Results 11 to 20 of about 2,693 (199)

The mammalian longevity associated acetylome [PDF]

Nature Communications
Despite extensive studies at the genomic, transcriptomic and metabolomic levels, the underlying mechanisms regulating longevity are incompletely understood. Post-translational protein acetylation is suggested to regulate aspects of longevity.
S. Feldman-Trabelsi, N. Touitou, R. Nagar, Z. Schwartz, A. Michelson, S. Shaki, M. Y. Avivi, B. Lerrer, S. Snir, H. Y. Cohen   +9 more
doaj   +4 more sources

Co‐Translational Deposition of N6‐Acetyl‐L‐Lysine in Nascent Proteins Contributes to the Acetylome in Mammalian Cells [PDF]

Advanced Science
N6‐acetyl‐L‐lysine residue is abundant in dietary protein but little is known about its potential influences on the diet‐consumers. Herein, it is reported that Lysyl‐tRNA synthetase (KARS) mediates co‐translational deposition of diet‐derived N6‐acetyl‐L ...
Dingyuan Guo, Nan Li, Xiaoyan Zhang, Runxin Zhou, Jie He, Xiao‐Ping Ding, Weixing Yu, Fuqiang Tong, Sibi Yin, Yu Wang, Xin Xu, Long Wang, Mingzhu Fan, Shan Feng, Ke Liu, Ke Tang, Zhuqing Ouyang, Yusong R Guo, Yugang Wang   +18 more
doaj   +3 more sources

Understanding the adipose tissue acetylome in obesity and insulin resistance [PDF]

Translational Research, 2022
Obesity is a widely prevalent pathology with a high exponential growth worldwide. Altered lipid accumulation by adipose tissue is one of the main causes of obesity and exploring lipid homeostasis in this tissue may represent a source for the identifica ...
Malagon, Maria M, López-Alcalá, J., Díaz-Ruiz, Alberto, Malagón, María M., Tinahones, Francisco J, Guzmán Ruiz, R., Tinahones, Francisco J., Moral, Sandra Diaz Del, Navarro-Ruiz, Maria Del Carmen, Nieto Calonge, Andrea, Tercero-Alcazar, Carmen, Guzman-Ruiz, Rocio, Lopez-Alcala, Jaime, Díaz del Moral, Sandra, Tercero-Alcázar, C., Nieto-Calonge, Andrea, Navarro-Ruiz, Carmen, López-Miranda, José, Sandra Díaz Del Moral, Carmen Tercero-Alcázar, Andrea Nieto-Calonge, María M. Malagón, Alberto Díaz-Ruiz, Francisco J. Tinahones, José López-Miranda, Maria del Carmen Navarro-Ruiz, Jaime López-Alcalá, Rocío Guzmán-Ruiz   +27 more
core   +6 more sources

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome [PDF]

Cell Reports, 2017
Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is
Carles Cantó, Galindo, Antonio Nunez, Atger, F., Naef, Felix, Ratajczak, Joanna, Frédéric Gachon, Wang, J., Da Silva, L., Laetitia Da Silva, Jingkui Wang, Martin, Francois-Pierre, Montoliu, I., Núñez Galindo, A., Felix Naef, Martin, F.P., Joanna Ratajczak, Daniel Mauvoisin, Antonio Núñez Galindo, Cantó, C., Mauvoisin, Daniel, Kussmann, Martin, Martin Kussmann, Collino, Sebastiano, Atger, Florian, Sebastiano Collino, Collino, S., Eva Martin, Ivan Montoliu, Canto, Carles, Da Silva, Laetitia, Dayon, L., Gachon, F., Loïc Dayon, Kussmann, M., Naef, F., Dayon, Loic, Francois-Pierre Martin, Martin, E., Gachon, Frederic, Florian Atger, Wang, Jingkui, Ratajczak, J., Mauvoisin, D., Montoliu, Ivan, Martin, Eva, Kussmann M, Wang J, Martin E, Núñez Galindo, Antonio, Cantó C, Gachon F, Ratajczak J, Martin FP, Atger F, Dayon L, Mauvoisin D, Da Silva L, Montoliu I, Collino S, Naef F, Núñez Galindo A   +60 more
core   +8 more sources

Acetylation‐like H2BK109Q attenuates acute brain injury and preserves axon‐myelin integrity after intracerebral hemorrhage [PDF]

CNS Neurosci Ther
After intracerebral hemorrhage, reduced pan‐H2B acetylation is linked to acute brain injury and axon–myelin damage. The acetylation‐mimetic H2BK109Q substitution attenuates injury and preserves axon–myelin integrity. Regional Galc knockdown diminishes this protection, identifying GALC as a primary contributing effector. ABSTRACT Aims Axon–myelin damage
Jin S, Yang M, Meng J, Han Z, Rastegar‐Kashkooli Y, Lu P, Wang J, Wang J, Wu H.   +8 more
europepmc   +2 more sources

Decoding ferroptosis via integrated multi-omics analyses in rice blast. [PDF]

Imeta
The rice‐Magnaporthe oryzae pathosystem is presented as a host‐pathogen ferroptosis model. Multi‐omics insights connect ferroptosis to several cellular processes, such as iron homeostasis, reactive oxygen species (ROS)/redox imbalance, and polyunsaturated fatty acid‐containing phospholipid (PUFA‐PL) peroxidation, under multiple regulators in rice and M.
Liang Z, Shen Q, Nguyen NK, Long R, Ma Y, Liu Q, Naqvi NI, Jwa NS, Deng YZ.   +8 more
europepmc   +2 more sources

High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

eLife, 2022
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect
Morten Hostrup, Anders Krogh Lemminger, Ben Stocks, Alba Gonzalez-Franquesa, Jeppe Kjærgaard Larsen, Julia Prats Quesada, Martin Thomassen, Brian Tate Weinert, Jens Bangsbo, Atul Shahaji Deshmukh   +9 more
doaj   +2 more sources

Histone Acetylome-wide Association Study of Autism Spectrum Disorder [PDF]

Cell, 2016
SummaryThe association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation ...
Prabhakar, S., Hajan, H. S., Geschwind, D. H., Geschwind, Daniel, H., Ramasamy, R., Mill, Jonathan, Poschmann, J., Prabhakar, Shyam, del Rosario, Ricardo Cruz-Herrera, Wong, C. C. Y., Parikshak, Neelroop, N, Belgard, T Grant, Elanggovan, B., Geschwind, Daniel H, Parikshak, N. N., Ramasamy, Ramalakshmi, Elanggovan, Bavani, Cruz-Herrera del Rosario, R., Kumar, Vibhor, Sun, Wenjie, Sun, W., Parikshak, Neelroop N, Kumar, V., Belgard, T. G., Wong, Chloe Chung Yi, Geschwind, Daniel H., Poschmann, Jérémie, Cruz-Herrera del Rosario, Ricardo, Hajan, Hajira Shreen, Parikshak, Neelroop N., Belgard, T. Grant   +30 more
core   +6 more sources

Stearoyl-CoA Desaturase-1 Drives Tumor Growth by Interacting With Histone Deacetylase-2 and Deacetylating Nucleophosmin-1. [PDF]

MedComm (2020)
Hypoxia induces SCD1 and PLIN2 to drive lipid droplet‐dependent metabolic adaptation in cancer cells. PLIN2 supports survival under stress, whereas SCD1 promotes proliferation upon reoxygenation and remodels the acetylome via HDAC2‐mediated NPM1 deacetylation and destabilization.
Wery C, Montero-Ruiz L, Bonneil E, Farran M, Jehay R, Garfia QH, Fettweis G, Blacher S, Pottier C, Cobraiville G, Boumahd Y, Peulen O, Noël A, Dequiedt F, Fillet M, Sounni NE.   +15 more
europepmc   +2 more sources

Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues

Nature Communications, 2023
Patient samples are often available in limited amounts, restricting the number of possible omics analyses. Here the authors present MONTE, a workflow that enables serial HLA-I and HLA-II immunopeptidome, ubiquitylome, proteome, phosphoproteome, and ...
Jennifer G. Abelin, Erik J. Bergstrom, Keith D. Rivera, Hannah B. Taylor, Susan Klaeger, Charles Xu, Eva K. Verzani, C. Jackson White, Hilina B. Woldemichael, Maya Virshup, Meagan E. Olive, Myranda Maynard, Stephanie A. Vartany, Joseph D. Allen, Kshiti Phulphagar, M. Harry Kane, Suzanna Rachimi, D. R. Mani, Michael A. Gillette, Shankha Satpathy, Karl R. Clauser, Namrata D. Udeshi, Steven A. Carr   +22 more
doaj   +2 more sources