Results 61 to 70 of about 61,653 (192)

Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry

Bulletin of the Korean Chemical Society, EarlyView.
Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah, Amirreza Mottafegh, Su‐Hyun Yoo, Jongwoon Kim, Minseon Byeon, Juhwan Noh, Yea‐Lee Lee, Jin Suk Myung, Gwang‐Noh Ahn   +8 more
wiley   +1 more source

The synthesis of [1,2,3]-triazole-based bent core liquid crystals via microwave-mediated ‘Click Reaction’ and their mesomorphic behaviour

, 2019
A series of [1,2,3]-triazole-based liquid crystal compounds were synthesised via a fast and efficient microwave-mediated ‘Click Reaction’ and their phase behaviour is presented.
Samuel Sprunt (2529220), Kunlun Wang (2794564), Robert J. Twieg (567348)   +2 more
core   +1 more source

Synthesis and biological evaluation of norfloxacin – 1,2,3-triazole hybrids as antitumor, antibacterial, and antioxidant agents

Results in Chemistry
Six norfloxacin-1,2,3-triazole hybrids(7a-e) were synthesized via click reaction. Norfloxacin-1,2,3-triazole hybrids were screened for anti-cancer activity against different cancer cell lines DLD1, MCF-7, A549 and HDF.
Samir Al-Taweel, Yousef Al-Saraireh, Salah Al-Trawneh, Solhe Alshahateet, Rakan Al- Tarawneh, Wael Zereini, Omar Al-Qaralleh, Ahmed Al-sarayreh, Mohammad Salem Hareedy, Y.M. Abuhalaweh, Amer Hussien Tarawneh   +10 more
doaj   +1 more source

Mild C─F Activation of Azido(per)Fluoroalkanes

Chemistry – A European Journal, EarlyView.
Mild and selective activation of C(sp3)–F bonds in azido(per)fluoroalkanes using thiolates was developed, leading to novel functionalized azides. The reaction is initiated by nucleophilic attack of the sulfur atom to the terminal nitrogen of the azido group, followed by fluoride ion elimination.
Olena Shaitanova, María Martínez Mallo, Sergii Suikov, Blanka Klepetářová, Josef Filgas, Petr Slavíček, Lucie Bednárová, Petr Beier   +7 more
wiley   +1 more source

Electrochemiluminescence of Heteroleptic Iridium(III) Complexes Featuring Substituted 2,4‐diphenylpyridinato Ligands

Chemistry – A European Journal, EarlyView.
Five heteroleptic iridium(III) complexes bearing cyclometalated 2,4‐diphenylpyridinato ligands were synthesized and their electrochemiluminescence (ECL) investigated. Two different coreactants were evaluated: tri‐n‐propylamine and benzoyl peroxide under anodic and cathodic potentials, respectively.
Ovini Jayawardana, El M. S. Martin, Oliver G. Stansfield, Egan H. Doeven, Carol Hua, Timothy U. Connell, Paul S. Francis   +6 more
wiley   +1 more source

Strategic Fusion: 1,2,3-Triazole Hybrids as Next-Generation Dual/Multi-Targeted Anticancer Agents – A 2025 Perspective [PDF]

Records of Pharmaceutical & Biomedical Sciences
The strategic hybridization of the 1,2,3-triazole scaffold with diverse bioactive pharmacophores has emerged as a pivotal strategy to overcome multidrug resistance (MDR) in cancer.
Heba Ashour, Asmaa Yassen, Khaled Selim, Magda A. A. El-Sayed, Hosam Elshihawy   +4 more
doaj   +1 more source

Synthesis and Characterization of Hemiindigo‐Based Glycoside and Glycomacrocycle

Chemistry – A European Journal, EarlyView.
Glycosyl hemiindigos: we have synthesized hemiindigo‐functionalized glycoside and glycomacrocycle which are photoswitchable under visible light irradiation with high photoconversion yield and fluorescence emission property in acetonitrile. The conformational constrained glycomacrocycle displayed more efficient photoisomerization.
Guilhem Fontaine, Rémi Métivier, Guillaume Laurent, Régis Guillot, Juan Xie   +4 more
wiley   +1 more source

Molecular Modification Strategies for CO2 Electroreduction to C2+ Products: Classifications, Mechanisms, Advances, and Perspectives

EcoEnergy, EarlyView.
This review comprehensively outlines molecular modification strategies for steering CO2 electroreduction toward C2+ products, including the classification of diverse molecular structures, elucidation of their roles in microenvironment regulation, dissection of C–C coupling pathway engineering, and forward‐looking perspectives on machine learning and ...
Lingling Peng, Hanwen Liu, Tianyou Peng
wiley   +1 more source

Introducing Axial Chirality into Mesoionic 4,4′-Bis(1,2,3-triazole) Dicarbenes [PDF]

, 2012
Mesoionic 4,4′-bis(1,2,3-triazole-5,5′-diylidene) Rh(I) complexes having a C2 chiral 4,4′-axis were accessed from 3-alkyltriazolium salts in virtually complete de.
Monasterio, Zaira, Mendicute, Claudio, Azcune, Itxaso, García-Lecina, Eva, Monasterio, Z., Altube, Ainhoa, Aizpurua, J.M., Sagartzazu-Aizpurua, Maialen, Fratila, Raluca M., Azcune, I., Mendicute, C., Garcia-Lecina, E., Altube, A., Miranda, J.I., Fratila, R.M., Sagartzazu-Aizpurua, M., Aizpurua, Jesús M., Miranda, José Ignacio   +17 more
core   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source