Single-nucleotide polymorphisms of donor <i>CYP3A5</i> and recipient <i>ABCB1</i> affect tacrolimus intrapatient variability in living donor liver transplantation: a retrospective cohort study. [PDF]
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Targeting the MEK/ERK Pathway to Suppress P-Glycoprotein and Reverse Carfilzomib Resistance in Multiple Myeloma. [PDF]
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Functional and Transcriptional Disruption of Hepatic ABC Transporters by Environmentally Relevant Short-Chain Per- and Polyfluoroalkyl Substances (PFAS). [PDF]
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Association of <i>ABCB1</i> and <i>MTHFR</i> genetic polymorphisms with rheumatoid arthritis susceptibility in a Chinese population. [PDF]
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AbstractEuphorbia factor L1 (EFL1) belongs to diterpenoids of genus Euphorbia. In this article, its reversal activity against ABCB1‐mediated MDR in KBv200 and MCF‐7/adr cells was reported. However, EFL1 did not alter the sensitivity of KB and MCF‐7 cells to chemotherapeutic agents. Meanwhile, EFL1 significantly increased accumulation of doxorubicin and
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ABCB1 in children's brain tumours
Biochemical Society Transactions, 2015Tumours of the central nervous system are the most common solid tumour, accounting for a quarter of the 1500 cases of childhood cancer diagnosed each year in the U.K. They are the most common cause of cancer-related death in children. Treatment consists of surgery followed by adjuvant chemotherapy and/or radiotherapy.
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