Results 111 to 120 of about 20,375 (237)

Triazolophostins: a library of novel and potent agonists of IP3 receptors. [PDF]

, 2015
IP3 receptors are channels that mediate the release of Ca(2+) from the intracellular stores of cells stimulated by hormones or neurotransmitters. Adenophostin A (AdA) is the most potent agonist of IP3 receptors, with the β-anomeric adenine contributing ...
Konieczny, Vera, Sureshan, Kana M, Taylor, Colin W, Vibhute, Amol M   +3 more
core   +2 more sources

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, Volume 183, Issue 12, Page 3355-3376, June 2026.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

A Comparative Study of Molybdenum Carbonyl and Oxomolybdenum Derivatives Bearing 1,2,3-Triazole or 1,2,4-Triazoles in Catalytic Olefin Epoxidation

Molecules, 2018
The molybdenum(0)-carbonyl-triazole complexes [Mo(CO)3(L)3] [L = 1,2,3-triazole (1,2,3-trz) or 1,2,4-triazole (1,2,4-trz)] have been prepared and examined as precursors to molybdenum(VI) oxide catalysts for the epoxidation of cis-cyclooctene. Reaction of
Lucie S. Nogueira, Patrícia Neves, Ana C. Gomes, Tatiana A. Amarante, Filipe A. Almeida Paz, Anabela A. Valente, Isabel S. Gonçalves, Martyn Pillinger   +7 more
doaj   +1 more source

Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry [PDF]

, 2012
There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several ...
Addepalli, Bramsen, Caruthers, Chandrasekhar, Chevolot, Chittepu, Corey, Crooke, de Miguel, Dierckx, Duschinsky, Dyrager, Eguchi, El-Sagheer, Gutierrez, Inoue, Jayaprakash, Jean-Paul Desaulniers, Kaczmarek, Kuboyama, Kumar, Lachmann, Liu, Montevecchi, Nielsen, Nitin, Ostergaard, Pan, Park, Qing, Robins, Singh, Takarada, Tim Efthymiou, van Delft, Varizhuk, Wagner, Wei Gong, Whiting, Yamada, Yu   +40 more
core   +1 more source

Estrogen Deprivation During Primate (Papio anubis) Pregnancy: Impact on Systemic Microvascular Flow and Cardiovascular Development and Function After Birth in Offspring

Journal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT Background Suppressing estradiol (E2) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin‐mediated glucose uptake, and induces insulin resistance. We examined whether E2 deprivation also impairs microvascular flow and cardiac function.
Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht   +4 more
wiley   +1 more source

“Click” Synthesis of Nonsymmetrical Bis(1,2,3-triazoles)

Organic Letters, 2010
Unsymmetrically 1,1'-disubstituted 4,4'-bis-1H-1,2,3-triazoles 4 have been prepared from 4-ethynyl-1,2,3-triazoles 5 and azides. Following a "double-click" strategy, two complementary approaches were implemented for the preparation of the key 4-ethynyltriazole intermediates 5: (a) the stepwise Swern oxidation/Ohira-Bestman alkynylation of readily ...
Aizpurua, Jesús M., Azcune, Itxaso, Fratila, Raluca M., Balentová, Eva, Sagartzazu-Aizpurua, Maialen, Miranda, José Ignacio   +5 more
openaire   +3 more sources

1,4‐Pentanediol as an Alternative Biomass‐Derived Medium for the Phosphine‐Free Heck Coupling Reactions

ChemSusChem, Volume 19, Issue 9, 14 May 2026.
In this research, a phosphine‐free Heck coupling reaction was performed using biomass‐derived 1,4‐pentanediol and a polar protic solvent. It was demonstrated that a wide scope of products could be isolated by a simple filtration, eliminating the high‐solvent‐consuming column chromatography and reducing the E‐factor by more than 90% compared to ...
Csaba Árvai, László T. Mika
wiley   +1 more source

Synthesis and Cytotoxic Evaluation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones

Anais da Academia Brasileira de Ciências, 2018
The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been pointed out as efficient compounds in anticancer activity studies.
INGRID C. CHIPOLINE, EVELYNE ALVES, PAOLA BRANCO, LETICIA V. COSTA-LOTUFO, VITOR F. FERREIRA, FERNANDO C. DA SILVA   +5 more
doaj   +1 more source

Development of mixed metal metal-organic polyhedra networks, colloids, and MOFs and their pharmacokinetic applications [PDF]

, 2017
The coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra.
Ahmad, Nazir, Chughtai, Adeel H, Danish, Muhammad, Gaoke, Zhang, Van Hecke, Kristof, Verpoort, Francis, Younus, Hussein A   +6 more
core   +2 more sources

Flow Chemistry Meets Green Solvents: Telescoped Synthesis of Triazolyl Phosphoramidates and Phosphinamides in γ‐Valerolactone

ChemSusChem, Volume 19, Issue 9, 14 May 2026.
A telescoped three‐step continuous flow process enables the synthesis of organophosphorus 1,2,3‐triazoles in the biomass‐derived solvent γ‐valerolactone (GVL). The sequence integrates N‐phosphorylation, azidation, and Cu(I)‐catalyzed azide–alkyne cycloaddition (CuAAC), followed by in‐line copper removal, giving diverse triazoles in good to high overall
Viktória Gerő, Dániel Steinsits, Pál Tamás Szabó, Erika Bálint   +3 more
wiley   +1 more source