Results 51 to 60 of about 8,430 (199)

Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle

Chemistry – A European Journal, EarlyView.
Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou, Jinbiao Jiao, Mathieu Lordez, Jean‐Yves Salpin, Juan Xie   +4 more
wiley   +1 more source

Electrochemiluminescence of Heteroleptic Iridium(III) Complexes Featuring Substituted 2,4‐diphenylpyridinato Ligands

Chemistry – A European Journal, EarlyView.
Five heteroleptic iridium(III) complexes bearing cyclometalated 2,4‐diphenylpyridinato ligands were synthesized and their electrochemiluminescence (ECL) investigated. Two different coreactants were evaluated: tri‐n‐propylamine and benzoyl peroxide under anodic and cathodic potentials, respectively.
Ovini Jayawardana, El M. S. Martin, Oliver G. Stansfield, Egan H. Doeven, Carol Hua, Timothy U. Connell, Paul S. Francis   +6 more
wiley   +1 more source

Derivados 1,2,3-triazol

C&T, 2020
A administração de antimicrobianos nos casos de doenças infecciosas é inevitável, porém seu uso excessivo e indiscriminado vem influenciando na resistência bacteriana. Este cenário de saúde constitui uma extensa ameaça à população enferma e necessitada de tratamento terapêutico, o que torna necessário o empenho da comunidade científica na pesquisa e ...
Guilheane Gonçalves Barbosa, Alcino Palermo de Aguiar   +1 more
openaire   +1 more source

Molecular Modification Strategies for CO2 Electroreduction to C2+ Products: Classifications, Mechanisms, Advances, and Perspectives

EcoEnergy, EarlyView.
This review comprehensively outlines molecular modification strategies for steering CO2 electroreduction toward C2+ products, including the classification of diverse molecular structures, elucidation of their roles in microenvironment regulation, dissection of C–C coupling pathway engineering, and forward‐looking perspectives on machine learning and ...
Lingling Peng, Hanwen Liu, Tianyou Peng
wiley   +1 more source

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, EarlyView.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source

Synthesis and biological evaluation of norfloxacin – 1,2,3-triazole hybrids as antitumor, antibacterial, and antioxidant agents

Results in Chemistry
Six norfloxacin-1,2,3-triazole hybrids(7a-e) were synthesized via click reaction. Norfloxacin-1,2,3-triazole hybrids were screened for anti-cancer activity against different cancer cell lines DLD1, MCF-7, A549 and HDF.
Samir Al-Taweel, Yousef Al-Saraireh, Salah Al-Trawneh, Solhe Alshahateet, Rakan Al- Tarawneh, Wael Zereini, Omar Al-Qaralleh, Ahmed Al-sarayreh, Mohammad Salem Hareedy, Y.M. Abuhalaweh, Amer Hussien Tarawneh   +10 more
doaj   +1 more source

Chemoselective Aldehyde and Imine Reduction by a Macrocyclic Triazole–Borane Complex Triggered by a Non‐innocent Proton–Hydride Interaction

European Journal of Organic Chemistry, EarlyView.
This work describes the study on a new recyclable reagent, based on a macrocyclic triazole–borane complex. It showed high chemoselectivity for aldehyde reduction and reductive amination over ketones. This selectivity is driven by a noncovalent hydride–proton interaction that stabilizes the transition state for aldehydes but is sterically inhibited in ...
Luca Di Marino, Artur Brotons Rufes, Rosaria Schettini, Giorgio Della Sala, Francesco De Riccardis, Chiara Costabile, Irene Izzo   +6 more
wiley   +1 more source

Strategic Fusion: 1,2,3-Triazole Hybrids as Next-Generation Dual/Multi-Targeted Anticancer Agents – A 2025 Perspective [PDF]

Records of Pharmaceutical & Biomedical Sciences
The strategic hybridization of the 1,2,3-triazole scaffold with diverse bioactive pharmacophores has emerged as a pivotal strategy to overcome multidrug resistance (MDR) in cancer.
Heba Ashour, Asmaa Yassen, Khaled Selim, Magda A. A. El-Sayed, Hosam Elshihawy   +4 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Gold(I)‐Catalyzed Annulation of Pyridines Containing Alkyne: Synthesis of N‐Alkenyl Pyridonyl Azides via Rearrangement

Journal of Heterocyclic Chemistry, EarlyView.
One‐pot gold(I)‐catalysts synthesis was developed in order to prepare N‐alkenyl 2‐pyridonyl azides. This method provides a series of N‐alkenyl 2‐pyridonyl azides in moderate to excellent yields (up to 94%). ABSTRACT A novel strategy, involving the preparation of gold‐catalyzed cyclization salts and the rearrangement of these salts in the presence of ...
Ali Osman Karatavuk
wiley   +1 more source