Results 31 to 40 of about 3,168 (197)

Syntheses of Diheterocyclic Compounds Based on 2-Thioacetohydrazide-5,7-dimethyl-1,2,4-triazolo[1,5-a]- pyrimidine

Molecules, 2008
The syntheses of some diheterocyclic compounds from 2-thioacetohydrazide- 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (1) are described. Compound 1 can be converted into triazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles.
Guang-Fu Yang, Hai-Yang Tu, Chao-Nan Chen, Qiong Chen, Zu-Ming Liu   +4 more
doaj   +1 more source

Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors.
Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed   +11 more
doaj   +1 more source

Synthesis and Crystal Structure Analysis of 2-(Fluorobenzyl)-6-(4-Nitrophenyl) Imidazo[2,1-b][1,3,4]Thiadiazole [PDF]

, 2010
Preparation of 2-(4-fluorobexzyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole is described and its crystal structure is discussed. The compound crystallizes in the monoclinic space group C2/c with a = 39.941(6) Å, b = 5.698(2) Å, c = 13.272(5) Å β =
Banu, A., Begum, N.S., Khazi, I.M., Lamani, R.S.   +3 more
core   +1 more source

Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation

Molecules, 2011
Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl-1H-indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination of 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H ...
Sobhi M. Gomha, Sayed M. Riyadh
doaj   +1 more source

Synthesis and Screening of Substituted Thiadiazoles Against Gleophyllum Straitum

E-Journal of Chemistry, 2004
Cyclocondensation of a series of substituted phenoxy methylene carboxylic acids with thiosemoicarbazides afforded 2-Amino-5-Aryloxy Methylene –1,3,4 Thiadiazoles (Ia-Ie).
M. G. H. Zaidi, Seema Zaidi, I. P. Pandey   +2 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives

Molecules, 2012
New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 with N-phenyl 2-oxopropanehydrazonoyl chloride (2) in dioxane in the presence of triethylamine.
Mohamed R. Abdel Aziz, Magda A. Abdallah, Thoraya A. Farghaly   +2 more
doaj   +1 more source

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain [PDF]

, 2016
The antiapoptotic protein BCL 2 is overexpressed in several cancers and contributes to prolonged cell survival and chemoresistance, lending itself as an excellent target for cancer therapy.
Anderson, Arkin, Beauchard, Campos, Case, Chiruvella, Cho, Cotter, Dai, Delft, el-Sherbeny, Fedorov, Ferri, Gross, Gutierrez-Puente, Hanada, Iyer, Karki, Kavitha, Kavitha, Kavitha, Khaw, Kirkin, Kitada, Kolluri, Konopleva, Kumar, Lin, Lotem, Marschitz, Mologni, Moorthy, Morris, Nambiar, Nedelkina, Niesen, Oakes, Pan, Pentimalli, Real, Reed, Rosen, Shahabuddin, Shangary, Sharma, Souers, Srivastava, Srivastava, Trott, Vaillant, Vedadi, Vogler, Wang, Wang, Wang, Willis, Wlodkowic, Zhai   +57 more
core   +1 more source

Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review [PDF]

Molecules, 2020
During recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new antitumor agents. One of them is 1,3,4-thiadiazole. This study is an attempt to collect the 1,3,4-thiadiazole and its derivatives, which can be considered as potential anticancer agents, reported ...
Sara Janowska, Agata Paneth, Monika Wujec   +2 more
openaire   +3 more sources

Recent synthetic strategies of medicinally important imidazothiadiazoles

Journal of Saudi Chemical Society, 2023
Imidazothiadiazole is a fundamental fused heterocyclic compound containing imidazole and thiadiazole ring systems. This versatile framework has significant applications in pharmaceutical chemistry and also possessed a remarkable biological profile.
Tooba Jabeen, Sana Aslam, Muhammad Yaseen, Muhammad Jawwad Saif, Matloob Ahmad, Sami A. Al-Hussain, Magdi E.A. Zaki   +6 more
doaj   +1 more source

Crystal structure of 5-(adamantan-1-yl)-3-= (4-chloroanilino)methyl-2,3-dihydro-1,3,4-oxadiazole-2-thione, C19H22ClN3OS [PDF]

, 2016
C19H22ClN3OS, orthorhombic, P212121 (no. 19), a = 7.0418(2) Å, b = 10.8802(3) Å, c = 23.5506(6) Å, V = 1804.36(8) Å3, Z = 4, R gt (F) = 0.0413, wR ref (F 2
Al-Alshaikh, M. A., Al-Tamimi, A. M. S., El-Emam, A. Ali, García-Granda, Santiago, Ghabbour, H. A., Said Mohammed Abdelbaky, Mohammed   +5 more
core   +1 more source