Results 31 to 40 of about 40,232 (213)

ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1

Frontiers in Bioscience-Landmark, 2022
Background: One of the major concerns of cancer therapy is the emergence of multidrug resistance (MDR). The MDR-associated ATP-binding cassette sub-family B member 1 (ABCB1) transporter is established to mediate resistance against numerous anticancer ...
Zhuoxun Wu, Yuqi Yang, Zining Lei, Silpa Narayanan, Jingquan Wang, Qiuxu Teng, Megumi Murakami, Suresh V. Ambudkar, Fengfeng Ping, Zhesheng Chen   +9 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Validation of a simple genotyping panel assay for pharmacogenomics of taxane-based therapy: preliminary results [PDF]

World Cancer Research Journal, 2023
Objective: Several strategies for preventing toxicity and resistance to taxane-based chemotherapy have been investigated so far. Lately, findings on the genetic variants associated with neutropenia and neuropathy (N&N) toxicity have been reported ...
A. Vitale, L. Di Francia, D. Costagliola, M. Mignano, A. Luise, M. Di Paolo, S. Pugliese, V. De Lucia, E. Varriale, R. Di Francia   +9 more
doaj   +1 more source

The ABCB1 transporter gene and antidepressant response [PDF]

F1000 Biology Reports, 2009
P-glycoprotein, encoded by the ABCB1 gene, may modulate the brain concentration of several antidepressants. Functional genetic variation is thought to exist in this gene, and here we review several studies that have attempted to associate this variation with clinical response to antidepressant treatment.
Peters, Eric J, Reus, Victor, Hamilton, Steven P   +2 more
openaire   +4 more sources

Erdafitinib Antagonizes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Frontiers in Oncology, 2020
ABCB1 overexpression is known to contribute to multidrug resistance (MDR) in cancers. Therefore, it is critical to find effective drugs to target ABCB1 and overcome MDR.
Weiguo Feng, Weiguo Feng, Meng Zhang, Meng Zhang, Zhuo-Xun Wu, Jing-Quan Wang, Xing-Duo Dong, Yuqi Yang, Qiu-Xu Teng, Xuan-Yu Chen, Xuan-Yu Chen, Qingbin Cui, Dong-Hua Yang   +12 more
doaj   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source

The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects

Pharmacogenomics and Personalized Medicine, 2021
Yue Liu,1,* Chenguang Yang,2,* Wenyuan Qi,1 Zuowei Pei,2 Wei Xue,1 Huolan Zhu,2 Min Dong,2 Ying Guo,2 Duanduan Cong,1 Fang Wang2 1Clinical Trial Center, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science ...
Liu Y, Yang C, Qi W, Pei Z, Xue W, Zhu H, Dong M, Guo Y, Cong D, Wang F   +9 more
doaj  

Bruton’s Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Frontiers in Cell and Developmental Biology, 2020
Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1) remains one of the most vital factors leading to multidrug resistance (MDR). It is important to enhance the effect and bioavailability of chemotherapeutic drugs that are substrates of ...
Xing-Duo Dong, Meng Zhang, Meng Zhang, Xiubin Ma, Jing-Quan Wang, Zi-Ning Lei, Qiu-Xu Teng, Yi-Dong Li, Lusheng Lin, Weiguo Feng, Weiguo Feng, Zhe-Sheng Chen   +11 more
doaj   +1 more source

Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia

Pharmaceutical Biology, 2018
Context: Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia.
Javad Mottaghipisheh, Márta Nové, Gabriella Spengler, Norbert Kúsz, Judit Hohmann, Dezső Csupor   +5 more
doaj   +1 more source

Interpretation of results obtained using real-time fluorescence PCR based on multiplex PCR fragment analysis for ABCB1 tri-allele

Sichuan jingshen weisheng, 2022
ObjectiveTo resolve the problems related to the abnormal interpretations of real-time fluorescence polymerase chain reaction （PCR） results for tri-allele， to formulate the interpretation methods of real-time fluorescence PCR by referring to multiplex PCR
Zhang Yan, Meng Zhuocheng, Xing Huan, Cui Xiaohua, Yang Liu, Zheng Xuan, Dai Zunxiao   +6 more
doaj   +1 more source