Results 31 to 40 of about 19,900 (217)

Further considerations to improve the druggability of biaryl hydroxy-triazole and fluorene-triazole hybrids [PDF]

Exploration of Drug Science
Buarque et al. (Explor Drug Sci. 2025;3:1008107. DOI: 10.37349/eds.2025.1008107) reported the synthesis of 13 biaryl hydroxy-1,2,3-triazoles and 11 fluorene-1,2,3-triazole hybrids via optimized Suzuki and telescopic one-pot reactions.
Zhiqi Liu, Meihong Zhang, Zhengwei Huang
doaj   +1 more source

A pyrene-functionalized triazole-linked hexahomotrioxacalix[3]arene as a fluorescent chemosensor for Zn²⁺ ions [PDF]

, 2016
A new pyrenyl appended hexahomotrioxacalix[3]arene L featuring 1,2,3-triazole linkers was synthesized as a fluorescent chemosensor for Zn²⁺ in mixed aqueous media. It exhibited high affinity toward Zn²⁺, and the monomer and excimer emission of the pyrene
Ikejiri, Yusuke, Jiang, Xue-Kai, Ni, Xin-Long, Redshaw, Carl, Wu, Chong, Yamato, Takehiko, Zeng, Xi, Zhao, Jiang-Lin   +7 more
core   +2 more sources

Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry

Molecules, 2021
Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound.
Lori Gonnet, Michel Baron, Michel Baltas
doaj   +1 more source

One pot ‘click’ reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition [PDF]

, 2010
Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.
Campbell-Verduyn, Lachlan S.,, Dierckx, Rudi A.,, Elsinga, Philip H.,, Feringa, Ben L.,, Janssen, Dick B.,, Postema, Christiaan P.,, Szymański, Wiktor,   +6 more
core   +3 more sources

Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety

Molecules, 2019
To discover novel potent cytotoxic diterpenoids, a series of hybrids of dehydroabietic acid containing 1,2,3-triazole moiety were designed and synthesized.
Fang-Yao Li, Lin Huang, Qian Li, Xiu Wang, Xian-Li Ma, Cai-Na Jiang, Xiao-Qun Zhou, Wen-Gui Duan, Fu-Hou Lei   +8 more
doaj   +1 more source

Radiosynthesis of 5-[¹⁸F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[¹⁸F]Fluorine Exchange Reaction

Molecules, 2021
In this report, a simple and efficient process to achieve fluorine-18-labeled 1,2,3-triazole is reported. The heteroaromatic radiofluorination was successfully achieved through an iodine–fluorine-18 exchange in an aqueous medium requiring only trace ...
Xiang Zhang, Falguni Basuli, Sameh Abdelwahed, Tadhg Begley, Rolf Swenson   +4 more
doaj   +1 more source

Design and Antiproliferative Evaluation of Novel Sulfanilamide Derivatives as Potential Tubulin Polymerization Inhibitors

Molecules, 2017
A series of sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, MCF-7 and PC-3).
Dong-Jun Fu, Ji-Feng Liu, Ruo-Han Zhao, Jia-Huan Li, Sai-Yang Zhang, Yan-Bing Zhang   +5 more
doaj   +1 more source

Triazole-Directed Pd-Catalyzed C(sp2)–H Oxygenation of Arenes and Alkenes [PDF]

, 2016
Selective Pd-catalyzed C(sp2)–H oxygenation of 4-substituted 1,2,3-triazoles is described. Unlike previous metal-catalyzed C–H functionalization events, which preferentially occur at the activated heterocyclic C–H bond, the regioselective oxygenation of ...
Aizpurua Iparraguirre, Jesús María, Correa Navarro, Arkaitz, Irastorza Epelde, Aitziber   +2 more
core   +2 more sources

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores [PDF]

Chemistry – An Asian Journal, 2011
AbstractThe copper(I)‐catalyzed 1,2,3‐triazole‐forming reaction between azides and terminal alkynes has become the gold standard of ‘click chemistry’ due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial ...
Sandip G, Agalave, Suleman R, Maujan, Vandana S, Pore   +2 more
openaire   +2 more sources

Design, synthesis, in silico and in vitro antimicrobial screenings of novel 1,2,4-triazoles carrying 1,2,3-triazole scaffold with lipophilic side chain tether

Chemistry Central Journal, 2017
Background 1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. Results This study describes a green, efficient and quick solvent free click synthesis of new 1,2,3-triazole-4,5-diesters carrying a lipophilic side
Mohamed Reda Aouad, Mariem Mohammed Mayaba, Arshi Naqvi, Sanaa K. Bardaweel, Fawzia Faleh Al-blewi, Mouslim Messali, Nadjet Rezki   +6 more
doaj   +1 more source