Results 141 to 150 of about 40,738 (244)

Effect of ABCB1 SNP polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban in Chinese NVAF patients: a population pharmacokinetic-based study

Frontiers in Pharmacology
BackgroundThis study utilized a population pharmacokinetic (PPK) approach to assess the influence of ABCB1 genetic polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban.MethodsThe PPK model for rivaroxaban was developed using ...
Fei Wang, Ze Li, Youqi Huang, Qin Liu, Libin Zhao, Honghong Wang, Honghong Wang, Hongjin Gao, Mingyu Chen, Yuze Lin, Xingang Li, Min Chen   +11 more
doaj   +1 more source

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 237-256, May 2026.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

Endophytic Biostimulant Pyrroloquinoline Quinone Enhances Banana Growth and Primes Immunity Against Fusarium Wilt

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Pyrroloquinoline quinone (PQQ) is a redox cofactor derived from prokaryotes that participates in various biological processes involving dehydrogenase enzymes. Previous field trials identified a PQQ‐producing endophyte, Burkholderia seminalis 869T2, which enhances banana growth and reduces Fusarium wilt incidence from 24.5% to 3.4%.
Shih‐Hsun Walter Hung, Man‐Yun Yu, Chia‐Ho Liu, Tsai‐Ching Huang, Jian‐Hau Peng, Nai‐Yun Jang, Chih‐Horng Kuo, Yu‐Liang Yang, Ying‐Ning Ho, En‐Pei Isabel Chiang, Hau‐Hsuan Hwang, Chieh‐Chen Huang   +11 more
wiley   +1 more source

Studies on Genes Related to Copper Accumulation of the Fujian Oyster Crassostrea angulata [PDF]

, 2015
牡蛎是具有重要经济价值的海水养殖品种，在世界很多地区都有养殖。而我国牡蛎养殖产量居世界首位。同时，牡蛎对铜、锌等金属具有很强的富集能力，经常被用于指示河口污染情况。随着工业发展，近岸河口区遭受越来越严重的金属污染，铜就是其中非常有代表性的金属污染物。因此牡蛎对铜的超富集现象越来越被人们所关注。学者们发现牡蛎对铜富集存在非常大的个体差异，然而相关的研究却非常有限，特别是缺少分子机制的解析。对这一现象的深入研究不但可以探寻、丰富牡蛎铜富集相关机制，更可以为选育牡蛎不同金属富集能力品系提供理论依据 ...
史博
core  

ABCB1 Gene [PDF]

, 2020
openaire   +1 more source

ABCB1 2 Allele [PDF]

, 2020
openaire   +1 more source

ABCB1 wt Allele [PDF]

, 2020
openaire   +1 more source

Promoter hypomethylation drives ABCB1-mediated carfilzomib resistance in multiple myeloma. [PDF]

Clin Epigenetics
Han S, Haertle L, Munawar U, Truger M, Hainold AS, Lee CY, Kurian S, Verbruggen C, Nerreter S, Vogt C, Besant E, Rein N, Lehmann J, Köppel M, Tamamushi Y, Zhou X, Steinbrunn T, Haaf T, Küster B, Slaby O, Haferlach C, Einsele H, Rasche L, Waldschmidt J, Besse A, Driessen C, Besse L, Kortüm KM.   +27 more
europepmc   +1 more source

ABCB1 Polymorphisms Influence on Temozolomide Resistance and Overall Survival in Glioblastoma Patients: A Systematic Review of Clinical Evidence. [PDF]

J Cell Mol Med
De Luca F, Mannino D, Capra AP, Ciappina G, Donato M, Caruso G, Esposito E, Ardizzone A.   +7 more
europepmc   +1 more source