Results 121 to 130 of about 40,738 (244)
ABCB1: is there a role in the drug treatment of Parkinson’s disease? [PDF]
Expert Opinion on Drug Metabolism & Toxicology, 2017 Efflux proteins are a member of the ATP-binding cassette (ABC) transporter superfamily, which groups various importer and exporter membrane proteins [1].
openaire +2 more sources
Scientific Reports, 2017 Multidrug resistance (MDR) attenuates the chemotherapy efficacy and increases the probability of cancer recurrence. The accelerated drug efflux mediated by ATP-binding cassette (ABC) transporters is one of the major MDR mechanisms.
Yi-Jun Wang +11 more
doaj +1 more source
Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review [PDF]
, 2009 Over-expression of P-glycoprotein (P-gp), the encoded product of the ATP-binding cassette (ABC), sub-family B, member 1 (ABCB1/MDR1) gene, plays an important role in mediating multidrug resistance to antiepileptic drugs (AEDs) in about 30% of patients ...
Haerian BS, +6 more
core
Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management
Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz +3 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.Simvastatin synergizes with cisplatin in cisplatin‐resistant cervical cancer cells through suppression of the caveolin‐1‐mediated PI3K/AKT signaling axis. ABSTRACT Cervical cancer treatment is often hindered by the emergence of cisplatin (DDP) resistance. Increasing evidence has indicated that statins possess anti‐tumor and chemosensitization potential
Yujia Zhou +7 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Open MedicineThis study investigated the relationship between ATP-binding cassette sub-family B member 1 (ABCB1) and OLIG2 single nucleotide polymorphism (SNP) and neurological injury severity and outcome in cerebral infarction (CI).
Liang ChaoYing +5 more
doaj +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang +8 more
wiley +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Exploring Resistance to ETS Targeting Agents in Diffuse Large B‐Cell Lymphoma
Cancer Medicine, Volume 15, Issue 5, May 2026.This study provides the first systematic characterization of resistance to ETS inhibition in diffuse large B‐cell lymphoma (DLBCL). Using TK216‐resistant models, we reveal heterogeneous escape mechanisms, including MDR1 upregulation, transcriptional reprogramming, and cytoskeletal remodeling, each associated with distinct mutational signatures ...
Filippo Spriano +9 more
wiley +1 more source