DataSheet5_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.ZIP [PDF]
, 2022 Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081) +8 more
core +1 more source
A Low‐Symmetry FeII Tetrahedron From a Flexible Tritopic Ligand
Chemistry – A European Journal, EarlyView.A highly symmetric and flexible tris‐bidentate tritopic ligand forms an S4 meso homoleptic face‐capped FeII tetrahedron near‐quantitatively in acetonitrile. The addition of nitromethane solvent causes partial isomerization of this meso cage to the racemic homochiral tetrahedron, with the complexity of the system being moderated through solvophobic ...
Rosemary J. Goodwin +5 more
wiley +1 more source
C&T, 2020 A administração de antimicrobianos nos casos de doenças infecciosas é inevitável, porém seu uso excessivo e indiscriminado vem influenciando na resistência bacteriana. Este cenário de saúde constitui uma extensa ameaça à população enferma e necessitada de tratamento terapêutico, o que torna necessário o empenho da comunidade científica na pesquisa e ...
Guilheane Gonçalves Barbosa +1 more
openaire +1 more source
Table1_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.XLSX [PDF]
, 2022 Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081) +8 more
core +1 more source
Chemistry – A European Journal, EarlyView.Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato +3 more
wiley +1 more source
Results in ChemistrySix norfloxacin-1,2,3-triazole hybrids(7a-e) were synthesized via click reaction. Norfloxacin-1,2,3-triazole hybrids were screened for anti-cancer activity against different cancer cell lines DLD1, MCF-7, A549 and HDF.
Samir Al-Taweel +10 more
doaj +1 more source
One-pot synthesis of novel 1,2,3-triazole-pyrimido[4,5-c]isoquinoline hybrids and evaluation of their antioxidant activity [PDF]
, 2018 A series of novel pyrimido[4,5-c]isoquinolines (3a–3h) and 1,2,3-triazole-coupled pyrimido[4,5-c]isoquinolines (4a–4h) were synthesized in good to excellent yields in the one-pot method.
Sirassu Narsimha (2831663) +2 more
core +1 more source
Table4_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.XLS [PDF]
, 2022 Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081) +8 more
core +1 more source
Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle
Chemistry – A European Journal, EarlyView.Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou +4 more
wiley +1 more source
Strategic Fusion: 1,2,3-Triazole Hybrids as Next-Generation Dual/Multi-Targeted Anticancer Agents – A 2025 Perspective [PDF]
Records of Pharmaceutical & Biomedical SciencesThe strategic hybridization of the 1,2,3-triazole scaffold with diverse bioactive pharmacophores has emerged as a pivotal strategy to overcome multidrug resistance (MDR) in cancer.
Heba Ashour +4 more
doaj +1 more source