Results 111 to 120 of about 89,598 (163)

Kondensierte Dihydro‐1,2,4‐triazine

Archiv der Pharmazie, 1987
AbstractHydrazone von α‐Aminoketonen mit cyclischem Aminanteil ergeben mit Quecksilber (II)‐EDTA eine Cyclodehydrierung zu entspr. kondensierten Dihydrotriazinen.
Hans Möhrle, Peter Schillings
openaire   +1 more source

Anionic cascade recyclization of pyrazolo[5,1-c][1,2,4]triazines to pyrrolo[1,2-b][1,2,4]triazine and [1,2,4]triazino[2′,3′:1,5]pyrrolo[3,2-c]isoquinoline systems

, 2020
The treatment of tert-butyl 2-(7-bromo-3-tert-butyl-8-R-4-oxopyrazolo[5,1-c][1,2,4]triazin-1(4H)-yl)acetates (R = CN, CO2Et, NO2) with alkyl lithiums in THF at low temperature led to rapid cascade reactions with the formation of tert-butyl 7-amino-3-tert-
S. M. Ivanov
semanticscholar   +1 more source

1,6-Dihydro-1,2,4-triazines

J. Chem. Soc., Perkin Trans. 1, 1976
Synthetic pathways to reduced 1,2,4-triazines have been investigated. The most convenient route involved the reaction of ketones with sodium cyanide and thiosemicarbazide, under acidic conditions, to yield cyanothiosemi-carbazones. These compounds were either converted into the corresponding carboxy-thiosemicarbazones which, in turn, were cyclized in ...
Louis C. March, Khizar Wasti, Madeleine M. Joullié   +2 more
openaire   +1 more source

Synthesis, biological evaluation, and docking studies of novel 5,6-diaryl-1,2,4-triazine thiazole derivatives as a new class of α-glucosidase inhibitors.

Bioorganic chemistry (Print), 2018
A novel 5,6-diaryl-1,2,4-triazine thiazole derivatives (7a-7q) were synthesized and characterized by 1H NMR and 13C NMR and evaluated for their α-glucosidase inhibitory activity.
Guangcheng Wang, Zhiyun Peng, Zipeng Gong, Yongjun Li   +3 more
semanticscholar   +1 more source

Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo[2,1-f][1,2,4]triazine derivatives.

Bioorganic & Medicinal Chemistry Letters, 2020
A series of 6-aminocarbonyl pyrrolo[2,1-f][1,2,4]triazine derivatives were designed by scaffold hopping strategy. The IC50 values of compound 14a against PI3Ks were measured, showing selective activity against p110α and p110δ with IC50s of 122 nM and 119 
H. Xiang, Yanhong Chen, Yi Wang, Xi Zhang, Jian Ding, Linghua Meng, Chun-hao Yang   +6 more
semanticscholar   +1 more source

Merocyaninfarbstoffe aus 1,2,4-Triazin

Monatshefte für Chemie, 1968
Hydrazinderivate von 1,2,4-Triazinen liefern mit Acetessigester Pyrazolonderivate. Diese kondensieren sich mit Salzen quartarer heterocyclischer Basen zu Merocyaninfarbstoffen. Darstellung und Spektren von drei Typen solcher Farbstoffe werden beschrieben.
Engelbert Kiša, Jaromír Hadáček
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1,2,4-triazines and condensed derivatives—XIV

Tetrahedron, 1974
Abstract 3 - Alkylthio - 6,7 - dihydro - [1.2.4]triazino - [1.6-c]quinazolin - 5 - ium - 1 - olates (3), prepared by condensation of 3 - alkylthio -6-(2- aminophenyl) - 1,2,4 - triazin - 5(2H) - ones (1) with aldehydes, ketones or their equivalents are transformed by thermolysis and/or acid treatment into 3 - alkylthio - [1.2.4]triazino[5.6-b]indoles
G. Doleschall, K. Lempert
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1,2,4-Triazines Are Versatile Bioorthogonal Reagents

Journal of the American Chemical Society, 2015
A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO). The enhanced stability of the triazine scaffold enabled its direct use in recombinant protein production.
David N, Kamber, Yong, Liang, Robert J, Blizzard, Fang, Liu, Ryan A, Mehl, K N, Houk, Jennifer A, Prescher   +6 more
openaire   +2 more sources

Exploration of novel pyrrolo[2,1-f][1,2,4]triazine derivatives with improved anticancer efficacy as dual inhibitors of c-Met/VEGFR-2.

European journal of medicinal chemistry, 2018
c-Met and VEGFR-2 have attracted interest as novel targets for treatment of various cancers. Aiming to develop potent dual c-Met and VEGFR-2 inhibitors, a series of pyrrolo[1,2-f][1,2,4]triazine derivatives were designed and synthesized.
W. Shi, Hao Qiang, Dandan Huang, Xinzhou Bi, Wen-long Huang, Hai Qian   +5 more
semanticscholar   +1 more source

Zur Chemie der 1,2,4‐Triazine, VII. Reaktionen von 1,2,4‐Triazin‐4‐oxiden

Justus Liebigs Annalen der Chemie, 1976
AbstractDie Hydrolyse von 1,2,4‐Triazin‐4‐oxiden 1 verlauft sowohl im sauren als auch im basischen Milieu unter Ringöffnung. Die Oxidation von 1 ergibt 5‐0xo‐1,2,4‐triazin‐4‐oxide 7 und/oder 1,2,4‐Triazin‐1,4‐dioxide 8. Bei der Reaktion von 1 mit Benzoylchlorid in Gegenwart von Wasser werden 1,2,4‐Triazin‐5‐one 5 gebildet.
Hans Neunhoeffer, Volker Böhnisch
openaire   +1 more source