Results 91 to 100 of about 29,397 (197)

RETRACTED ARTICLE: Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Scientific Reports, 2017
Multidrug resistance (MDR) attenuates the chemotherapy efficacy and increases the probability of cancer recurrence. The accelerated drug efflux mediated by ATP-binding cassette (ABC) transporters is one of the major MDR mechanisms.
Yi-Jun Wang, Bhargav A. Patel, Nagaraju Anreddy, Yun-Kai Zhang, Guan-Nan Zhang, Saeed Alqahtani, Satyakam Singh, Suneet Shukla, Amal Kaddoumi, Suresh V. Ambudkar, Tanaji T. Talele, Zhe-Sheng Chen   +11 more
doaj   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

ABCB1 haplotype and OPRM1 118A > G genotype interaction in methadone maintenance treatment pharmacogenetics

, 2012
Daniel T Barratt1, Janet K Coller1, Richard Hallinan2, Andrew Byrne2, Jason M White1, David JR Foster3, Andrew A Somogyi1,41Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia; 2The Byrne Surgery ...
Coller JK, Hallinan R, White JM, Barratt DT, Foster DJR, Somogyi AA, Byrne A   +6 more
core  

Estudo da associação de genes e proteínas de resistência a múltiplos fármacos (abcb1/ABCB1, abcc1/ABCC1 e lrp/LRP) com marcadores moleculares em pacientes portadores de leucemias agudas [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.Menos de 45% dos portadores de leucemias agudas (LAs) sobrevivem cinco anos após o diagnóstico. O insucesso
Moraes, Ana Carolina Rabello de
core  

Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell

, 2018
ATP-binding cassette (ABC) transporters, which are concerned with the efflux of anticancer drugs from cancer cells, have a pivotal role in multidrug resistance (MDR).
Norihiko Sugisawa, Suresh V. Ambudkar (223101), Michiaki Unno (518981), Junken Aoki, Kosuke Ohsawa (1973299), Shinobu Ohnuma (223071), Hidetoshi Tokuyama, Kyoko Sugiyama (5622722), Kyoko Sugiyama, Katsuyoshi Kudoh (5622725), Hirofumi Ueda, Masaharu Ishida, Kosuke Ohsawa, Takeshi Naitoh, Norihiko Sugisawa (5622716), Michiaki Unno, Masaharu Ishida (126995), Katsuyoshi Kudoh, Hirofumi Ueda (1748680), Hidetoshi Tokuyama (1748674), Takayuki Doi (1400446), Suresh V. Ambudkar, Shinobu Ohnuma, Junken Aoki (58497), Kuniyuki Kano (741224), Takayuki Doi, Takeshi Naitoh (518978), Megumi Murakami, Megumi Murakami (5622719), Kuniyuki Kano   +29 more
core   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation [PDF]

, 2012
Polar transport of the plant hormone auxin is controlled by PIN- and ABCB/PGP-efflux catalysts. PIN polarity is regulated by the AGC protein kinase, PINOID (PID), while ABCB activity was shown to be dependent on interaction with the FKBP42, TWISTED ...
Endler, A., Wang, Bangjun, Pollmann, Stephan, Weiwad, M., Oehring, Sophie C, Weiwad, Matthias, Nanni, Paolo, Schulz, Alexander, Henrichs, S., Zhu, J., Oehring, S., Geisler, M., Henrichs, Sina, Pollmann, S., Zhu, Jinsheng, Bailly, Aurélien, Linnert, M., Schulz, A., Fukao, Y., Nanni, P., Charrier, L., Charrier, Laurence, Geisler, Markus, Bailly, A., Oehring, Sophie C., Wang, B., Linnert, Miriam, Mancuso, S., Mancuso, Stefano, Fukao, Yoichiro, Endler, Anne, Geisler M, Linnert M, Wang B, Schulz A, Nanni P, Mancuso S, Oehring SC, Charrier L, Bailly A, Pollmann S, Weiwad M, Fukao Y, Zhu J, Henrichs S, Endler A   +45 more
core   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Super analgesia of intrathecal morphine may be related to ABCB1 (MDR1) gene polymorphism

, 2018
Wangjun Qin,1,* Botao Liu,2,* Ang Deng,1 Ying Liu,1 Xianglin Zhang,1 Lei Zhang1 1Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China; 2Department of Pain Management, China-Japan Friendship Hospital, Beijing, China *These authors ...
Liu Y, Liu BT, Deng A, Zhang L, Zhang XL, Qin WJ   +5 more
core  

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source