Results 91 to 100 of about 50,268 (236)

Synthesis of oligonucleotide analogues for use in DNA nanostructures [PDF]

, 2010
Thanks to its ability to form duplexes through selective base-pair recognition, DNA is aunique material for orderly self-assembled construction at the nanoscale. To develop ananotechnology platform on a grid of addressable molecular building blocks using
Durand, Adeline
core  

Table2_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.XLSX [PDF]

, 2022
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081), Jie Zhao (49409), Ge Sun (332789), Jianxue Yang (11590054), Shuxiang Xu (11676219), Miaomiao Yuan (2005606), Wenjing Deng (7538348), Longfei Mao (9683276), Kaitai Yao (87945)   +8 more
core   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Síntese e caracterização de novos materiais funcionais contendo 1,2,4-oxadiazol, 1,3,4-oxadiazol e 1,2,3-triazol [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2014Neste trabalho de tese de doutorado são apresentadas as sínteses ecaracterizações de três novas ...
Girotto, Edivandro
core  

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Reduced Symmetry Metal–Organic Cage‐to‐Framework Materials

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
A series of Ag(I) MOFs was synthesised from organic cages of varying structure and symmetry as linkers. Minor variations in the cage linkers were shown to significantly influence the structures of the resulting MOFs. This work represents the first incorporation of reduced symmetry (including chiral), intrinsically porous building blocks into MOFs, and ...
Cameron J. T. Cox, Aaron H. Bernardino, Louise Male, Rebecca L. Greenaway, Georgia R. F. Orton, James E. M. Lewis   +5 more
wiley   +2 more sources

Amino acid vectorization of salicylic acid enables efficient activation of NPR1‐dependent defense without phytotoxicity

Pest Management Science, EarlyView.
Amino acid‐vectorized salicylic acid activates PR1/NPR1‐dependent defenses without phytotoxicity, showing an efficient strategy for controlled delivery and enhanced plant immunity. Abstract BACKGROUND Addressing global food security under rapid population growth and climate change requires sustainable strategies to protect crops from pathogens while ...
Ruth Oussou, Benoit Guichard, Loïc Lemée, Vincent Lebeurre, Cécile Marivingt‐Mounir, Jean‐François Chollet, Sylvain La Camera   +6 more
wiley   +1 more source

Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Novel halogenated purines and pseudopurines with diverse aryl-substituted 1,2,3-triazoles were prepared. While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit unselective activity on
Andrea Bistrović, Petra Grbčić, Anja Harej, Mirela Sedić, Sandra Kraljević-Pavelić, Sanja Koštrun, Janez Plavec, Damjan Makuc, Silvana Raić-Malić   +8 more
doaj   +1 more source

Sensitive Energetics from the N‐Amination of 4‐Nitro‐1,2,3‐Triazole

ChemistryOpen, 2020
Energetic N‐amino‐C‐nitro compounds 1‐amino‐4‐nitro‐1,2,3‐triazole and 2‐amino‐4‐nitro‐1,2,3‐triazole are characterized for the first time as energetic materials. These compounds were characterized chemically by nuclear magnetic resonance (NMR), Infrared
Dominique R. Wozniak, Benjamin Salfer, Dr. Matthias Zeller, Dr. Edward F. C. Byrd, Prof. Davin G. Piercey   +4 more
doaj   +1 more source

CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview

Beilstein Journal of Organic Chemistry, 2023
Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of
Dileep Kumar Singh
doaj   +1 more source