Results 91 to 100 of about 113,995,962 (231)

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Analysis of the drug target of the anti-tuberculosis compound OCT313: phosphotransacetylase is a potential drug target for anti-mycobacterial agents

mSphere
Tuberculosis (TB) is one of the most common infectious diseases caused by bacteria worldwide. The increasing prevalence of multidrug-resistant TB (MDR-TB) and latent TB infection (LTBI) has intensified the global TB burden.
Takemasa Takii, Tomohiro Hasegawa, Saotomo Itoh, Shinji Maeda, Takayuki Wada, Yasuhiro Horita, Akihito Nishiyama, Sohkichi Matsumoto, Naoya Ohara, Aoi Kimishima, Yukihiro Asami, Shigeaki Hida, Kikuo Onozaki   +12 more
doaj   +1 more source

Light‐Driven Butyrate Production by a Probiotic Clostridium tyrobutyricum Enabled by a Cell‐Semiconductor Hybrid Interface

Food Chemistry International, EarlyView.
This schematic illustrates a light‐driven biohybrid system where CdS nanoparticles, mineralized on the probiotic Clostridium tyrobutyricum, inject photoelectrons to elevate intracellular NADH. This boosts the flux through key NADH‐dependent enzymes (GapA, Hbd, and Bcd), reprogramming metabolism to enhance butyrate yield by 33.2% and selectivity to 95.7%
Qianru Zhao, Zhihan Yang, Bowen Shen, Ling Jiang   +3 more
wiley   +1 more source

Acetyl Coenzyme A Synthesis from Unnatural Methylated Corrinoids:  Requirement for “Base-Off” Coordination at Cobalt

, 2016
Acetyl Coenzyme A Synthesis from Unnatural Methylated Corrinoids:  Requirement for “Base-Off” Coordination at ...
Stephen W. Ragsdale (1264635), Javier Seravalli (1264638), Kenneth L. Brown (2168224)   +2 more
core   +1 more source

Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity

Research
Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes.
Sanjeeb Shrestha, Yu-Bin Lee, Hoyul Lee, Yeon-Kyung Choi, Bo-Yoon Park, Mi-Jin Kim, Young-Jin Youn, Sun-Hwa Kim, Soo-Jung Jung, Dong-Keun Song, Hee Kyung Jin, Jae-Sung Bae, In-Kyu Lee, Jae-Han Jeon, Chang-Won Hong   +14 more
doaj   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Multi-Method Quantification of Acetyl-Coenzyme A and Further Acyl-Coenzyme A Species in Normal and Ischemic Rat Liver. [PDF]

Int J Mol Sci, 2023
Tokarska-Schlattner M, Zeaiter N, Cunin V, Attia S, Meunier C, Kay L, Achouri A, Hiriart-Bryant E, Couturier K, Tellier C, El Harras A, Elena-Herrmann B, Khochbin S, Le Gouellec A, Schlattner U.   +14 more
europepmc   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk. [PDF]

Immunohorizons, 2022
Greenwood DL, Ramsey HE, Nguyen PTT, Patterson AR, Voss K, Bader JE, Sugiura A, Bacigalupa ZA, Schaefer S, Ye X, Dahunsi DO, Madden MZ, Wellen KE, Savona MR, Ferrell PB, Rathmell JC.   +15 more
europepmc   +1 more source

S as a measure of biological relevance for the N-acetyltransferase Gna1 bound either to coenzyme A (CoA) (pdb: 4ag7; 1.55 Å) or to both CoA and N-acetyl-D-glucosamine-6-phosphate (GlcNAc-6P) (pdb: 4ag9; 1.76 Å).

, 2019
S as a measure of biological relevance for the N-acetyltransferase Gna1 bound either to coenzyme A (CoA) (pdb: 4ag7; 1.55 Å) or to both CoA and N-acetyl-D-glucosamine-6-phosphate (GlcNAc-6P) (pdb: 4ag9; 1.76 Å).
Andrew F. Neuwald (9828), Stephen F. Altschul (245577)   +1 more
core   +1 more source