Results 101 to 110 of about 29,397 (197)

Investigation of the Function and Regulation of ABC Transporters [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorATP-Binding-Cassette (ABC) transporters are primary active pumps that typically ...
Akkaya, Begum Gokcen
core   +1 more source

microRNA‐145‐5p regulates P‐glycoprotein and breast cancer resistance protein in primary human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye, Enrrico Bloise, Nikola Ivanovski, Lubna Nadeem, Christopher Casciaro, Stephen G. Matthews   +5 more
wiley   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Association of CYP3A4/5, ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen

, 2013
Insee Sensorn,1 Ekaphop Sirachainan,2 Montri Chamnanphon,3 Ekawat Pasomsub,4 Narumol Trachu,5 Porntip Supavilai,1 Chonlaphat Sukasem,3 Darawan Pinthong11Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand; 2Division of ...
Pasomsub E, Pinthong D, Sirachainan E, Trachu N, Sukasem C, Chamnanphol M, Supavilai P, Sensorn I   +7 more
core  

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Transcriptome analysis of ABCB1, ABCG2 and the BCL2/BAX ratio in refractory and relapsed canine lymphomas under treatment and rescue protocol

Acta Veterinaria, 2018
The main problems that cause unresponsiveness to an anti-neoplastic drug are the overexpression of drug resistant and anti-apoptotic proteins in tumor cells.
Sirivisoot Sirintra, Teewasutrakul Patharakrit, Rungsipipat Anudep, Tangkawattana Sirikachorn, Techangamsuwan Somporn   +4 more
doaj   +1 more source

Chemotherapy resistance and risk stratification in gestational trophoblastic neoplasia: A systematic review and network meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 11, Page 2158-2172, November 2026.
Higher pretreatment β‐hCG, greater tumor burden, higher FIGO stage/score, and choriocarcinoma were associated with higher chemoresistance risk in gestational trophoblastic neoplasia. In exploratory network analyses, etoposide‐containing regimens showed lower predicted chemoresistance.
Ying‐Ying Xue, Xin‐Yue Yang, Fang‐Yu Chen, Hui‐Ting Yang, Chao Zhang, Jin‐Zhu Yan, Shi‐Shi Wu, Long Wang   +7 more
wiley   +1 more source

ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development

, 2015
Arabidopsis abcb1 abcb19 double mutants defective in the auxin transporters ABCB1/PGP1 and ABCB19/PGP19 are altered in stamen elongation, anther dehiscence and pollen maturation.
NAPOLI, NADIA, COSTANTINO, Paolo, CECCHETTI, VALENTINA, FATTORINI, LAURA, ALTAMURA, Maria Maddalena, BRUNETTI, PATRIZIA, CARDARELLI, Maura, Brunetti P, Fattorini L, Altamura MM, Costantino P, Napoli N, Cecchetti V, Cardarelli M   +13 more
core   +1 more source

Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction

Open Medicine
This study investigated the relationship between ATP-binding cassette sub-family B member 1 (ABCB1) and OLIG2 single nucleotide polymorphism (SNP) and neurological injury severity and outcome in cerebral infarction (CI).
Liang ChaoYing, Huang CuiYan, Nong ZhenRu, Li SongLiang, Lin MinShi, Qin ZuYe   +5 more
doaj   +1 more source

ФАРМАКОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ТЕРАПИИ ТРОМБОЗА УШКА ЛЕВОГО ПРЕДСЕРДИЯ: РЕЗИСТЕНТНОСТЬ К ЛЕЧЕНИЮ ПРЯМЫМИ ПЕРОРАЛЬНЫМИ АНТИКОАГУЛЯНТАМИ У ПАЦИЕНТОВ С ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta
Актуальность. Фибрилляция предсердий (ФП) является самым распространенным нарушением ритма сердца, которое ассоциировано с повышенным риском тромбоэмболических осложнений.
О. В. Будревич, В. А. Снежицкий   +1 more
doaj   +1 more source