Results 41 to 50 of about 50,236 (242)

Design, Synthesis and Bioevaluation of Highly Functionalized 1,2,3-Triazole-Guanidine Conjugates as Anti-Inflammatory and Antioxidant Agents

, 2022
In search of new biologically potent molecules a small focused library of new guanidine-1,2,3-triazole hybrid derivatives were synthesized via Organocatalytic enolate- mediated azide-carbonyl [3 + 2] cycloaddition yielding a highly functionalized ...
Mubarak H. Shaikh (9373121), Vijay M. Khedkar (554344), Ashish Asrondkar (13213621), Amit A. Pund (9366913), Rashiqua A. Siddiqui (13213618), Bapurao B. Shingate (8051171), Prathmesh P. Deshpande (13213624), Amol A. Nagargoje (9383810), Madiha A. Siddiqui (13213615)   +8 more
core   +1 more source

Density Function Theory Study on the Energy and Circular Dichroism Spectrum for Methylene-Linked Triazole Diads Depending on the Substitution Position and Conformation

Molecules
Since the discovery of metal-catalyzed azide–alkyne cycloadditions, 1,2,3-triazoles have been widely used as linkers for various residues. 1,2,3-Triazole is an aromatic five-membered cyclic compound consisting of three nitrogen and two carbon atoms with ...
Masaki Nakahata, Akihito Hashidzume
doaj   +1 more source

Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids

Molecules, 2018
A library of novel regioselective 1,4-di and 1,4,5-trisubstituted-1,2,3-triazole based benzothiazole-piperazine conjugates were designed and synthesized using the click synthesis approach in the presence and absence of the Cu(I) catalyst. Some of these 1,
Mohamed R. Aouad, Moataz A. Soliman, Muath O. Alharbi, Sanaa K. Bardaweel, Pramod K. Sahu, Adeeb A. Ali, Mouslim Messali, Nadjet Rezki, Yaseen A. Al-Soud   +8 more
doaj   +1 more source

Metal Free Domino β‑Azidation/[3 + 2] Cycloaddition Reaction for the Synthesis of 1,2,3-Triazole-Fused Dihydrobenzoxazinones

, 2019
A metal free DBU catalyzed synthesis of 1,2,3-triazole-fused dihydrobenzoxazinone derivatives by tandem β-azidation/[3 + 2] cycloaddition reaction has been developed under mild conditions.
Kiranmai Nayani (7148414), Sangeetha Donikela (1589692), Sangeetha Donikela, Prathama S. Mainkar, Srivari Chandrasekhar, Prathama S. Mainkar (447913), Srivari Chandrasekhar (626160), Kiranmai Nayani   +7 more
core   +2 more sources

1,2,3-Triazole: an important scaffold in drug design and development

Heterocyclic Communications
1,2,3-triazole represents a class of nitrogen-containing heterocyclics with a wide range of biological activity. The medicinal applications of 1,2,3-triazole derivatives, including antioxidant, antimicrobial, antiviral, anti-inflammatory, antitumor, and ...
Alghamdi Danyah Y., Zailaee Rasha A., Al-Amshany Zahra M., El-Shishtawy Reda M.   +3 more
doaj   +1 more source

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety

Molecules, 2017
In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole ...
Nadia A. Abdelriheem, Ali M. M. Mohamed, Abdou O. Abdelhamid   +2 more
doaj   +1 more source

4,5-Dicyano-1,2,3-Triazole—A Promising Precursor for a New Family of Energetic Compounds and Its Nitrogen-Rich Derivatives: Synthesis and Crystal Structures

Molecules, 2021
The nitrogen-rich compounds and intermediates with structure of monocyclic, bicyclic, and fused rings based on 1,2,3-triazole were synthesized and prepared by using a promising precursor named 4,5-dicyano-1,2,3-triazole, which was obtained by the ...
Wenli Cao, Jian Qin, Jianguo Zhang, Valery P. Sinditskii   +3 more
doaj   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

1,2,3-Triazole-Based Hybrids as EGFR Inhibitors: An overview [PDF]

Records of Pharmaceutical & Biomedical Sciences
Cancer continues to be a leading cause of mortality worldwide, presenting a major global public health concern. Despite advances in treatment, the discovery and development of effective anticancer drugs remain significant challenges for medicinal ...
Asmaa Yassen, Nareman A. Nawareg, Ebtehal M. Husseiny, Magda A. A. El-Sayed, Hosam Elshihawy   +4 more
doaj   +1 more source

Synthesis and Structure Determination of 1-(4-Methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide

Molbank, 2022
A reaction of equimolar equivalents of 1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (1) and indoline-2,3-dione (2) in boiling ethanol for 4 h under acidic conditions gave 1-(4-methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2 ...
Benson M. Kariuki, Bakr F. Abdel-Wahab, Abdelbasset A. Farahat, Gamal A. El-Hiti   +3 more
doaj   +1 more source