Results 21 to 30 of about 89,598 (163)

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir

Organic Process Research & Development, 2021
Pyrrolo[2,1-f][1,2,4]triazine (1) is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound 1 was produced through a newly developed synthetic methodology utilizing simple building blocks such as pyrrole ...
Sarabindu Roy, A. Yadaw, Subho Roy, G. Sirasani, Aravind S. Gangu, Jack D. Brown, J. Armstrong, R. Stringham, B. Gupton, C. Senanayake, D. Snead   +10 more
semanticscholar   +1 more source

2-(3-Chloro-5,6-diphenyl-2,5-dihydro-1,2,4-triazin-5-yl)-2-methylpropanenitrile

Acta Crystallographica Section E, 2012
The title compound, C19H17ClN4, was obtained from the reaction of 3-chloro-5,6-diphenyl-1,2,4-triazine with isobutyronitrile in the presence of lithium diisopropylamide as an unexpected product of covalent addition of isobutyronitrile carbanion to the C ...
Ewa Wolińska, Zbigniew Karczmarzyk, Andrzej Rykowski, Zofia Urbańczyk-Lipkowska, Przemysław Kalicki   +4 more
doaj   +1 more source

Reactions of 3-amino-1,2,4-triazine with coupling reagents and electrophiles

Heterocyclic Communications, 2022
Analogs of a new heterocyclic system were obtained from the reactions of 3-amino-1,2,4-triazine with coupling reagents such as boronic acids, and terminal alkynes in the presence of a palladium catalyst.
Bvumbi Mpelegeng Victoria, Nemudzivhadi Anza Imanuel, Sengane Musiiwa Victoria, Moleele Simon Mnyakeni   +3 more
doaj   +1 more source

An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy

Beilstein Journal of Organic Chemistry, 2016
An effective and highly regio- and diastereoselective one-pot method for the synthesis of new polynuclear dispiroheterocyclic systems with five stereogenic centers (dispiro[imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-6,3′-pyrrolidine-2′,3′′-indoles ...
Alexei N. Izmest’ev, Galina A. Gazieva, Natalya V. Sigay, Sergei A. Serkov, Valentina A. Karnoukhova, Vadim V. Kachala, Alexander S. Shashkov, Igor E. Zanin, Angelina N. Kravchenko, Nina N. Makhova   +9 more
doaj   +1 more source

The Reaction of 1,6-Diamino-4-aryl-2-oxo-1,2-dihydropyridine- 3,5-Dicarbonitriles with Certain Electrophilic Agents

Chemistry Proceedings, 2023
The reaction of 1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles, which are easily available through the reaction of cyanoacetohydrazide with arylmethylene malononitriles, with ninhydrin leads to the formation of novel dihydroindeno[1,2-e]pyrido[
Alexei A. Dolganov, Alexandra R. Chikava, Victor V. Dotsenko   +2 more
doaj   +1 more source

An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds.

European journal of medicinal chemistry, 2017
The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides, N,N'-dioxides as well as the benzo- and hetero-fused systems are reported.
S. Cascioferro, B. Parrino, V. Spanò, A. Carbone, A. Montalbano, P. Barraja, P. Diana, G. Cirrincione   +7 more
semanticscholar   +1 more source

Ring Transformation of Oxazolo [3,2-b][1,2,4] Triazines [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1995
6-Methyl-2-phenyl-7H-Oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2).
Majid M. Heravi, Mehdi Bakavoli, Zohreh Sadjadi Hashemi   +2 more
doaj  

The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells

International Journal of Molecular Sciences, 2020
The discovery of cytotoxic drugs is focused on designing a compound structure that directly affects cancer cells without an impact on normal cells. The mechanism of anticancer activity is mainly related with activation of apoptosis.
Agnieszka Gornowicz, A. Szymanowska, M. Mojzych, K. Bielawski, A. Bielawska   +4 more
semanticscholar   +1 more source

Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles

Molecules, 2000
It describes the regioselectivity studies of 5,6-Dimethyl-1,2,4-triazine-N4-oxide using different electrophiles.
H. Cerecetto, M. González, P. Saenz, G. Seoane   +3 more
doaj   +1 more source

6-Amino-3,4-dimethyl-1,2,4-triazin-1-ium 2-anilinobenzoate–3-amino-5,6-dimethyl-1,2,4-triazine (1/1)

IUCrData, 2017
In the title molecular salt, C5H9N4+·C13H10NO2−·C5H8N4, the asymmetric unit consists of a 6-amino-3,4-dimethyl-1,2,4-triazin-1-ium cation, a 2-anilinobenzoate anion and a neutral 3-amino-5,6-dimethyl-1,2,4-triazine molecule. The typical intramolecular N..
Ramalingam Sangeetha, Kasthuri Balasubramani, Kaliyaperumal Thanigaimani, Ibrahim Abdul Razak   +3 more
doaj   +1 more source