Results 21 to 30 of about 8,430 (199)

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Frontiers in Pharmacology, 2021
Lung cancer is the most common malignancy and leads to around one-quarter of all cancer deaths. Great advances have been achieved in the treatment of lung cancer with novel anticancer agents and improved technology. However, morbidity and mortality rates
Ting Liang, Xiangyang Sun, Wenhong Li, Guihua Hou, Feng Gao   +4 more
doaj   +1 more source

Further considerations to improve the druggability of biaryl hydroxy-triazole and fluorene-triazole hybrids [PDF]

Exploration of Drug Science
Buarque et al. (Explor Drug Sci. 2025;3:1008107. DOI: 10.37349/eds.2025.1008107) reported the synthesis of 13 biaryl hydroxy-1,2,3-triazoles and 11 fluorene-1,2,3-triazole hybrids via optimized Suzuki and telescopic one-pot reactions.
Zhiqi Liu, Meihong Zhang, Zhengwei Huang
doaj   +1 more source

Identification of 8-Azaguanine Biosynthesis–Related Genes Provides Insight Into the Enzymatic and Non-enzymatic Biosynthetic Pathway for 1,2,3-Triazole

Frontiers in Bioengineering and Biotechnology, 2020
8-Azaguanine (1) is a special 1,2,3-triazole containing natural product that possesses potent antibacterial and antitumor activities. In the present study, the entire 8-azaguanine biosynthetic gene cluster was located from Streptomyces CGMCC4.1633 ...
Feifei Hou, Feifei Hou, Yupeng Wan, Yupeng Wan, Qi Gan, Mo Xian, Wei Huang   +6 more
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Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids

Molecules, 2023
Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives.
Alexandra Németh-Rieder, Péter Keglevich, Attila Hunyadi, Ahmed Dhahir Latif, István Zupkó, László Hazai   +5 more
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1,2,3-Triazoles

, 2008
Rapid progress in the synthetic application of benzotriazole derivatives in the last 20 years has resulted in over 1000 scientific papers on the subject. This fact is reflected in Section 5.01.7, which involves almost a half of the volume of this chapter. The section is arranged according to hybridization of the C-α atom and atomic numbers of the atoms
Rachwal, S., Katritzky, A.R.
openaire   +1 more source

Transformations of 1-(Oxiranylmethyl)-1,2,3-triazoles into 2-(Oxiranyl­methyl)-1,2,3-triazoles and Alkanenitriles [PDF]

Synlett, 2012
New reactions for the transformation of 1-(oxiranylmethyl)-1,2,3-triazoles into 2-(oxiranylmethyl)-1,2,3-triazoles or alkanenitriles were established. Successive treatment of the substrate with triflic acid and t-BuOH afforded 4,6-dihydro-5-hydroxy-1,3a,6a-triazapentalene derivative.
Osawa, Ayumi, Mera, Akane, Namba, Kosuke, Tanino, Keiji   +3 more
openaire   +2 more sources

Biochemical and in silico inhibition of bovine and human carbonic anhydrase-II by 1H-1,2,3-triazole analogs

Frontiers in Chemistry, 2022
A series of 1H-1,2,3-triazole analogs (7a–7d and 9a–9s) were synthesized via “click” chemistry and evaluated for in vitro carbonic anhydrase-II (bovine and human) inhibitory activity. The synthesis of intermediates, 7a and 7c, was achieved by using (S)-(-
Majid Khan, Majid Khan, Satya Kumar Avula, Sobia Ahsan Halim, Muhammad Waqas, Mufarreh Asmari, Ajmal Khan, Ahmed Al-Harrasi   +7 more
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Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety

Molecules, 2019
To discover novel potent cytotoxic diterpenoids, a series of hybrids of dehydroabietic acid containing 1,2,3-triazole moiety were designed and synthesized.
Fang-Yao Li, Lin Huang, Qian Li, Xiu Wang, Xian-Li Ma, Cai-Na Jiang, Xiao-Qun Zhou, Wen-Gui Duan, Fu-Hou Lei   +8 more
doaj   +1 more source

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores [PDF]

Chemistry – An Asian Journal, 2011
AbstractThe copper(I)‐catalyzed 1,2,3‐triazole‐forming reaction between azides and terminal alkynes has become the gold standard of ‘click chemistry’ due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial ...
Sandip G, Agalave, Suleman R, Maujan, Vandana S, Pore   +2 more
openaire   +2 more sources

Design and Antiproliferative Evaluation of Novel Sulfanilamide Derivatives as Potential Tubulin Polymerization Inhibitors

Molecules, 2017
A series of sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, MCF-7 and PC-3).
Dong-Jun Fu, Ji-Feng Liu, Ruo-Han Zhao, Jia-Huan Li, Sai-Yang Zhang, Yan-Bing Zhang   +5 more
doaj   +1 more source