Results 71 to 80 of about 29,397 (197)

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

BLAST results for TRINITY_DN90881_c0_g1_i10.p1 with ABCB1 orthologs.

, 2023
BLAST results for TRINITY_DN90881_c0_g1_i10.p1 with ABCB1 orthologs.
Alejandro Sanchez-Flores (207232), Jairo A. Cerón S. (16985547), Alejandra Bravo (322909), Pablo Emiliano Cantón (8262417), Luisa-Fernanda Velásquez C. (16985544), Mario Soberón (322907)   +5 more
core   +1 more source

CLOPIDOGREL PHARMACOGENETICS

Рациональная фармакотерапия в кардиологии, 2016
Platelets play an important role in the pathogenesis of atherosclerosis. They are involved in atherosclerosis progression and thrombotic complications. That is why antiplatelet therapy is a necessary element of these complications prevention in patients ...
A. N. Meshkov
doaj   +1 more source

Factors Associated With Long‐Term Survivors With Epidermal Growth Factor Receptor Positive Non‐Small Cell Lung Cancer Treated With First or Second‐Generation Tyrosine Kinase Inhibitors: A Canadian Multi‐Center Cohort

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In a multi‐center Canadian cohort of 577 patients with advanced epidermal growth factor receptor‐mutated non‐small cell lung cancer treated with first/second‐generation TKIs, Asian ancestry and female sex predicted longer survival, while the L858R mutation predicted shorter survival.
Heather Halperin, Amanda J. W. Gibson, Ali Hussein, Mike Sung, Pascale Tomasini, Michelle Dean, Jennifer H. Law, Cheryl Ho, Vishal Navani, Natasha B. Leighl, Desiree Hao   +10 more
wiley   +1 more source

ABCB1 is critical for SALL4-induced drug resistance.

, 2015
(A) Western blotting showed that ectopic overexpression of SALL4 upregulated ABCB1 protein expression in Ishikawa cells and knockdown of SALL4 in AN3CA cells downregulated ABCB1 expression.
Huali Xu (800184), Xiaoming Yang (113295), Xiaowei Xi (579191), Jing Zhang (23775), Chi Fang (800183), Lei Liu (5074)   +5 more
core   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Case-control association study of ABCB1 gene and major depressive disorder in a local Chinese Han population

, 2015
Wei-Wei Xie,1,2* Lin Zhang,1* Ren-Rong Wu,1 Yan Yu,3 Jing-Ping Zhao,1 Le-Hua Li1 1Mental Health Institute of the Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province,
Li LH, Zhao JP, Zhang L, Xie WW, Wu RR, Yu Y   +5 more
core  

Is Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? – A Case Report

Pharmacogenomics and Personalized Medicine, 2022
Chiara Jeiziner,1 Samuel S Allemann,1 Kurt E Hersberger,1 Henriette E Meyer zu Schwabedissen2 1Pharmaceutical Care Research Group, Department Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 2Biopharmacy, Department Pharmaceutical ...
Jeiziner C, Allemann SS, Hersberger KE, Meyer zu Schwabedissen HE   +3 more
doaj  

Preliminary Comparison of Competitive Efflux and Historical Transwell Assays for Assessing Canine P‐Glycoprotein Substrate Status of Eleven Drugs Representing Ten Different Drug Classes

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Because P‐glycoprotein (P‐gp) influences the disposition of substrate drugs, regulatory agencies recommend ascertaining the P‐gp substrate status of active pharmaceutical ingredients (API's) intended for humans. Transwell‐based assays using P‐gp‐overexpressing human cell lines are routinely used to predict the API's P‐gp substrate status ...
K. L. Mealey, N. S. Burke
wiley   +1 more source

Impact of ABCB1 Allelic Variants on QTc Interval Prolongation

, 2011
Purpose: Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several blood–tissue barriers (i.e., blood–brain and blood–nerve), its participation in a putative blood–heart barrier has been poorly explored.
David Liewehr, Douglas K. Price, David Venzon, Xiaohong Chen, Erin R. Gardner, Laura Miller-DeGraff, Ryan Franke, William D. Figg, James A. Clark, Seth M. Steinberg, Steven R. Kleeberger, Susan E. Bates, Richard L. Piekarz, Douglas R. Rosing, Tristan M. Sissung, Sukyung Woo, Alex Sparreboom, Reuben Howden, Christopher Cabell   +18 more
core   +1 more source