Results 61 to 70 of about 1,311 (155)

A Drug Delivery to Improve Prognosis of Traumatic Brain Injury Mice Through Mouse‐Derived Nerve Growth Factor Coated by a Nanoparticle

CNS Neuroscience &Therapeutics, Volume 31, Issue 10, October 2025.
This study is the first to demonstrate that mNGF, when nanocrystallized, crosses the BBB more effectively in TBI mice, subsequently aiding the repair and functional recovery of the nervous system post‐injury. ABSTRACT Objective The large molecular weight and limited permeability of mouse‐derived nerve growth factor (mNGF) across the blood–brain barrier
Ruichen Zhao, Shiying Dong, Di Wu, Yu Tian, Jiangyuan Yuan, Liang Mi, Chenrui Wu, Shiao Tong, Rongcai Jiang   +8 more
wiley   +1 more source

Functionalization of 2-Mercapto-5-methyl-1,3,4-thiadiazole: 2-(ω-Haloalkylthio) Thiadiazoles vs. Symmetrical Bis-Thiadiazoles

Molecules
A study on the functionalisation of 2-mercapto-5-methyl-1,3,4-thiadiazole has been conducted, yielding two series of products: 2-(ω-haloalkylthio)thiadiazoles and symmetrical bis-thiadiazoles, with variable chain lengths. The experimental conditions were
Zhanina S. Petkova, Rusi I. Rusew, Boris L. Shivachev, Vanya B. Kurteva   +3 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines

Molecules, 2016
A novel series of 1,3,4-thiadiazoles, 5-arylazothiazoles and hexahydropyrimido-[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines were synthesized via reaction of hydrazonoyl halides with each of alkyl carbothioates, carbothioamides and 7-thioxo-5,6,7,8 ...
Abdou O. Abdelhamid, Ibrahim E. El Sayed, Mohamed Z. Hussein, Mangoud M. Mangoud   +3 more
doaj   +1 more source

Fibrous Pb(II)‐Based Coordination Polymer Operable as a Photocatalyst and Electrocatalyst for High‐Rate, Selective CO2‐to‐Formate Conversion

Advanced Functional Materials, Volume 35, Issue 28, July 10, 2025.
A coordination polymer [Pb(tadt)]n prepared by a microwave‐assisted solvothermal method selectively reduces CO2 into formate under visible light with a high apparent quantum yield of ≈25% at 400 nm. It can function as a pre‐catalyst, along with conductive Ketjen Black, to form an active PbCO3/Pb3(CO3)2(OH)2 mixture that exhibits a high Faradaic ...
Chomponoot Suppaso, Ryosuke Nakazato, Shoko Nakahata, Yoshinobu Kamakura, Fumitaka Ishiwari, Akinori Saeki, Daisuke Tanaka, Kazuhide Kamiya, Kazuhiko Maeda   +8 more
wiley   +1 more source

Synthesis and Preliminary Antimicrobial Study of 2-Amino-5-Mercapto-1,3,4-Thiadiazole Derivatives

Iraqi Journal of Pharmaceutical Sciences, 2017
Nitrogen heterocycles are of a special interest because they constitute an important class of natural and non natural products, many of which exhibit useful biological activities.Among these nitrogen heterocycles are 1, 3, 4-thiadiazole containing ...
Husam A. Ameen, Ahlam J. Qasir
doaj   +3 more sources

In Vitro and In Silico Evaluation of Isatin‐Derived Spirooxindoles as Antituberculosis Drug Candidates

Chemical Biology &Drug Design, Volume 106, Issue 1, July 2025.
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
Fernanda Rodrigues de Lima, Jéssika de Oliveira Viana, Aleff Cruz de Castro, Rodrigo Cristiano, Marcia Alberton Perelló, Alexia de Matos Czeczot, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso, Claudio Gabriel Lima‐Junior, Valnês da Silva Rodrigues‐Junior, Karen Cacilda Weber   +11 more
wiley   +1 more source

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

Drug Design, Development and Therapy, 2018
Georgeta Serban,1,* Oana Stanasel,2,* Eugenia Serban,3 Sanda Bota2,* 1Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania; 2Chemistry Department, Faculty of Sciences, University of Oradea, Oradea,
Serban G, Stanasel O, Serban E, Bota S
doaj  

Synthesis and biological activity of 5-nitrofuran-containing (1,3,4-thiadiazol-2-yl)piperazine moieties as a new type of anti-Helicobacter pylori heterocycles [PDF]

Journal of the Serbian Chemical Society, 2011
In order to find new and potent drug candidates for the treatment of Helicobacter pylori infections‚ in this study attention was focused on the synthesis and anti-H.
ABBAS SHAFIEE, ESKANDAR ALIPOUR, MARYAM OMRANI, MOHSEN VOSOOGHI, FARIDEH SIAVOSHI, MARYAM NAKHJIRI, SAEED EMAMI, SEYED ESMAEIL SADAT-EBRAHIMI, AZADEH YAHYA-MEYMANDI, MOHAMMAD HASSAN MOSHAFI, ALIREZA FOROUMADI   +10 more
doaj  

Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles

Molecules, 2002
3-(2-Furanyl)-4-amino-5-mercapto-1,2,4-triazole (1) was prepared from 2-furoic acid through a multi-step reaction sequence. Compound 1 reacted with aromatic acids in the presence of phosphorus oxychloride to give 3-(2-furanyl)-6-aryl-1,2,4-triazolo[3,4-b]
Zi-Yi Zhang, Dong-Yong Chen, Xiang-Yun Nan, Xin-Xiang Lei, Xian-Xing Chen, An-Jiang Zhang, Li-Xue Zhang   +6 more
doaj   +1 more source

New derivatives of 2-R1-N-(5-R)-1,3,4-thiadiazol-2-yl-benzolsulfonamides: synthesis, physicochemical properties and biological activity prediction

Annals of Mechnikov's Institute, 2020
Introduction: The analysis of modern literature, including overseas one, showed that a lot of the scientific researches is devoted to finding and creating biologically active compounds on base 1,3,4-thiadiazole.
I Sych, L Perekhoda, Z Іеremina
doaj