Results 111 to 120 of about 26,096 (220)
, 2013 (A) K562/ABCG2 cells, overexpressing ABCG2, were plated with mitoxantrone and topotecan at increasing concentrations in the absence and presence of quizartinib at 0.1, 0.5 and 1 µM and the established ABCG2 transport inhibitor fumitremorgin C at 10 µM ...
Jasjeet Bhullar (445431) +6 more
core +1 more source
Microbial Biotechnology, Volume 19, Issue 11, November 2026.Reprogramming native cryptic plasmids of Escherichia coli Nissle 1917 enabled antibiotic‐selection‐free and oxygen‐adaptive urate degradation. The engineered strain reduced uric acid levels and alleviated hyperuricemia‐associated renal and inflammatory abnormalities in mice, supporting endogenous plasmid engineering as a strategy for live ...
Yuan Chi +5 more
wiley +1 more source
The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRP
, 2012 ABCG2/BCRP is an ATP-binding cassette transporter that extrudes compounds from cells in the intestine, liver, kidney, and other organs, such as the mammary gland, affecting pharmacokinetics and milk secretion of antibiotics, anticancer drugs, and other ...
Egido, Estefanía +6 more
core +1 more source
Quizartinib increases uptake of fluoroquinolones in cells expressing ABCG2.
, 2013 K562/ABCG2 (A) and 8226/MR20 (B) cells, overexpressing ABCG2, were incubated with ciprofloxacin at a fixed concentration (25µg/ml) in the absence and presence of quizartinib at a range of concentrations for 30 minutes, and with the ABCG2 transport ...
Jasjeet Bhullar (445431) +6 more
core +1 more source
Frontiers in Pharmacology, 2018 The ATP-binding cassette transporter ABCG2 (BCRP and MXR) is involved in the absorption, distribution, and elimination of numerous drugs. Thus, drugs that are able to reduce the activity of ABCG2, e.g., antihypertensive AT1 receptor antagonists (ARBs ...
Anne Ripperger +4 more
doaj +1 more source
In vitro identification of decreased function phenotype ABCG2 variants
, 2023 Reduced activity of efflux transporter ABCG2, caused e.g., by inhibition or decreased function genetic variants, can increase drug absorption and plasma levels.
Seppo Auriola +11 more
core +1 more source
iScienceSummary: Breast cancer resistance protein (ABCG2) significantly contributes to decreased sensitivity of tumor cells to chemotherapy. While ABCG2 inhibitors exist, multidrug resistance remains unresolved due to limited specificity, toxicity, and ...
Yanhong Pan +10 more
doaj +1 more source
ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches
, 2017 MC Cleophas,1,2 LA Joosten,1–3 LK Stamp,4 N Dalbeth,5 OM Woodward,6 Tony R Merriman7 1Department of Internal Medicine, 2Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; 3Department of ...
Stamp LK +5 more
core
Growth and senescence of IGR39 ABCG2+ and ABCG2− human melanoma cells.
, 2012 Panel A shows the fraction of positive cells for ABCG2+ and ABCG2− cells. In both cases, senescence increases rapidly after 90 days; the fraction reaches higher values for ABCG2− cells.
Caterina A. M. La Porta (187294) +2 more
core +1 more source
The International Journal of Biological Markers, 2013 Purpose We retrospectively analyzed ABCG2 expression levels in patients with metastatic colorectal cancer (CRC) to investigate the interaction between ABCG2 expression and the tumor response to oxaliplatin and 5-fluorouracil (FOLFOX). Methods Forty-three
Pei-Ching Lin +7 more
doaj +1 more source