Results 31 to 40 of about 61,653 (192)

Density Function Theory Study on the Energy and Circular Dichroism Spectrum for Methylene-Linked Triazole Diads Depending on the Substitution Position and Conformation

Molecules
Since the discovery of metal-catalyzed azide–alkyne cycloadditions, 1,2,3-triazoles have been widely used as linkers for various residues. 1,2,3-Triazole is an aromatic five-membered cyclic compound consisting of three nitrogen and two carbon atoms with ...
Masaki Nakahata, Akihito Hashidzume
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Design, synthesis, in silico and in vitro antimicrobial screenings of novel 1,2,4-triazoles carrying 1,2,3-triazole scaffold with lipophilic side chain tether

Chemistry Central Journal, 2017
Background 1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. Results This study describes a green, efficient and quick solvent free click synthesis of new 1,2,3-triazole-4,5-diesters carrying a lipophilic side
Mohamed Reda Aouad, Mariem Mohammed Mayaba, Arshi Naqvi, Sanaa K. Bardaweel, Fawzia Faleh Al-blewi, Mouslim Messali, Nadjet Rezki   +6 more
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Biochemical and in silico inhibition of bovine and human carbonic anhydrase-II by 1H-1,2,3-triazole analogs

Frontiers in Chemistry, 2022
A series of 1H-1,2,3-triazole analogs (7a–7d and 9a–9s) were synthesized via “click” chemistry and evaluated for in vitro carbonic anhydrase-II (bovine and human) inhibitory activity. The synthesis of intermediates, 7a and 7c, was achieved by using (S)-(-
Majid Khan, Majid Khan, Satya Kumar Avula, Sobia Ahsan Halim, Muhammad Waqas, Mufarreh Asmari, Ajmal Khan, Ahmed Al-Harrasi   +7 more
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Advances in the synthesis of 1,2,3-triazole based energetic compounds: A review

Defence Technology
1,2,3-Triazole-based energetic compounds have attracted widespread attention in the field of energetic materials due to their high heats of formation, high density, good stability, and environmental friendliness.
Bibo Li, Zhongchao Li, Xinghui Liu, Jianlong Wang, Yunlu Li, Shangbiao Feng, Ping Yin   +6 more
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Design and Antiproliferative Evaluation of Novel Sulfanilamide Derivatives as Potential Tubulin Polymerization Inhibitors

Molecules, 2017
A series of sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, MCF-7 and PC-3).
Dong-Jun Fu, Ji-Feng Liu, Ruo-Han Zhao, Jia-Huan Li, Sai-Yang Zhang, Yan-Bing Zhang   +5 more
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Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry

Molecules, 2021
Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound.
Lori Gonnet, Michel Baron, Michel Baltas
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Design, Synthesis and Bioevaluation of Highly Functionalized 1,2,3-Triazole-Guanidine Conjugates as Anti-Inflammatory and Antioxidant Agents

, 2022
In search of new biologically potent molecules a small focused library of new guanidine-1,2,3-triazole hybrid derivatives were synthesized via Organocatalytic enolate- mediated azide-carbonyl [3 + 2] cycloaddition yielding a highly functionalized ...
Mubarak H. Shaikh (9373121), Vijay M. Khedkar (554344), Ashish Asrondkar (13213621), Amit A. Pund (9366913), Rashiqua A. Siddiqui (13213618), Bapurao B. Shingate (8051171), Prathmesh P. Deshpande (13213624), Amol A. Nagargoje (9383810), Madiha A. Siddiqui (13213615)   +8 more
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Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids

Molecules, 2018
A library of novel regioselective 1,4-di and 1,4,5-trisubstituted-1,2,3-triazole based benzothiazole-piperazine conjugates were designed and synthesized using the click synthesis approach in the presence and absence of the Cu(I) catalyst. Some of these 1,
Mohamed R. Aouad, Moataz A. Soliman, Muath O. Alharbi, Sanaa K. Bardaweel, Pramod K. Sahu, Adeeb A. Ali, Mouslim Messali, Nadjet Rezki, Yaseen A. Al-Soud   +8 more
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1,2,3-Triazole: an important scaffold in drug design and development

Heterocyclic Communications
1,2,3-triazole represents a class of nitrogen-containing heterocyclics with a wide range of biological activity. The medicinal applications of 1,2,3-triazole derivatives, including antioxidant, antimicrobial, antiviral, anti-inflammatory, antitumor, and ...
Alghamdi Danyah Y., Zailaee Rasha A., Al-Amshany Zahra M., El-Shishtawy Reda M.   +3 more
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Validation of Semiempirical Calculation Methods for the Development of 1,2,3-Triazole-based Compounds

Jurnal Kimia Sains dan Aplikasi
Compounds based on 1,2,3-triazole have been widely utilized as anticancer agents. There are hydrogen bonds in compounds that can interact with a target biomolecule to form new compounds or derivative compounds that have useful biological activities.
Ponco Iswanto, Yesicha Megawarni Lumban Raja, Zhafran Aliffathin, Ely Setiawan, Heny Ekowati   +4 more
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