Results 21 to 30 of about 61,653 (192)

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Click Chemistry Approach to Isoindole-1,3-dione Tethered 1,2,3-Triazole Derivatives

SynOpen, 2019
A convenient and efficient approach for the synthesis of novel 1,2,3-triazole tethered isoindol-1,3-dione conjugates by a nucleophilic substitution reaction of phthalic anhydride with 1,2,3-triazole containing carbohydrazide is described. The latter were
Rajneesh Kaur, Raman Singh, Antresh Kumar, Kuldeep Singh   +3 more
doaj   +1 more source

Atroposelective Pd(0)‐Catalyzed Direct Intermolecular C─H Arylation of Thiazole N‐Oxides Provides Access to Heterobiaryls

Angewandte Chemie, EarlyView.
An enantioselective Pd(0)‐catalysed arylation at the C4‐position of thiazole N‐oxides directly forges the atropochiral heterobiaryl axis. A tailored point‐ and axially chiral monodentate phosphine ensures high reactivities along with a tight stereocontrol.
Vitalii Smal, Nicolai Cramer
wiley   +2 more sources

Further considerations to improve the druggability of biaryl hydroxy-triazole and fluorene-triazole hybrids [PDF]

Exploration of Drug Science
Buarque et al. (Explor Drug Sci. 2025;3:1008107. DOI: 10.37349/eds.2025.1008107) reported the synthesis of 13 biaryl hydroxy-1,2,3-triazoles and 11 fluorene-1,2,3-triazole hybrids via optimized Suzuki and telescopic one-pot reactions.
Zhiqi Liu, Meihong Zhang, Zhengwei Huang
doaj   +1 more source

Identification of 8-Azaguanine Biosynthesis–Related Genes Provides Insight Into the Enzymatic and Non-enzymatic Biosynthetic Pathway for 1,2,3-Triazole

Frontiers in Bioengineering and Biotechnology, 2020
8-Azaguanine (1) is a special 1,2,3-triazole containing natural product that possesses potent antibacterial and antitumor activities. In the present study, the entire 8-azaguanine biosynthetic gene cluster was located from Streptomyces CGMCC4.1633 ...
Feifei Hou, Feifei Hou, Yupeng Wan, Yupeng Wan, Qi Gan, Mo Xian, Wei Huang   +6 more
doaj   +1 more source

Three-component synthesis of 1,2,3-triazoles in the presence of PVC-supported triazole-copper complex by click reaction [PDF]

شیمی کاربردی روز, 2020
In this research work novel PVC-supported triazole-copper(I) iodide catalyst (PVC–Triazole–CuI) was prepared and used the for synthesis of 1,2,3-triazoles.
Ali Keivanloo, Mostafa Gholizadeh, Elnaz Rezaii   +2 more
doaj   +1 more source

Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids

Molecules, 2023
Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives.
Alexandra Németh-Rieder, Péter Keglevich, Attila Hunyadi, Ahmed Dhahir Latif, István Zupkó, László Hazai   +5 more
doaj   +1 more source

Synthesis of 1H-1,2,3-triazole-4-carbonitriles as building blocks for promising 2-(triazol-4-yl)-thieno[2,3-d]pyrimidine drug candidates

, 2021
A new synthetic route leading to functionalized 1H-1,2,3-triazole-4-carbonitriles has been developed. A set of 1-aryl-5-methyl-1H-1,2,3-triazole-4-carbonitriles was obtained in high yields from readily available starting 1H-1,2,3-triazole-4-carboxylic ...
Taras V. Sekh (11341646), Nazariy T. Pokhodylo (526405), Mykola D. Obushak (11341652), Olga Y. Shyyka (11341649)   +3 more
core   +1 more source

Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety

Molecules, 2019
To discover novel potent cytotoxic diterpenoids, a series of hybrids of dehydroabietic acid containing 1,2,3-triazole moiety were designed and synthesized.
Fang-Yao Li, Lin Huang, Qian Li, Xiu Wang, Xian-Li Ma, Cai-Na Jiang, Xiao-Qun Zhou, Wen-Gui Duan, Fu-Hou Lei   +8 more
doaj   +1 more source

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Frontiers in Pharmacology, 2021
Lung cancer is the most common malignancy and leads to around one-quarter of all cancer deaths. Great advances have been achieved in the treatment of lung cancer with novel anticancer agents and improved technology. However, morbidity and mortality rates
Ting Liang, Xiangyang Sun, Wenhong Li, Guihua Hou, Feng Gao   +4 more
doaj   +1 more source