Results 81 to 90 of about 19,712 (214)

Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2018
Novel halogenated purines and pseudopurines with diverse aryl-substituted 1,2,3-triazoles were prepared. While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit unselective activity on
Andrea Bistrović   +8 more
doaj   +1 more source

Sensitive Energetics from the N‐Amination of 4‐Nitro‐1,2,3‐Triazole

open access: yesChemistryOpen, 2020
Energetic N‐amino‐C‐nitro compounds 1‐amino‐4‐nitro‐1,2,3‐triazole and 2‐amino‐4‐nitro‐1,2,3‐triazole are characterized for the first time as energetic materials. These compounds were characterized chemically by nuclear magnetic resonance (NMR), Infrared
Dominique R. Wozniak   +4 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

open access: yesChemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati   +4 more
wiley   +1 more source

Dual Ligand‐Enabled Nondirected C─H Olefination of (Hetero)Arenes for the Synthesis of Clickable Derivatives

open access: yesChemistry – A European Journal, EarlyView.
We report an efficient method for late‐stage installation of “clickable” alkyne groups into diverse (hetero)arenes. Using a dual‐ligand palladium catalyst that combines an NASA ligand with an N‐heterocycle, an acrylate unit bearing a terminal alkyne can be introduced via nondirected C─H activation.
Tommaso Braga   +2 more
wiley   +1 more source

Insights into the Nature of Synergistic Effects in Proton-Conducting 4,4−1H,1H-Bitriazole-Poly(ethylene oxide) Composites [PDF]

open access: yes, 2009
A nitrogen-containing heterocycle (NCH), 4,4-1H-1H-bi-1,2,3-triazole (bitriazole), capable of mimicking the hydrogen bonding of water in the solid state is synthesized and its ability to conduct protons in the presence of poly(ethylene oxides) under ...
Alabi, Christopher A.   +3 more
core   +1 more source

Vegetable Oil‐Based Materials for Drug Delivery Systems and Wound Dressings

open access: yesMacromolecular Bioscience, EarlyView.
Renewable resources like vegetable oils are increasingly explored for biomaterial production in biomedical applications. Their monoglycerides and triglycerides inherently possess functions or can be chemically modified to introduce functional groups suitable for polymerization, yielding biomaterials with desirable properties such as flexibility ...
Lucas M. Favre   +2 more
wiley   +1 more source

Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.

open access: yesPLoS ONE, 2013
Triazoles are known for their non-toxicity, higher stability and therapeutic activity. Few nucleoside (L1, L2 and L3) and non-nucleoside 1,2,3-triazoles (L4-L14) were synthesised using click chemistry and they were screened for tumor cell cytotoxicity ...
Jerald Mahesh Kumar   +10 more
doaj   +1 more source

4-Benzyl-1-(4-nitrophenyl)-1H-1,2,3-triazole: crystal structure and Hirshfeld analysis [PDF]

open access: yes, 2017
The mol­ecule in the title compound, C15H12N4O2, has a twisted L-shape with the dihedral angle between the aromatic rings of the N-bound benzene and C-bound benzyl groups being 70.60 (9)°. The nitro group is co-planar with the benzene ring to which it is
Ali, Akbar   +5 more
core   +2 more sources

Precise Tailoring of the Coordination Environment of Single‐Atom Cu(I) on Trifurcate AlL3 Supports for Click Chemistry

open access: yesRare Metals, EarlyView.
ABSTRACT Single‐atom catalysis hinges on fundamental challenges in precisely controlling metal‐support interactions and rationally regulating metal–adsorbate relationships. Herein, we report a universal strategy for constructing highly efficient and well‐defined Cu(I) single‐atom catalysts based on a trifurcate AlL3 molecular support.
Donghui Zhang   +9 more
wiley   +1 more source

Recent advances in the synthesis of triazole derivatives [PDF]

open access: yes, 2015
Triazole ring system has attracted a continuously growing interest of synthetic organic chemists and those dealing with the medicinal compounds due to its versatile potential to interact with biological systems.
Ahmad, Matloob   +6 more
core  

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