Results 111 to 120 of about 50,268 (236)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Triazole‐Bridged Dinuclear Ru(II) and Ir(III) Complexes: Photophysics, Electrochemistry, and DFT/TD‐DFT Analysis

ChemistrySelect, Volume 11, Issue 25, 3 July 2026.
Investigations of a click‐built heteroditopic triazole–bipyridyl bridge (L3) and its coordination to Ru(II) and Ir(III) centers are presented as a modular route to dinuclear luminophores and structure–property correlations. ABSTRACT The heteroditopic 1,2,3‐triazole ligand 4‐[4‐(pyridin‐2‐yl)‐1,2,3‐triazol‐1‐yl]‐2,2′‐bipyridine (L3), prepared here ...
Alessandro Sinopoli, Baljinder S. Uppal, Paul A. Scattergood, Paul I. P. Elliott   +3 more
wiley   +1 more source

Triazoles as promising small molecules anticancer agents [PDF]

Records of Pharmaceutical & Biomedical Sciences
The 1,2,3-triazole scaffold has emerged as a pivotal heterocyclic motif in medicinal chemistry due to its unique physicochemical properties, synthetic accessibility, and broad spectrum of biological activities. These five-membered nitrogen-rich rings are
Mennatallah Shaheen, Khaled Darwish, Safaa Kishk, Magda Elsayed, Ismail Salama   +4 more
doaj   +1 more source

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

Biological importance and synthesis of 1,2,3-triazole derivatives: a review

Green Chemistry Letters and Reviews
1,2,3-triazole is a five-member nitrogen-containing heterocyclic compound with diverse biological activities. A number of 1,2,3-triazole-containing FDA-approved drugs are available on the market, and many other pharmaceutically significant potential ...
Mira J. Vaishnani, Sabera Bijani, Mohamed Rahamathulla, Lalji Baldaniya, Vicky Jain, Kamal Y. Thajudeen, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Ismail Pasha   +8 more
doaj   +1 more source

1,1‐and 1,2‐Diborylalkenes: Preparation and Synthetic Applications

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
In this review, we highlight recent advances in the synthesis and reactivity of 1,1‐diborylalkenes and 1,2‐diborylalkenes, along with various transformations leading to C‐C, C‐heteroatom, and multicomponent products. By providing a comprehensive and practical resource, this review aims to assist researchers in exploring the synthetic utility of 1,1 and
Jayaram Vankudoth, Maruti Mali, Fabienne Berrée   +2 more
wiley   +1 more source

Nafion-1,2,3-Triazole Blend Membranes for High Temperature PEMFCs [PDF]

, 2013
Nafion-1,2,3-triazole blend membranes were prepared by autoclave (AC) solution processing mixing of Nafion (R) solution (5% solution in 1- and 2-propanol and H2O) and 1,2,3-triazole.
Kim, J, Divona, M, DI VONA, MARIA LUISA, Jun, M   +3 more
core   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity

Heliyon, 2019
In this study, we report our contribution to the application of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the synthesis of β-keto-1,2,3-triazole derivatives 3a-f from ethinylestradiol and their application in the inhibition of ...
Thayane M. Queiroz, Erika V.M. Orozco, Valdenizia R. Silva, Luciano S. Santos, Milena B.P. Soares, Daniel P. Bezerra, André L.M. Porto   +6 more
doaj   +1 more source

1,2,3-Triazoles as Amide-bond Surrogates in Peptidomimetics

CHIMIA, 2013
1,2,3-Triazoles represent a class of heterocycles with interesting properties for application in peptide sciences since they closely resemble amide bonds while being stable to enzymatic degradation. These characteristics make 1,2,3-triazoles promising candidates as amide-bond surrogates for the development of novel peptidomimetics with ...
Ibai E. Valverde, Thomas L. Mindt
openaire   +5 more sources