Results 131 to 140 of about 40,738 (244)

Cytotoxic Profiling of 3′,4′,5′‐Trimethoxychalcones Reveals Cell‐Line‐Dependent Cytotoxic Activity: An In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
A systematic evaluation of 3′,4′,5′‐trimethoxychalcones reveals potent yet strongly cell‐line‐dependent cytotoxic activity across multiple cancer models. Despite high potency, no universal structure–activity relationships emerge. Combined in vitro and in silico analyses indicate a multifactorial, context‐dependent mode of action, underscoring the need ...
Aleksandar Y. Mehandzhiyski, Abdessamad Beraich, Zhivko Velkov, Maya Zaharieva, Spiro Konstantinov, Daniela Batovska   +5 more
wiley   +1 more source

Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population [PDF]

Caspian Journal of Internal Medicine
Background: Allelic variants of genes encoding enzymes of the esterase system (CES1) and P-glycoprotein (ABCB1) can change the metabolism and pharmacokinetics of dabigatran.
Ayan Abdrakhmanov, Elena Zholdybayeva, Aizhana Shaimerdinova, Gulmira Kulmambetova, Svetlana Abildinova, Rustam Albayev, Gulnara Tuyakova, Elena Rib, Zhanasyl Suleimen, Zhanar Abdrakhmanova, Makhabbat Bekbossynova   +10 more
doaj  

Transcriptome analysis of ABCB1, ABCG2 and the BCL2/BAX ratio in refractory and relapsed canine lymphomas under treatment and rescue protocol

Acta Veterinaria, 2018
The main problems that cause unresponsiveness to an anti-neoplastic drug are the overexpression of drug resistant and anti-apoptotic proteins in tumor cells.
Sirivisoot Sirintra, Teewasutrakul Patharakrit, Rungsipipat Anudep, Tangkawattana Sirikachorn, Techangamsuwan Somporn   +4 more
doaj   +1 more source

Clinical Significance of Biomarkers in Oropharyngeal Squamous Cell Carcinoma: Recurrence Prediction and Treatment Response

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Oropharyngeal squamous cell carcinoma (OPSCC) accounts for a substantial proportion of head and neck cancers, with a rising incidence largely driven by human papillomavirus (HPV) infection. Despite advances in multimodal treatment, disease recurrence remains common and limits long‐term survival, highlighting the need for reliable ...
Yunxia Chen, Wenyu Zhang, Xiang Gao, Kongling Xing, Yijing Ren, Jinyu Hu, Zhihao Xie, Ping Zhou   +7 more
wiley   +1 more source

Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used

Infection and Drug Resistance, 2022
Irma Olarte Carrillo,1 Christian Omar Ramos Peñafiel,2 Iveth Mendoza Salas,2 Rafael Cerón Maldonado,1 Anel Irais García Laguna,1 Adrián De la Cruz Rosas,1 Carlos Martinez Murrillo,2 Adolfo Martinez Tovar1 1Laboratorio de Biología Molecular, Servicio de ...
Olarte Carrillo I, Ramos Peñafiel CO, Mendoza Salas I, Cerón Maldonado R, García Laguna AI, De la Cruz Rosas A, Martinez Murrillo C, Martinez Tovar A   +7 more
doaj  

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1331-1339, May 2026.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors

Communications Chemistry
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resistance, yet current ABCB1 inhibitors have ...
Javier Yu Peng Koh, Yoko Itahana, Alexander Krah, Habib Mostafa, Mingmin Ong, Sahana Iwamura, Dona Mariya Vincent, Sabhashina Radha Krishnan, Weiying Ye, Pierre Wing Chi Yim, Tushar M. Khopade, Kunihiko Chen, Pui San Kong, Lin-Fa Wang, Roderick W. Bates, Yasuhisa Kimura, Rajesh Viswanathan, Peter J. Bond, Koji Itahana   +18 more
doaj   +1 more source

Dissecting minimal residual disease dynamics to improve outcome prediction in mantle cell lymphoma: Data from the Fondazione Italiana Linfomi (FIL)‐MCL0208 clinical trial

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Recent clinical trials have underscored the value of repeated minimal residual disease (MRD) measurements as a highly sensitive method for detecting subclinical disease and enabling dynamic risk stratification in hematologic malignancies. Despite its clinical potential, the complex and heterogeneous nature of MRD kinetics presents significant ...
Francesca Cordero, Simone Ferrero, Simone Pernice, Elisa Genuardi, Daniela Volpatto, Roberta Sirovich, Aurora Maria Civita, Andrea Evangelista, Simone Ragaini, Alice Di Rocco, Alessandro Re, Vittorio Stefoni, Federica Cavallo, Carola Boccomini, Monica Balzarotti, Vittorio Ruggero Zilioli, Maria Gomes da Silva, Luca Arcaini, Melania Celli, Gian Maria Zaccaria, Dora Tortarolo, Marco Beccuti, Eva Hoster, Christiane Pott, Elizabeth Macintyre, Olivier Hermine, Martin Dreyling, Marco Ladetto   +27 more
wiley   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Pharmacogenetics of Mycophenolic Acid in Patients of African Descent: Underrepresentation of African Data

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Mycophenolic acid (MPA) is a potent antiproliferative immunosuppressive agent used to prevent organ transplant rejection and to treat various immune‐mediated diseases. MPA is the active metabolite formed from the biotransformation of the prodrugs mycophenolate mofetil (MMF) or enteric‐coated mycophenolate sodium (EC‐MPS).
Migael Mouton, Bianca Davidson, Jessica Taylor, Marc Blockman, Erika Jones, Robert Freercks, Khuthala Mnika, Collet Dandara   +7 more
wiley   +1 more source