Results 91 to 100 of about 8,430 (199)

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Synthesis of Functionalized 1H-Imidazoles via Denitrogenative Transformation of 5-Amino-1,2,3-Triazoles

Molecules
An efficient access to novel 2-substituted 1H-imidazole derivatives was developed based on acid-mediated denitrogenative transformation of 5-amino-1,2,3-triazole derivatives available through dipolar azide−nitrile cycloaddition (DCR).
Pavel S. Gribanov, Anna N. Philippova, Alexander F. Smol’yakov, Diana N. Tukhvatullina, Viktoria A. Vlasova, Maxim A. Topchiy, Andrey F. Asachenko, Sergey N. Osipov   +7 more
doaj   +1 more source

A Regioselective Approach to Accessing Trisubstituted Pyrrolo[2,3-d][1,2,3]triazoles via an Orthogonal Protection Strategy

Molecules
The first access to N-2, N-4-disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported herein. The series was generated using an orthogonal protecting group strategy from N-1, N-4-disubtituted pyrrolo[2,3-d][1,2,3]triazoles. N-Arylation by Ullman–Goldberg
Kévin Brugemann, Simon Garnier, Johnny Vercouillie, Sylvain Routier, Frédéric Buron   +4 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Synthesis and Evaluation of Molecular Docking and Anti-Inflammatory Activity of New 1,2,3-Triazole Derivatives

Journal of Chemistry
In this study, a series of novel substituted Ph-1,2,3-triazole derivatives 7(a–k) were synthesised via a combination of cycloaddition reactions, Click chemistry approach and Pd-catalysed Suzuki–Miyaura coupling.
Shalini Aitha, Bhookya Shankar, Raghavender Matta, Manda Srinivas, Jalapathi Pochampally   +4 more
doaj   +1 more source

BIOLOGICAL SIGNIFICANCE OF 1,2,3-TRIAZOLES

This thesis examines the biological activity of triazole compounds, with particular emphasis on the physicochemical properties of 1,2,3-triazole and its significance in pharmaceutical drugs. The study analyzes the effects of 1,2,3-triazole derivatives on various biological processes, including their antibacterial and antifungal properties. In addition,
Zakirjonova, Diyora, Fazlidin, Kirgizov
openaire   +1 more source

Biological and In Silico Evaluation of Novel Methoxyphenol-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer's and Anticancer Agents. [PDF]

Chem Biol Drug Des
Onur S, Çeşme M, Tümer F.
europepmc   +1 more source

New 1,2,3-Triazole and Dipyridothiazine Hybrids-Synthesis, Analysis, Cytotoxicity and Molecular Docking. [PDF]

Biomolecules
Martula E, Bagrowska W, Strzyga-Łach P, Struga M, Latocha M, Kuśmierz D, Jeleń M, Morak-Młodawska B.   +7 more
europepmc   +1 more source

Modification of fish oil triglycerides into 1,2,3-triazole-fatty acid esters as potent antitubercular agents. [PDF]

MethodsX
Ardiansah B, Amanda L, Prabandari EE, Wukirsari T, Handayani S.   +4 more
europepmc   +1 more source

Quinobenzothiazine-AZT Hybrids Linked via 1,2,3-Triazole: Rational Design, Synthesis, and Biological Evaluation as Anticancer Agents. [PDF]

Int J Mol Sci
Giercuszkiewicz-Haśnik K, Skonieczna M, Morak-Młodawska B, Jeleń M.   +3 more
europepmc   +1 more source