Results 101 to 110 of about 4,897,037 (304)

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

open access: yesAdvanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian   +14 more
wiley   +1 more source

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

open access: yesAdvanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu   +6 more
wiley   +1 more source

Kbtbd11 gene expression in adipose tissue increases in response to feeding and affects adipocyte differentiation

open access: yesJournal of Diabetes Investigation, 2019
Aims/Introduction The putative tumor suppressor gene, KBTBD11, might play a role in tumorigenesis, and is associated with cellular apoptosis and proliferation in colorectal cancer cells.
Kazuhisa Watanabe   +2 more
doaj   +1 more source

Lipids of whole cells and plasma membrane fractions from Balb/c3T3, SV3T3, and concanavalin A-selected revertant cells.

open access: yesJournal of Lipid Research, 1979
The lipid composition of Balb/c3T3, SV3T3, and the concanavalin A-selected SV3T3 revertant cells has been analyzed at the whole cell and plasma membrane levels.
S Ruggieri, R Roblin, P H Black
doaj   +1 more source

3T3/wt and 3T3/Rb−/− cells show differential response to redox imbalance-induced apoptosis.

open access: yes, 2014
(A) Ratios of fluorescence obtained at 400/480 nm excitation wavelengths in cells expressing Grx1-roGFP2 were measured in the presence or absence of 10 mM of NAC or 200 µM of H2O2 for 24 h. (B and C) Apoptosis was determined after 3T3/wt cells (B) or 3T3/
Binghui Li (531497)   +6 more
core   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

open access: yesAdvanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng   +16 more
wiley   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

open access: yesAdvanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu   +8 more
wiley   +1 more source

Redox state, not ROS, is corresponding to the transformation ability of 3T3 cells.

open access: yes, 2014
(A) Glutathione system was artificially modulated by NAC, over-expression of Gpx1 (glutathione peroxidase 1) or GSR (glutathione reductase). (B) Colony formation ability of 3T3/wt cells expressing Gpx1 or GSR and 3T3/Rb−/− cells expressing Gpx1 or GSR ...
Binghui Li (531497)   +6 more
core   +1 more source

Home - About - Disclaimer - Privacy