, Isabel (Ruiz Camps), Sukiennik, T. C., Tebé, Cristian, Álvarez, R.   +25 more
core   +3 more sources

From Lake Victoria to the Tap: Antibiotic Resistance and Pathogenic Contamination of Kisumu City Water Supply and Wastewater Network

Tropical Medicine &International Health, EarlyView.
ABSTRACT Waterborne diseases and antimicrobial resistance (AMR) pose mounting public health threats across sub‐Saharan Africa, particularly in rapidly urbanising regions dependent on untreated or poorly treated surface waters. This study applied shotgun metagenomic sequencing to characterise microbial communities, virulence factors and antibiotic ...
Oleg N. Reva, Anthony Sifuna, Francis Orata, Caroline Omolo, Jacob Stanley Iramiot, Mark C. Enright, Awelani Mutshembele, Jian Zhou, William A. Shivoga   +8 more
wiley   +1 more source

In VitroActivity of Biapenem plus RPX7009, a Carbapenem Combined with a Serine β-Lactamase Inhibitor, against Anaerobic Bacteria [PDF]

, 2013
Ellie J. C. Goldstein, Diane M. Citron, Kerin L. Tyrrell, C. Vreni Merriam   +3 more
openalex   +1 more source

In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales

, 2023
Olga Lomovskaya, Mariana Castanheira, Jill Lindley, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski, Dongxu Sun, Maxim Totrov, Jeffery S. Loutit, Michael Dudley   +9 more
openalex   +1 more source

Farm‐Level Factors Associated With Multidrug‐Resistant Escherichia coli and Klebsiella spp. in Bulk Tank Milk in Tigray, Northern Ethiopia

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This cross‐sectional study identified farm‐level factors associated with multidrug‐resistant (MDR) Escherichia coli and Klebsiella spp. in bulk tank milk in Tigray, Northern Ethiopia, emphasizing the role of antimicrobial use practices and hygiene management in MDR occurrence within dairy production systems.
Goyitom Gebremedhn Gebru, Saravanan Muthupandian, Enquebaher Kassaye   +2 more
wiley   +1 more source