Results 41 to 50 of about 20,375 (237)

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells [PDF]

, 2010
The small molecule 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3- d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphological changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those ...
Barr, Bock, David J. Stephens, Derby, Doherty, Erickson, Falnes, Feng, Feng, Fiebiger, Frédéric Boal, Fuchs, Gewald, Girod, Guetzoyan, Guy J. Clarkson, Helms, Herold, Hey, Hill, J. Michael Lord, Jackson, Johannes, Johannes, Johannes, Klausner, Lieu, Linstedt, Lu, Lucie J. Guetzoyan, Lynne M. Roberts, Macia, McKenzie, Monier, Nambiar, Nieland, Pavelka, Pelish, Perez-Victoria, Peyroche, Pirali, Plourde, Ponnambalam, Renault, Robert A. Spooner, Rostovtsev, Saenz, Saenz, Sandvig, Shima, Shin, Shin, Spooner, Spooner, Stechmann, Tai, Tsai, Viaud, Volpicelli-Daley, Wells, White, Wilcke, Yarrow, Yoshino, Zeghouf, Zhang, Zhao, Zolov   +67 more
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1,2,3-Triazoles

, 2008
Rapid progress in the synthetic application of benzotriazole derivatives in the last 20 years has resulted in over 1000 scientific papers on the subject. This fact is reflected in Section 5.01.7, which involves almost a half of the volume of this chapter. The section is arranged according to hybridization of the C-α atom and atomic numbers of the atoms
Rachwal, S., Katritzky, A.R.
openaire   +1 more source

Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety

Molecules, 2019
To discover novel potent cytotoxic diterpenoids, a series of hybrids of dehydroabietic acid containing 1,2,3-triazole moiety were designed and synthesized.
Fang-Yao Li, Lin Huang, Qian Li, Xiu Wang, Xian-Li Ma, Cai-Na Jiang, Xiao-Qun Zhou, Wen-Gui Duan, Fu-Hou Lei   +8 more
doaj   +1 more source

Synthesis of 1,2,3-triazole functionalized hyperbranched poly(ethyleneimine) and its use as multifunctional anionic macroinitiator for diglycidyl ether of bisphenol A curing [PDF]

, 2016
Hyperbranched poly(ethyleneimine) (PEI) has been modified by the addition of propargyl acrylate following a Michael addition reaction. On this polymer (PEI-yne) a copper (I)-catalyzed azide alkyne cycloaddition (CuAAC) has been performed to obtain a ...
Acebo Gorostiza, Cristina, Appelhans, Dietmar, Lederer, Albena, Ramis Juan, Xavier, Serra Albet, Àngels   +4 more
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Design and Antiproliferative Evaluation of Novel Sulfanilamide Derivatives as Potential Tubulin Polymerization Inhibitors

Molecules, 2017
A series of sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, MCF-7 and PC-3).
Dong-Jun Fu, Ji-Feng Liu, Ruo-Han Zhao, Jia-Huan Li, Sai-Yang Zhang, Yan-Bing Zhang   +5 more
doaj   +1 more source

Triazole-Directed Pd-Catalyzed C(sp2)–H Oxygenation of Arenes and Alkenes [PDF]

, 2016
Selective Pd-catalyzed C(sp2)–H oxygenation of 4-substituted 1,2,3-triazoles is described. Unlike previous metal-catalyzed C–H functionalization events, which preferentially occur at the activated heterocyclic C–H bond, the regioselective oxygenation of ...
Aizpurua Iparraguirre, Jesús María, Correa Navarro, Arkaitz, Irastorza Epelde, Aitziber   +2 more
core   +2 more sources

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics [PDF]

Angewandte Chemie International Edition, 2016
AbstractThe macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme‐mediated methods remain of great interest in terms of synthetic utility.
Emilia Oueis, Marcel Jaspars, Nicholas J. Westwood, James H. Naismith   +3 more
openaire   +6 more sources

Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids

Molecules, 2018
A library of novel regioselective 1,4-di and 1,4,5-trisubstituted-1,2,3-triazole based benzothiazole-piperazine conjugates were designed and synthesized using the click synthesis approach in the presence and absence of the Cu(I) catalyst. Some of these 1,
Mohamed R. Aouad, Moataz A. Soliman, Muath O. Alharbi, Sanaa K. Bardaweel, Pramod K. Sahu, Adeeb A. Ali, Mouslim Messali, Nadjet Rezki, Yaseen A. Al-Soud   +8 more
doaj   +1 more source

4,5-Dicyano-1,2,3-Triazole—A Promising Precursor for a New Family of Energetic Compounds and Its Nitrogen-Rich Derivatives: Synthesis and Crystal Structures

Molecules, 2021
The nitrogen-rich compounds and intermediates with structure of monocyclic, bicyclic, and fused rings based on 1,2,3-triazole were synthesized and prepared by using a promising precursor named 4,5-dicyano-1,2,3-triazole, which was obtained by the ...
Wenli Cao, Jian Qin, Jianguo Zhang, Valery P. Sinditskii   +3 more
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Density Function Theory Study on the Energy and Circular Dichroism Spectrum for Methylene-Linked Triazole Diads Depending on the Substitution Position and Conformation

Molecules
Since the discovery of metal-catalyzed azide–alkyne cycloadditions, 1,2,3-triazoles have been widely used as linkers for various residues. 1,2,3-Triazole is an aromatic five-membered cyclic compound consisting of three nitrogen and two carbon atoms with ...
Masaki Nakahata, Akihito Hashidzume
doaj   +1 more source