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ФАРМАКОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ТЕРАПИИ ТРОМБОЗА УШКА ЛЕВОГО ПРЕДСЕРДИЯ: РЕЗИСТЕНТНОСТЬ К ЛЕЧЕНИЮ ПРЯМЫМИ ПЕРОРАЛЬНЫМИ АНТИКОАГУЛЯНТАМИ У ПАЦИЕНТОВ С ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta
Актуальность. Фибрилляция предсердий (ФП) является самым распространенным нарушением ритма сердца, которое ассоциировано с повышенным риском тромбоэмболических осложнений.
О. В. Будревич, В. А. Снежицкий   +1 more
doaj   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

Transcriptome analysis of ABCB1, ABCG2 and the BCL2/BAX ratio in refractory and relapsed canine lymphomas under treatment and rescue protocol

Acta Veterinaria, 2018
The main problems that cause unresponsiveness to an anti-neoplastic drug are the overexpression of drug resistant and anti-apoptotic proteins in tumor cells.
Sirivisoot Sirintra, Teewasutrakul Patharakrit, Rungsipipat Anudep, Tangkawattana Sirikachorn, Techangamsuwan Somporn   +4 more
doaj   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used

Infection and Drug Resistance, 2022
Irma Olarte Carrillo,1 Christian Omar Ramos Peñafiel,2 Iveth Mendoza Salas,2 Rafael Cerón Maldonado,1 Anel Irais García Laguna,1 Adrián De la Cruz Rosas,1 Carlos Martinez Murrillo,2 Adolfo Martinez Tovar1 1Laboratorio de Biología Molecular, Servicio de ...
Olarte Carrillo I, Ramos Peñafiel CO, Mendoza Salas I, Cerón Maldonado R, García Laguna AI, De la Cruz Rosas A, Martinez Murrillo C, Martinez Tovar A   +7 more
doaj  

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population [PDF]

Caspian Journal of Internal Medicine
Background: Allelic variants of genes encoding enzymes of the esterase system (CES1) and P-glycoprotein (ABCB1) can change the metabolism and pharmacokinetics of dabigatran.
Ayan Abdrakhmanov, Elena Zholdybayeva, Aizhana Shaimerdinova, Gulmira Kulmambetova, Svetlana Abildinova, Rustam Albayev, Gulnara Tuyakova, Elena Rib, Zhanasyl Suleimen, Zhanar Abdrakhmanova, Makhabbat Bekbossynova   +10 more
doaj  

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Umbralisib antagonizes multidrug resistance in ABCB1-overexpressing cancer cells

Frontiers in Oncology
IntroductionABCB1-mediated multidrug resistance (MDR) reduces the intracellular accumulation of anticancer drugs and limits chemotherapy efficacy. This study investigated whether umbralisib, a dual PI3Kδ/CK1ϵ inhibitor, could reverse ABCB1-mediated MDR ...
Letao Bo, Bohan Zhang, Xuan-Yu Chen, Xuanming Mao, Xuanming Mao, Luke Zhong, Meizi Tan, Mingyu Cui, Mingyu Cui, Harsh Patel, John N. D. Wurpel, Zhe-Sheng Chen   +11 more
doaj   +1 more source