Results 181 to 190 of about 66,837 (297)

Diphtheria toxin-based efficient target-switchable anticancer drug

, 2018
Recombinant immunotoxins (RITs) have been extensively utilized in the field of targeted cancer therapy. RITs are composed of toxins derived from natural bacterial strains and antibodies for target specific killing of cancer cells.
Choi, Bonseo, Park, Seongguk, Bae, Yoonji, Kang, Sebyung   +3 more
core  

Time-Dependent Efficacy and Safety of Percutaneous Treatments for Lateral Epicondylitis: A Systematic Review and Network Meta-Analysis. [PDF]

J Pain Res
Xu Y, Lin W, Qi Z, Yan Z, Yan Q, Xu J, Wu L.   +6 more
europepmc   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Alternaria alternata leaf spot pathogens : genetics, evolutionary history and diagnostics [PDF]

The primary objective of this study was to characterise the Alternaria alternata species group. Particular focus was put on understanding the pathogens Alternaria mali and Alternaria gaisen, responsible for leaf spot diseases of apple and pear and of ...
Armitage, Andrew D.
core  

Investigation of Clostridium difficile antigen, toxin A+B and toxin genes in cases of hospital acquired diarrhea

International Journal of Infectious Diseases, 2014
S. Kescioglu, O. Coskun, O. Bedir, A. Karakas, C. Artuk, C.P. Eyigun   +5 more
doaj   +1 more source

Retraction: Dominant Negative Mutants of Bacillus thuringiensis Cry1Ab Toxin Function as Anti-Toxins: Demonstration of the Role of Oligomerization in Toxicity. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Interference of Large Clostridial Glucosyltransferases with the Endolysosomal Pathway: Toxin-Induced Imbalance of Early Endosomes, Functional Lysosomes and Autophagosomes. [PDF]

Toxins (Basel)
Langejürgen A, Schmidt G, Unsöld L, Tatge H, Oyson E, Gerhard R.   +5 more
europepmc   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

A host defense role for Fibrinogen by direct binding of Clostridium botulinum C2 toxin. [PDF]

Cell Mol Life Sci
Kistermann S, Heber S, Fischer S, Sichau J, Schmidt CQ, Mannes M, Huber-Lang M, Barth H.   +7 more
europepmc   +1 more source