Results 11 to 20 of about 89,598 (163)

Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in men and in women. The impact of the new pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide (MM-129) was evaluated against human colon cancer in vitro and in zebrafish
Justyna Magdalena Hermanowicz, Anna Szymanowska, Beata Sieklucka, Robert Czarnomysy, Krystyna Pawlak, Anna Bielawska, Krzysztof Bielawski, Joanna Kalafut, Alicja Przybyszewska, Arkadiusz Surazynski, Adolfo Rivero-Muller, Mariusz Mojzych, Dariusz Pawlak   +12 more
doaj   +2 more sources

Synthesis, Characterization, and Biological Evaluation of Novel 7-Oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic Acid Derivatives

Molecules, 2020
A series of novel 7-oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic acid derivatives was synthesized in good yields by a multi-step procedure that included the generation of the S-alkylated derivatives from 6-substituted arylmethyl-3-mercapto-1,2,4 ...
Dong Cai, Tai Li, Qian Xie, Xiaofei Yu, Wei Xu, Yu Chen, Zhe Jin, Chun Hu   +7 more
doaj   +2 more sources

Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity

Heteroatom Chemistry, 2019
1,2,4-Triazine and 1,2,5-oxadiazine derivatives 2–12 were obtained from treated 1,3-oxazolone (1) with phenyl hydrazine or hydroxylamine hydrochloride.
Heba E. Hashem, Ahmed M. Abo-Bakr
doaj   +2 more sources

Preparation of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides and Their Experimental and Computational Biological Studies

International Journal of Molecular Sciences, 2022
Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides constitute a novel class of heterocyclic compounds with broad biological activity, including anticancer properties.
M. Kciuk, S. Mujwar, A. Szymanowska, B. Marciniak, K. Bukowski, M. Mojzych, R. Kontek   +6 more
semanticscholar   +1 more source

Synthesis and evaluation of the antioxidant activity of new spiro-1,2,4-triazine derivatives applying Ag/Fe3O4/CdO@MWCNT MNCs as efficient organometallic nanocatalysts

Frontiers in Chemistry, 2022
We applied the Petasites hybridus rhizome water extract as green media so that Ag/Fe3O4/CdO@ multi-walled carbon nanotubes magnetic nanocomposites (Ag/Fe3O4/CdO@MWCNTs MNCs) could be prepared.
E. Ezzatzadeh, S. Soleimani‐Amiri, Zinatossadat Hossaini, Khatereh Khandan Barani   +3 more
semanticscholar   +1 more source

Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma

Marine Drugs, 2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer, characterized by late prognosis and drug resistance. Among the main factors sustaining PDAC progression, the alteration of cell metabolism has emerged to have a key ...
D. Carbone, Michele De Franco, Camilla Pecoraro, Davide Bassani, Matteo Pavan, S. Cascioferro, B. Parrino, G. Cirrincione, S. Dall'acqua, S. Sut, S. Moro, V. Gandin, P. Diana   +12 more
semanticscholar   +1 more source

Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.

European journal of medicinal chemistry, 2021
Based on the observed pharmacophoric structural features for the reported dual COX/15-LOX inhibitors and inspired by the abundance of COX/LOX inhibitory activities reported for the 1,2,4-triazine and quinoline scaffolds, we designed and synthesized novel
Amany M. Ghanim, S. Rezq, T. Ibrahim, D. Romero, Hend Kothayer   +4 more
semanticscholar   +1 more source

The Anticancer Action of a Novel 1,2,4-Triazine Sulfonamide Derivative in Colon Cancer Cells

Molecules, 2021
Cancer therapy is one of the most important challenges of modern medical and chemical sciences. Among the many methods of combating cancer, chemotherapy plays a special role.
Agnieszka Gornowicz, A. Szymanowska, M. Mojzych, R. Czarnomysy, K. Bielawski, A. Bielawska   +5 more
semanticscholar   +1 more source

Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy

Medicinal Chemistry Research, 2021
Cancer is the second leading cause of death worldwide responsible for about 10 million deaths per year. To date several approaches have been developed to treat this deadly disease including surgery, chemotherapy, radiation therapy, hormonal therapy ...
Sarbjit Singh, Divya Utreja, Vimal Kumar
semanticscholar   +1 more source

3-Methylsulfanyl-5-phenyl-1,2,4-triazine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2014
In the molecule of the title compound, C10H9N3S, the dihedral angle between the triazine and phenyl rings is 11.77 (7)°. In the crystal, molecules are linked by π–π stacking interactions [centroid–centroid distances = 3.7359 (3) and 3.7944 (4) Å], forming layers parallel to thebcplane.
Salha Hamri, Abderrafia Hafid, Mostafà Khouili, Lahcen El Ammari, El Mostafa Ketatni   +4 more
openaire   +3 more sources