Results 81 to 90 of about 61,653 (192)

New 1,2,3-Triazole-genipin Analogues and Their Anti-Alzheimer’s Activity

A novel series of 1,2,3-triazole-genipin analogues were designed, synthesized, and evaluated for neuroprotective activity, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) inhibitory activity.
Jiraporn Tocharus (4672513), Apichart Suksamrarn (482768), Suwichada Jaipea (13008125), Patamawadee Silalai (13008122), Rungnapha Saeeng (2686342), Anan Athipornchai (6160775)   +5 more
core   +1 more source

Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.

PLoS ONE, 2013
Triazoles are known for their non-toxicity, higher stability and therapeutic activity. Few nucleoside (L1, L2 and L3) and non-nucleoside 1,2,3-triazoles (L4-L14) were synthesised using click chemistry and they were screened for tumor cell cytotoxicity ...
Jerald Mahesh Kumar, Mohammed M Idris, Gunda Srinivas, Pallerla Vinay Kumar, Vuppalapaty Meghah, Mitta Kavitha, Chada Raji Reddy, Prathama S Mainkar, Biswajit Pal, Srivari Chandrasekar, Narayana Nagesh   +10 more
doaj   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

DataSheet6_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.ZIP

, 2022
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081), Jie Zhao (49409), Ge Sun (332789), Jianxue Yang (11590054), Shuxiang Xu (11676219), Miaomiao Yuan (2005606), Wenjing Deng (7538348), Longfei Mao (9683276), Kaitai Yao (87945)   +8 more
core   +1 more source

Recent Development in the Synthesis of 1,2,3-Triazole Derivatives Using Nanocatalysts

Bulletin of Chemical Reaction Engineering & Catalysis
1,2,3-Triazole is an aromatic, five-membered, π-excessive heterocycle comprised of three regular nitrogen atoms. 1,2,3-Triazoles possess a broad spectrum of bioactivities such as anticancer, antimicrobial, anti-inflammatory, antidiabetic, antiviral, and ...
Nguyen Van Quoc, Nguyen Thi Phuong Thao, Dau Xuan Duc   +2 more
doaj   +1 more source

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

The Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá, Patrick C. Nobre, Isabelly O. Ferreira, Juliano B. Azeredo, Vanessa Nascimento   +4 more
wiley   +1 more source

DataSheet3_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.PDF

, 2022
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081), Jie Zhao (49409), Ge Sun (332789), Jianxue Yang (11590054), Shuxiang Xu (11676219), Miaomiao Yuan (2005606), Wenjing Deng (7538348), Longfei Mao (9683276), Kaitai Yao (87945)   +8 more
core   +1 more source

Beyond monofunctionality: structural perspectives on phenol oxidase side activity in a catalase

Acta Crystallographica Section D, EarlyView.
Structural and biochemical characterization of the extracellular fungal catalase ClCPO uncovers an unexpected phenol oxidase promiscuity. Crystal structures, substrate docking and electron‐transfer pathway analysis identify ligand‐binding regions and support a working mechanistic model for catalase‐associated phenol oxidase activity.Catalases are ...
Christina Ferousi, Christos Kosinas, Odyssefs Ioannis Pantelakis, Efstratios Nikolaivits, Evangelos Topakas, Maria Dimarogona   +5 more
wiley   +1 more source

Table6_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.XLS

, 2022
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081), Jie Zhao (49409), Ge Sun (332789), Jianxue Yang (11590054), Shuxiang Xu (11676219), Miaomiao Yuan (2005606), Wenjing Deng (7538348), Longfei Mao (9683276), Kaitai Yao (87945)   +8 more
core   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source