Results 121 to 130 of about 29,397 (197)

Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 82-96).Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ...
Swart, Marelize
core  

Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Polyphenol‐rich plant extracts provide natural immunomodulatory protection for oral health through complementary antioxidant, antibacterial, and anti‐inflammatory actions. Their potential to reduce harmful microbial activity and inflammation highlights the promise of dietary polyphenols as a natural strategy for maintaining oral health and preventing ...
Deepa Subramanian, Divya Krishnamoorthi, Gowtham Kannan, Benedict Mathews Paul   +3 more
wiley   +1 more source

α‐Glucosidase and Acetylcholinesterase (AChE) Inhibitory Activities, Larvicidal Potential and GC–MS Analysis of Endlicheria paniculata: A Combined Experimental and Molecular Docking Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
This study investigates the essential oil composition of E. paniculata wood, bark, and leaves by GC–MS. Biological evaluations of the leaf essential oil reveal promising larvicidal potential against Aedes aegypti and in vitro inhibitory activities against α‐glucosidase and acetylcholinesterase (AChE), supported by molecular docking simulations ...
Jenifer Priscila de Araujo, Luiz Everson Da Silva, Wanderlei do Amaral, Michele Debiasi Alberton, Ana Helena Loos Moritz, Fernando Cesar Martins Betim, Deise Prehs Montrucchio, Marilis Dallarmi Miguel, Josiane de Fátima Gaspari Dias, Hélcio Silva Dos Santos, Emmanuel Silva Marinho, Márcia Machado Marinho, Jacilene Silva, Obdulio Gomes Miguel   +13 more
wiley   +1 more source

Molecular and Immune Features of Metastatic Prostate Cancer in Hispanic and Non‐Hispanic American Men

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Prostate cancer (PCa) is the most common solid tumor in American men, with persistent ethnic disparities, particularly among Hispanic American (HA) men. The tumor microenvironment (TME) and tumor genomics may contribute to disease progression but remain undercharacterized in HA populations.
Alejandro Recio‐Boiles, Sachin Kumar Deshmukh, Cassandra Jean Everly, Sharon Wu, Ricardo J. Estrada‐Mendizabal, Elisabeth Heath, Rana R. McKay, Cynthia Miranti, Ken Batai, Benjamin R. Lee, Juan Chipollini   +10 more
wiley   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 871-889, October 2026.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source

Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice

Environmental Health and Preventive Medicine
Background: Perfluorooctanoic acid (PFOA) is one of the major per- and polyfluoroalkyl substances. The role of ATP-binding cassette (ABC) transporters in PFOA toxicokinetics is unknown.
Kazuyoshi Furukawa, Kahori Okamoto-Matsuda, Kouji H. Harada, Mutsuko Minata, Toshiaki Hitomi, Hatasu Kobayashi, Akio Koizumi   +6 more
doaj   +1 more source

CRISPR‐Cas9 in Cancer Therapy: Overcoming Delivery Barriers and Off‐Target Effects for Clinical Translation

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims CRISPR‐Cas9 gene editing has transformed molecular biology and has great potential as a therapeutic tool for cancer and many other human diseases. This perspective review elaborates on the recent advances in CRISPR‐Cas9 technology and its application as an innovative cancer treatment. Additionally, this perspective outlines
Md Mohiuddin, Md Al Mamun Ahsan
wiley   +1 more source

Mechanistic Prediction of Maternal, Fetal, and Amniotic Fluid Betamethasone Concentrations to Support Dosing Optimization in Pregnancy

The Journal of Clinical Pharmacology, Volume 66, Issue 10, October 2026.
Abstract Respiratory distress syndrome (RDS) remains a major cause of neonatal mortality following premature birth. Antenatal betamethasone is the standard of care to accelerate fetal lung maturation and improve neonatal outcomes; however, current dosing recommendations assume uniform maternal and fetal exposure across pregnancies. Gestational age (GA)‐
Alaa Mahdi, Khaled Abduljalil, Fernanda de Lima Moreira, Hiral Raju Mehta, Jhohann Richard de Lima Benzi, Alessandra Cristina Marcolin, Stephan Schmidt, Natalia V. de Moraes   +7 more
wiley   +1 more source

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure [PDF]

, 2009
The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of ...
Sager, Georg, Sylte, Ingebrigt, Ravna, Aina W.   +2 more
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