Results 61 to 70 of about 20,375 (237)

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Synthesis of Ribosylated 1,2,3‐Triazole Derivatives.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Zhong‐Xu Ren, Xiao‐Min Chen, Zhan‐Jiang Li, Zhi‐Tang Huang   +3 more
openaire   +1 more source

SÍNTESE E AVALIAÇÃO DA ATIVIDADE CITOTÓXICA DE DERIVADOS DO EUGENOL CONTENDO NÚCLEOS 1,2,3-TRIAZÓLICOS

Química Nova
Eugenol is an aromatic compound found in several plant species. It presents important biological activities including cytotoxicity. In this paper, it is described the synthesis and the evaluation of the cytotoxic activity of eugenol derivatives bearing 1,
Poliana Aparecida Rodrigues Gazolla, Róbson Ricardo Teixeira, Adalberto Manoel da Silva, Boniek Gontijo Vaz, Géssica Adriana Vasconcelos, Raoni Pais Siqueira, Victor Hugo Sousa Gonçalves, Higor Sette Pereira, Gustavo Costa Bressan   +8 more
doaj   +1 more source

Ruthenium-catalyzed azide alkyne cycloaddition reaction: scope, mechanism and applications [PDF]

, 2016
The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer.
Akimova G., Akimova G., Akimova G., Anna Said Stålsmeden, Bader R. F. W., Chandrasekaran S., Das R., Fan W.-Q., Fokin V. V., Gruchlik A., Huisgen R., Johan R. Johansson, Keicher T., Levin J. I., Murahashi S.-I., Neumajer G., Nina Kann, Palaniraja J., Parsons J. G., Schilling C., Tamás Beke-Somfai, Trabocchi A., Yubo J., Zhou Y. B.   +23 more
core   +2 more sources

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives [PDF]

, 2015
A library of 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-1,2,3-triazoles have been investigated for their antibacterial, antifungal and cytotoxic activities.
Barros, M. Teresa, Calhelha, Ricardo C., Correia-da-Silva, Paula, Ferreira, Isabel C.F.R., Petrova, Krasimira T., Potewar, Taterao M., Soković, Marina, Ćirić, Ana   +7 more
core   +1 more source

Coordinatively unsaturated ruthenium complexes as efficient alkyne-azide cycloaddition catalysts [PDF]

, 2012
The performance of 16-electron ruthenium complexes with the general formula Cp*Ru(L)X (in which L = phosphine or N-heterocyclic carbene ligand; X = Cl or OCH2CF3) was explored in azide−alkyne cycloaddition reactions that afford the 1,2,3- triazole ...
Broggi, Julie, Cavallo, Luigi, Fortman, George C., Lamberti, Marina, Nolan, Steven P., Poater, Albert, Slawin, Alexandra M. Z.   +6 more
core   +2 more sources

Synthesis of novel Glycoconjugates derived from Alkynyl heterocycles through a click approach [PDF]

, 2013
Accepted author version posted online: 05 Jun 2012The synthesis of a series of novel 1,4-disubstituted 1,2,3-triazole compounds bearing a D-glucose derivative and an heteroaromatic system is described.
Ana M. F. Oliveira-Campos, Ana P. Esteves, Aragão-Leoneti V., Goutarel R., João C. O. Gonçalves, Lígia M. Rodrigues, Marília Silva   +6 more
core   +1 more source

Synthesis and Characterization of 1,2,3- Triazole Derivatives from D-Mannitol

Tikrit Journal of Pure Science, 2023
This research included the use of azido D-Mannitol (3) to synthesize 1,2,3 triazole derivatives. Azido D – Mannitol  (3) itself used as an intermediate which was prepared from reaction of  1, 2:5, 6-Di-o-isopropylidene-3,4-di-p-tosyl-D-Mannitol (2) with
Ihmood Kh. Juber
doaj   +1 more source

Click chemistry: In vitro evaluation of glycosyl hybrid phosphorylated/thiophosphorylated 1,2,3-triazole derivatives as irreversible acetyl cholinesterase (AChE) inhibitors

Results in Chemistry, 2021
A novel series of phosphorylated/ thiophosphorylated glucosyl-1,2,3-triazole derivatives have been synthesized in three step process. The synthetic approach was progressed from the reaction of propargyl alcohol with dialkoxychlorophosphate/thiophosphate ...
B. Anjaneyulu, G.B. Dharma Rao, Tanima Bajaj   +2 more
doaj   +1 more source