Results 91 to 100 of about 4,897,037 (304)

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Cellular uptake and fate of fibroin microspheres loaded with randomly fragmented DNA in 3T3 cells

International Journal of Nanomedicine, 2016
Jin Sil Lee, Won Hur Department of Bioengineering and Technology, Kangwon National University, Chuncheon, South Korea Abstract: Purified fibroin protein can be obtained in large quantities from silk fibers and processed to form microscopic particles as
Lee JS, Hur W
doaj  

The top 10 affected pathways in 3T3-A212P cells.

, 2013
The top 10 affected pathways in 3T3-A212P cells.
Kenneth Wee (387154), Wenjie Qiu (387153), Xuemei Lim (387156), George K. Radda (198986), Weiping Han (198991), Kosuke Takeda (387155), Shigeki Sugii (387157)   +6 more
core   +1 more source

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

A Recyclable and Biodegradable High‐Performance Piezoelectric Nanogenerator for Self‐Powered Biosensing and Assistive Human‐Machine Interaction

Advanced Science, EarlyView.
By exploiting multiscale hydrogen‐bonding interactions between HFPD and TOCNF, the composite simultaneously achieves a high piezoelectric coefficient (14.0 pC·N−1), outstanding flexibility (100 000 bending cycles), water‐assisted recyclability, excellent biodegradability, and sensitive wearable/implantable sensing for motion, speech, and Morse code ...
Tingshuai Luo, Tian Xiao, Luyu Zhang, Bailang Zhang, Shengchang Lu, He Xiao, Jianguo Li, Kai Liu, Chaoji Chen, Hui Wu   +9 more
wiley   +1 more source

Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells

Cellular & Molecular Biology Letters, 2019
Background Autologous cultivated oral mucosal epithelial transplantation (COMET) is an important treatment for limbal stem cell deficiency. However, peripheral corneal neovascularization after surgery hinders its application.
Chao-Ye Duan, Hua-Tao Xie, Xin-Yue Zhao, Wen-Han Xu, Ming-Chang Zhang   +4 more
doaj   +1 more source

Pioglitazone (Pio) partially rescues defective adipogenesis in 3T3-A212P cells.

, 2013
(A) 3T3-CON, 3T3-WT and 3T3-A212P cells were treated with the standard adipogenic cocktail (DMI) or DMI plus 1 µM Pio. The cells were stained with Oil Red O at day 8 and photographed under a microscope. Scale bars = 200, 100, 200 and 100 µm, respectively.
Kenneth Wee (387154), Wenjie Qiu (387153), Xuemei Lim (387156), George K. Radda (198986), Weiping Han (198991), Kosuke Takeda (387155), Shigeki Sugii (387157)   +6 more
core   +1 more source

Depletion of AFF4 in hMSCs and 3T3-L1 cells.

, 2022
(A, B) Western blot and RT-qPCR analysis of AFF4 expression 48 h after AFF4 knockdown in hMSCs. (C) CCK8 assay of hMSCs proliferation. n = 6. (D, E) Western blot and RT-qPCR analysis of AFF4 expression 48 h after Aff4 knockdown in 3T3-L1 cells.
Weimin Lin (2117626), Chong Chen (360710), Rui Liu (54031), Yuting Liu (270221), Xuelan Chen (9134204), Shuang Jiang (1443706), Bin Shao (460997), Yaqian Chen (1711576), Chenchen Zhou (1654087), Yuning Zhang (1290063), Qiwen Li (772694), Quan Yuan (83568)   +11 more
core   +1 more source