Results 91 to 100 of about 61,653 (192)

Table5_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.XLS

, 2022
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081), Jie Zhao (49409), Ge Sun (332789), Jianxue Yang (11590054), Shuxiang Xu (11676219), Miaomiao Yuan (2005606), Wenjing Deng (7538348), Longfei Mao (9683276), Kaitai Yao (87945)   +8 more
core   +1 more source

Triazoles as promising small molecules anticancer agents [PDF]

Records of Pharmaceutical & Biomedical Sciences
The 1,2,3-triazole scaffold has emerged as a pivotal heterocyclic motif in medicinal chemistry due to its unique physicochemical properties, synthetic accessibility, and broad spectrum of biological activities. These five-membered nitrogen-rich rings are
Mennatallah Shaheen, Khaled Darwish, Safaa Kishk, Magda Elsayed, Ismail Salama   +4 more
doaj   +1 more source

Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Neil Taylor, João de Sousa‐Lourenço, Ivana Nikić‐Spiegel   +2 more
wiley   +1 more source

DataSheet12_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.zip

, 2022
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081), Jie Zhao (49409), Ge Sun (332789), Jianxue Yang (11590054), Shuxiang Xu (11676219), Miaomiao Yuan (2005606), Wenjing Deng (7538348), Longfei Mao (9683276), Kaitai Yao (87945)   +8 more
core   +1 more source

Biological importance and synthesis of 1,2,3-triazole derivatives: a review

Green Chemistry Letters and Reviews
1,2,3-triazole is a five-member nitrogen-containing heterocyclic compound with diverse biological activities. A number of 1,2,3-triazole-containing FDA-approved drugs are available on the market, and many other pharmaceutically significant potential ...
Mira J. Vaishnani, Sabera Bijani, Mohamed Rahamathulla, Lalji Baldaniya, Vicky Jain, Kamal Y. Thajudeen, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Ismail Pasha   +8 more
doaj   +1 more source

Limiting Trial‐and‐Error: Linker‐Based 2D Descriptor Analysis to Support Very Early Proteolysis‐Targeting Chimeras Design

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Can simple linker descriptors guide PROTAC design? Analysis of matched CRBN‐ and VHL‐recruiting degraders shows that basic 2D linker properties may capture trends linked to degradation efficiency, in vitro ADME and physicochemical properties. A practical approach to reduce trial‐and‐error in early targeted protein degradation programs. Targeted protein
Giulia Apprato, Serena Traversa, Giulia Caron, Giuseppe Ermondi   +3 more
wiley   +1 more source

Cu-Mediated Expeditious Annulation of Alkyl 3‑Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N²‑Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis

, 2020
Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive.
Jun-An Ma (1393726), Chi Wai Cheung (614393), Hao-Qiang Cao (8398338), Hao-Nan Liu (8398335)   +3 more
core   +1 more source

DataSheet14_Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer.ZIP

, 2022
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are emerging at the vanguard of therapy for non-small-cell lung cancer (NSCLC) patients with EGFR-activating mutations.
Wei Li (7081), Jie Zhao (49409), Ge Sun (332789), Jianxue Yang (11590054), Shuxiang Xu (11676219), Miaomiao Yuan (2005606), Wenjing Deng (7538348), Longfei Mao (9683276), Kaitai Yao (87945)   +8 more
core   +1 more source

Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle

Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou, Jinbiao Jiao, Mathieu Lordez, Jean‐Yves Salpin, Juan Xie   +4 more
wiley   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source