Results 121 to 130 of about 26,096 (220)
Detection of the PTEN/PI3K/Akt signal pathway, ABCG2 and SP in leukemia cells.
, 2014 (a) BCR-ABL transcript expression was upregulated in all drug-resistant cells, whereas higher ABCG2 transcript was only detected in K562/ABCG2 and K562/IMR cells. (b) Western blot analysis revealed decreased PTEN protein but increased p-Akt expression in
Fang-Fang Huang (119739) +7 more
core +1 more source
Oncotarget, 2014 ABCG2 is a potential biomarker causing multidrug resistance (MDR) in Non-Small Cell Lung Cancer (NSCLC). We conducted this study to investigate whether Icotinib, a small-molecule inhibitor of EGFR tyrosine kinase, could interact with ABCG2 transporter in NSCLC. Our results showed that Icotinib reversed ABCG2-mediated MDR by antagonizing the drug efflux
De-Shen, Wang +13 more
openaire +3 more sources
ABCG2+ valvular cells deposit more calcified matrix than ABCG2- cells in osteogenic conditions.
, 2013 Sorted ABCG2+ and ABCG2- valvular cells were grown to confluence and re-plated in osteogenic media for 8 days. (A) Brightfield images of cells cultured in control conditions or osteogenic conditions were taken at day 8.
Balaji Sridhar (435979) +3 more
core +1 more source
Frontiers in Pharmacology, 2018 The main characteristic of tumor cell resistance is multidrug resistance (MDR). MDR is the principle cause of the decline in clinical efficacy of chemotherapeutic drugs. There are several mechanisms that could cause MDR.
Wei Zhang +11 more
doaj +1 more source
New Analogs of Tariquidar: Synthesis, Characterization and Evaluation of their Inhibitory Activity against Breast Cancer Resistance Protein (ABCG2) [PDF]
, 2016 El primer capítulo describe los moduladores específicos de la ABCG2 reportados hasta la fecha, La visión global puede facilitar el diseño racional de nuevos moduladores potentes y seguros.
Peña Solórzano, Diana Catherine
core
, 2013 K562/ABCG2 (A) and 8226/MR20 (B) cells overexpressing ABCG2 were incubated with the ABCG2 substrate chemotherapy drugs mitoxantrone and topotecan at fixed concentrations in the absence and presence of quizartinib at a range of concentrations for 48 hours.
Jasjeet Bhullar (445431) +6 more
core +1 more source
A humán ABCG2 multidrog transzporter működésének vizsgálata = Investigation of the mechanism of action of the human ABCG2 multidrug transporter [PDF]
, 2009 A humán ABCG2 egy plazma membrán glikoprotein, amely a szervezet méregtelenítésében játszik szerepet, ezen kívül ellenállóvá teheti a rákos sejteket bizonyos gyógyszerekkel szemben. Az ABCG2 az őssejtek egyik jellegzetes fehérjéje.
Laczka, Csilla
core +1 more source
THE ROLE OF ABCG2 IN DRUG ACTIVE TRANSPORT IN MILK [PDF]
, 2010 Drug active transport into milk is a major concern for breastfeeding mothers and healthcare providers. Studies from the literature indicated that breast cancer resistance protein (ABCG2) plays an important role in drug transfer into milk.
Wang, Lipeng
core
Transport activity and expression of double mutated ABCG2-transporter
, 2021 ABCG2-proteiini on ATP:n avulla substraatteja solukalvon yli kuljettava puolitransportteri. Sitä tavataan muun muassa suolistossa, maksassa, munuaisissa, veri-aivoesteessä ja istukassa, missä toimiessaan se vaikuttaa merkittävästi useiden ...
Vieraankivi, Marika
core
Detection of ABCG2 expression level by specific monoclonal antibodies.
, 2012 The Figure shows the correlation of the ABCG2 expression level detected by the 5D3 monoclonal antibody in the fixed whole cells, recognizing the ABCG2 protein on an extracellular epitope, and the weighed average of BXP21 and BXP34 antibodies (BXP34/3 ...
György Várady (120120) +8 more
core +1 more source