Results 171 to 180 of about 66,837 (297)

Scrotal Botulinum Toxin Exposure and Male Fertility: Mechanistic Insights and Clinical Evidence. [PDF]

Cureus
Azeem A, Sharma AC, Garchitorena JM, Boukind A, Omari IH, Nigro N.   +5 more
europepmc   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Enhanced Insecticidal Efficiency of Transgenic Bt Cotton Seed Following Application of Amino Acid Combinations. [PDF]

Plants (Basel)
Ji M, Abidallha EHMA, Zhang X, Chen Y, Chen D.   +4 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Sentinel monitoring for resistance to Bt toxins in European corn borer (Lepidoptera: Crambidae) in Canada. [PDF]

J Econ Entomol
Smith JL, Farhan Y, Wells J, Congdon C, Saguez J, Byker H, Gavloski J, Kelly J, Dively G.   +8 more
europepmc   +1 more source

Stress‐to‐Light Conversion in an Earth‐Abundant Oxide Semiconductor

Advanced Science, EarlyView.
Stress‐to‐light conversion in solids represents a unique photonic functionality, yet it has never been realized in a chemically simple and sustainable material. Here, we show that sustainable semiconductor ZnO exhibits strong near‐infrared (NIR) luminescence under elastic stress when defect‐engineered to stabilize the p‐type state.
Tomoki Uchiyama, Koki Otonari, Reona Omori, Guangfa Yang, Eiji Nishibori, Ying Chen, Xu‐Guang Zheng, Chao‐Nan Xu   +7 more
wiley   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Sustained efficacy of botulinum toxin in primary palmar hyperhidrosis: a systematic review of duration, quality of life, and satisfaction. [PDF]

Front Med (Lausanne)
Eze C, Munoz-Lara S, Whyte T, Jafferany M.   +3 more
europepmc   +1 more source

A double-edged sword: AB toxins as attack (cholera toxin) and defense (CCTX2) mechanisms

AB toxins are proteins often used by pathogens as an attack molecule. However, some organisms use them as a defense molecule, when threatened by a predator. This PhD thesis provides insights on the understanding of the molecular mechanism of two AB toxins, representing the two distinct roles of attack and defense.
openaire   +2 more sources

Reverse Weak Polarity‐Induced Ordered Layer Control for Enhanced Second‐Harmonic Generation in Ultraviolet Nonlinear Optical Crystals

Advanced Science, EarlyView.
Reverse Weak Polarity‐Induced Ordered Layer Control strategy, optimizing the design of layered structures, has been successfully designed. By leveraging inhomogeneous field of units to replace isotropic fields of metal cations, polar layers realize controllable layer stacking via a “layer→linker→layer” polarity transfer.
Lingli Wu, Chensheng Lin, Bing‐Xuan Li, Huixin Fan, Lingfei Lv, Shunda Yang, Tao Yan, Min Luo   +7 more
wiley   +1 more source