Results 111 to 120 of about 21,197 (211)

Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice

Environmental Health and Preventive Medicine
Background: Perfluorooctanoic acid (PFOA) is one of the major per- and polyfluoroalkyl substances. The role of ATP-binding cassette (ABC) transporters in PFOA toxicokinetics is unknown.
Kazuyoshi Furukawa, Kahori Okamoto-Matsuda, Kouji H. Harada, Mutsuko Minata, Toshiaki Hitomi, Hatasu Kobayashi, Akio Koizumi   +6 more
doaj   +1 more source

Extrapolating Vincristine‐Induced Peripheral Neuropathy From Caucasian to Kenyan Populations: Impact of Type I and Type II Selection Bias

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Vincristine is a cornerstone of pediatric chemotherapy, but its use is limited by vincristine‐induced peripheral neuropathy (VIPN). Paradoxically, African children tolerate higher vincristine doses with minimal neurotoxicity, raising questions about the pharmacological mechanisms and model generalizability across populations. In this study, we
Maddalena Centanni, Mirjam Esther van de Velde, Alwin D. R. Huitema, Gertjan L. Kaspers, Mats O. Karlsson, Lena E. Friberg   +5 more
wiley   +1 more source

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

British Journal of Pharmacology, Volume 183, Issue 16, Page 4761-4777, August 2026.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli   +10 more
wiley   +1 more source

ABCB1 Gene [PDF]

, 2020
openaire   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, Volume 183, Issue 16, Page 4735-4760, August 2026.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

ABCB1 2 Allele [PDF]

, 2020
openaire   +1 more source

ABCB1 wt Allele [PDF]

, 2020
openaire   +1 more source

The association of ABCB1, CYP2C19 and CYP2C9 combined activity with clopidogrel resistance in patients with recurrent ischemic stroke. [PDF]

Pharmacogenomics J
Deiman B, Hermans M, de Rijk M, Bras A, Scharnhorst V.   +4 more
europepmc   +1 more source

Association of <i>ABCB1</i> Genetic Variants with Epilepsy Susceptibility in Jordanian Cohort. [PDF]

Neurol Int
Abduljabbar R, Yousef AM, Eid Tamimi D, Z Abdullah S, Liu Z.   +4 more
europepmc   +1 more source

Pharmacogenetic variants in pharmacokinetic and pharmacodynamic pathways and clinical factors associated with bleeding risk in Thai patients receiving rivaroxaban: a case-control study. [PDF]

Ther Adv Drug Saf
Yodsurang V, Wattanathum K, Srimatimanon T, Pitinanon K, Ranti A, Siripattarachai P, Hirunpatrawong P, Rungpradubvong V, Sakamoto S, Sujarit AS.   +9 more
europepmc   +1 more source