Results 11 to 20 of about 94,532 (279)
Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines
Molecules, 2022 Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. Two typical modes of constructing these heterocyclic ring systems are cyclizing a heterocyclic diamine with a nitrite or ...
Gavin R. Hoffman, Allen M. Schoffstall
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1,2,3-Triazoles as Amide-bond Surrogates in Peptidomimetics
CHIMIA, 2013 1,2,3-Triazoles represent a class of heterocycles with interesting properties for application in peptide sciences since they closely resemble amide bonds while being stable to enzymatic degradation.
Ibai E. Valverde, Thomas L. Mindt
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Reaction of 4-acetyl-1,2,3-triazol-5-olate with hydrazine derivatives [PDF]
Chimica Techno Acta, 2015 1,2,3-triazole attracts attention because of the ability opening ring to form α-diazoimin and intramolecular rearrangements with the formation of various heterocyclic systems.
I. S. Khazhieva +2 more
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Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles [PDF]
Tetrahedron Chem, 2022 The synthesis and characterisation of axially chiral atropisomeric 1,5-disubstituted 1,2,3-triazoles is reported. Molecules designed to display restricted rotation about 1,2,3-triazole N-1-aryl or 1,2,3-triazole C-5-aryl bonds were investigated by ...
Fernanda Meloni +6 more
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Alkyne-Azide Cycloaddition Catalyzed by Silver Chloride and “Abnormal” Silver N-Heterocyclic Carbene Complex [PDF]
The Scientific World Journal, 2013 A library of 1,2,3-triazoles was synthesized from diverse alkynes and azides using catalytic amounts of silver chloride instead of copper compounds. In addition, a novel “abnormal” silver N-heterocyclic carbene complex was tested as catalyst in this ...
Aldo I. Ortega-Arizmendi +2 more
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1,2,3-Triazoles and their metal chelates with antimicrobial activity. [PDF]
Front Chem, 2023 The emergence of drug-resistant bacterial and fungal pathogens has highlighted the urgent need of innovative antimicrobial therapeutics. Transition metal complexes with biologically active ligands (coumarins, terpyridines, triazoles, uracils, etc.) have long been investigated for antimicrobial activity.
Todorov L, Kostova I.
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A practical flow synthesis of 1,2,3-triazoles. [PDF]
RSC Adv, 2022 Copper-on-charcoal is an excellent heterogeneous catalyst for the alkyne–azide cycloaddition reaction performed under continuous flow conditions. 2-Ynoic acids undergo decarboxylation/cycloaddition cascade giving triazoles bearing small alkyl chains.
Drelinkiewicz D, Whitby RJ.
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Antimicrobial studies of unsymmetrical bis-1,2,3-triazoles [PDF]
Organic and Medicinal Chemistry Letters, 2012 Aryl azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted butynyl 1,2,3-triazoles in a domino fashion, which upon Cu(I) catalyzed 1,3-dipolar cycloaddition with aryl azides afforded novel bis-1,2,3-triazoles in quantitative yields.
Bashir A. Ganai +2 more
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1,2,3-Triazoles: Controlled Switches in Logic Gate Applications. [PDF]
Sensors (Basel), 2023 A 1,2,3-triazole-based chemosensor is used for selective switching in logic gate operations through colorimetric and fluorometric response mechanisms. The molecular probe synthesized via “click chemistry” resulted in a non-fluorescent 1,4-diaryl-1,2,3-triazole with a phenol moiety (PTP).
Ghosh D +7 more
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1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs
International Journal of Molecular Sciences, 2022 Fibrinolysis is a natural process that ensures blood fluidity through the removal of fibrin deposits. However, excessive fibrinolytic activity can lead to complications in different circumstances, such as general surgery or severe trauma. The current antifibrinolytic drugs in the market, aminocaproic acid (EACA) and tranexamic acid (TXA), require high ...
Oriol Bosch-Sanz +7 more
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