Results 61 to 70 of about 3,168 (197)

Utility of 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide in the synthesis of heterocyclic compounds with antimicrobial activity

BMC Chemistry, 2019
Background Pyrazolines show different biological activities. In recent years, interest in the chemistry of hydrazonoyl halides has been renewed. 1,3,4-Thiadiazoles are one of the most common heterocyclic pharmacophores with a wide range of biological ...
Abdou O. Abdelhamid, Ibrahim E. El Sayed, Yasser H. Zaki, Ahmed M. Hussein, Mangoud M. Mangoud, Mona A. Hosny   +5 more
doaj   +1 more source

Recent developments in the chemistry and enzyme inhibitory activity of fused thiazoles and thiadiazoles

Vietnam Journal of Chemistry, Volume 63, Issue 6, Page 872-882, December 2025.
Abstract The combination of cyclization reactions of thiadiazoles and benzothiazoles with Pd‐catalyzed cross‐coupling reactions provided a convenient synthesis of annulated, fluorinated and non‐fluorinated heterocycles, such as 1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐5‐ones, benzothiazolo[3,2‐a]pyridimidin‐4‐ones, benzothiazolo[2,3‐b]quinazolin‐12‐ones and ...
Peter Langer
wiley   +1 more source

Synthesis, spectroscopic and crystal structure analysis of a compound with pharmocophoric substituent: 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)- imidazo[2,1-b] [1,3,4]thiadiazole-5-carbaldehyde [PDF]

, 2007
Imidazo[2,1-b][1,3,4] thiadiazole derivatives are significant for their various pharmacological properties. This paper reports the synthesis and structure of one of them, 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5 ...
Girija, C.R., Hegde, V.S., Khazi, I.M., Kolavi, G.D., Noor Shahina Begum, ., Vasundhara, D.E.   +5 more
core   +1 more source

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors

ChemistryOpen, Volume 14, Issue 11, November 2025.
Novel benzimidazothiazole–thiazole hybrids are synthesized and evaluated for anticancer activity against HCT‐116 colon cancer cells. Compound 16b shows superior cytotoxicity over doxorubicin. Molecular docking confirms strong binding to 6MTU protein, and ADMET profiling indicates favorable pharmacokinetics and low toxicity.
Bader Huwaimel, Amr S. Abouzied, Magdi E. A. Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M. Gomha   +6 more
wiley   +1 more source

Interfering Transposable Elements: ISXoo15 Transposase as a First‐in‐Class Antibacterial Target Against Xanthomonas oryzae pv. oryzae

Molecular Plant Pathology, Volume 26, Issue 11, November 2025.
The study identifies the previously unknown transposase ISXoo15 as an antiphytobacterial target. By constructing mutant strains, this enzyme's essential role in regulating bacterial pathogenicity and virulence is revealed. ABSTRACT Current challenges in controlling phytopathogenic bacteria lie in widespread chemical resistance, biosafety concerns, and ...
Funeng Lu, Ting Liu, Tangbing Yang, Ziming Wang, Jianzhuan Li, Chunni Zhao, Huan Wu, Deyu Hu, Baoan Song   +8 more
wiley   +1 more source

Anti‐Corrosive Covalent Iodo‐Thiadiazole Catalyst Enables Aqueous Zn─S Batteries with High Coulombic Efficiency

Advanced Materials, Volume 37, Issue 43, October 29, 2025.
In aqueous Zn–S batteries, a covalently bonded iodo–thiadiazole redox mediator suppresses parasitic I3−‐mediated Zn corrosion and enhances Zn–S redox kinetics, enabling pouch cell with a high capacity of 1398 mAh g−1 after 120 cycles. This innovative catalyst design is a leap toward practical and grid‐scale aqueous Zn–S batteries. Abstract Aqueous zinc‐
Jiahao Liu, Yujie Chen, Han Wu, Chao Ye, Shi‐Zhang Qiao   +4 more
wiley   +1 more source

A Drug Delivery to Improve Prognosis of Traumatic Brain Injury Mice Through Mouse‐Derived Nerve Growth Factor Coated by a Nanoparticle

CNS Neuroscience &Therapeutics, Volume 31, Issue 10, October 2025.
This study is the first to demonstrate that mNGF, when nanocrystallized, crosses the BBB more effectively in TBI mice, subsequently aiding the repair and functional recovery of the nervous system post‐injury. ABSTRACT Objective The large molecular weight and limited permeability of mouse‐derived nerve growth factor (mNGF) across the blood–brain barrier
Ruichen Zhao, Shiying Dong, Di Wu, Yu Tian, Jiangyuan Yuan, Liang Mi, Chenrui Wu, Shiao Tong, Rongcai Jiang   +8 more
wiley   +1 more source

A Convenient route for the synthesis of antimicrobial 1, 3, 4- thiadiazole derivatives

Bibechana, 2012
  Thiosemicarbazide of 6-chloro-2- aminobenzothiazole on cyclization with different aromatic carboxylic acids in Phosphorus oxychloride provided the corresponding 2-aryl-5-(6’-chloro-1’,3’-benzothiazole-2-yl-amino)-1,3,4-thiadiazoles 4a-j. The compounds
AD Mishra
doaj   +3 more sources

Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives [PDF]

, 2011
Imidazo[2,1-b][1,3,4]thiadiazoles (4a-g) were synthesized from 3,4,5-trimethoxy benzoic acid and thiosemicarbazide. Reaction of 4 with Vilsmeier-Haack reagent yielded imidazo [2,1-b][1,3,4] thiadiazole–5-carbaldehyde derivatives (5a-g).
Alagawadi, Kallanagouda Ramappa, Alegaon, Shankar Gaddeppa   +1 more
core   +1 more source

Fibrous Pb(II)‐Based Coordination Polymer Operable as a Photocatalyst and Electrocatalyst for High‐Rate, Selective CO2‐to‐Formate Conversion

Advanced Functional Materials, Volume 35, Issue 28, July 10, 2025.
A coordination polymer [Pb(tadt)]n prepared by a microwave‐assisted solvothermal method selectively reduces CO2 into formate under visible light with a high apparent quantum yield of ≈25% at 400 nm. It can function as a pre‐catalyst, along with conductive Ketjen Black, to form an active PbCO3/Pb3(CO3)2(OH)2 mixture that exhibits a high Faradaic ...
Chomponoot Suppaso, Ryosuke Nakazato, Shoko Nakahata, Yoshinobu Kamakura, Fumitaka Ishiwari, Akinori Saeki, Daisuke Tanaka, Kazuhide Kamiya, Kazuhiko Maeda   +8 more
wiley   +1 more source