Results 101 to 110 of about 21,197 (211)
International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg +4 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Natural and synthetic protoflavonoids offer potent anticancer properties, but their chemical space remains largely unexplored. This study details the synthesis of eleven p‐hydroxydienone derivatives from chalcone precursors. We evaluated their antiproliferative effects across four human gynecological cancer cell lines.
Tímea Gonda +7 more
wiley +1 more source
Cancer Innovation, Volume 5, Issue 4, August 2026.Antiangiogenic‐based regimens demonstrated superior efficacy compared to chemotherapy alone in heavily pretreated MBC patients, with manageable AEs. ABSTRACT Background The prognosis for metastatic breast cancer (MBC) remains poor, and treatment options are limited for patients with heavily pretreated disease. Although antiangiogenic agents may provide
Yuanyi Wang +6 more
wiley +1 more source
Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors
Communications ChemistryChemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resistance, yet current ABCB1 inhibitors have ...
Javier Yu Peng Koh +18 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Patient‐derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR‐based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function.
Julianne du Plessis, Aadilah Omar
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 387-393, August 2026.5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists are used to treat nausea and vomiting and in the prevention of chemotherapy‐induced, radiation‐induced, and postoperative nausea and vomiting. Most of the 5‐HT3 receptor antagonists (i.e., ondansetron, tropisetron, dolasetron, palonosetron, and ramosetron) are metabolized by CYP2D6, but the extent
Claire Moore +16 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 8, August 2026.Flow chart of RCH to improve TGT‐induced nephrotoxicity. ABSTRACT Researches on Tripterygium glycosides tablets (TGT) often overlook renal toxicity from prolonged use. Rubus chingii Hu (RCH) is beneficial to kidney health and has an unclear role in reducing nephrotoxicity.
Cong Zhang +3 more
wiley +1 more source
Tamoxifen Therapy Is Associated With Altered Intestinal P‐Glycoprotein Activity In Vivo
The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.Abstract Preclinical studies suggest that tamoxifen (TAM) may interact with the efflux transporter P‐glycoprotein (P‐gp); however, its effect on intestinal P‐gp activity in vivo remains poorly characterized. This study evaluated intestinal P‐gp activity in women receiving tamoxifen therapy using fexofenadine (FEXO) as a probe substrate.
Álef Machado Gomes Pego +9 more
wiley +1 more source
Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance
MedComm, Volume 7, Issue 8, August 2026.The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar +12 more
wiley +1 more source
Uptake and Transport of Monotropein and Monotropein Esters in a Caco‐2/HT29‐MTX‐E12 Co‐Culture Model
Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.Monotropein and its naturally occurring ester derivatives (monotropein‐10‐coumarate and monotropein‐10‐cinnamate) from Gaultheria spp. berries exhibit limited intestinal permeability in a validated Caco‐2:HT29‐MTX‐E12 co‐culture model. Absorption occurs predominantly via passive diffusion, with partial SGLT1‐ and OATP‐mediated uptake contribution for ...
Christian Zielinski +7 more
wiley +1 more source