Results 61 to 70 of about 2,693 (199)

Monoclonal Antibody Cocktail as an Enrichment Tool for Acetylome Analysis [PDF]

Analytical Chemistry, 2011
The availability and robustness of methods to analyze phosphorylated proteins has greatly expanded our knowledge of phosphorylation based cell signaling. A key ingredient to the success of these studies is the ability to enrich phosphopeptides using antibodies or other chemical approaches.
Patrick G, Shaw, Raghothama, Chaerkady, Zhen, Zhang, Nancy E, Davidson, Akhilesh, Pandey   +4 more
openaire   +2 more sources

DataSheet1_Suberoylanilide Hydroxamic Acid (SAHA) Treatment Reveals Crosstalk Among Proteome, Phosphoproteome, and Acetylome in Nasopharyngeal Carcinoma Cells.DOCX

, 2022
Suberoylanilide hydroxamic acid (SAHA), a famous histone deacetylase (HDAC) inhibitor, has been utilized in clinical treatment for cutaneous T-cell lymphoma.
Yongheng Chen (627094), Huichao Huang (9692036), Miaolong Lu (8083400), Maoyu Li (72071), Ying Fu (173963), Zhuchu Chen (72074), Yankun Duan (627093), Ye Zhang (132223)   +7 more
core   +1 more source

Simultaneous Quantification of the Acetylome and Succinylome by ‘One‐Pot’ Affinity Enrichment [PDF]

PROTEOMICS, 2018
AbstractProtein posttranslational modifications (PTMs) are of increasing interest in biomedical research, yet studies rarely examine more than one PTM. One barrier to multi‐PTM studies is the time cost for both sample preparation and data acquisition, which scale linearly with the number of modifications.
Basisty, Nathan, Meyer, Jesse, Wei, Lei, Gibson, Bradford, Schilling, Birgit   +4 more
openaire   +4 more sources

Table_4_Genome-Wide Analyses of Proteome and Acetylome in Zymomonas mobilis Under N2-Fixing Condition.XLSX

, 2021
Zymomonas mobilis, a promising candidate for industrial biofuel production, is capable of nitrogen fixation naturally without hindering ethanol production. However, little is known about the regulation of nitrogen fixation in Z. mobilis.
Sawar Khan (6324086), Yuhuan Huang (11532565), Mingxiong He (653738), Bo Wu (16141), Ayesha Nisar (6324083), Mao Chen (92698), Xiangxu Gongye (11532562)   +6 more
core   +1 more source

The acetyltransferase SCO0988 controls positively specialized metabolism and morphological differentiation in the model strains Streptomyces coelicolor and Streptomyces lividans

Frontiers in Microbiology
Streptomycetes are well-known antibiotic producers possessing in their genomes numerous silent biosynthetic pathways that might direct the biosynthesis of novel bio-active specialized metabolites.
Yunwen Bi, Hao An, Zhewei Chi, Zhongheng Xu, Yuan Deng, Yuxian Ren, Rui Wang, Xinyi Lu, Jia Guo, Ren Hu, Marie-Joelle Virolle, Delin Xu   +11 more
doaj   +1 more source

Large-scale identification of lysine acetylated proteins in vegetative hyphae of the rice blast fungus

Scientific Reports, 2017
Lysine acetylation is a major post-translational modification that plays important regulatory roles in diverse biological processes to perform various cellular functions in both eukaryotes and prokaryotes.
Xiaomei Sun, Zhigang Li, Hang Liu, Jun Yang, Wenxing Liang, You-Liang Peng, Jinguang Huang   +6 more
doaj   +1 more source

KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis

Med Research, EarlyView.
The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao, Guohui Yu, Shikui Wu, Zhiyang Zhang, Keke Wang, Yingxin Xiong, Chao Sun, Haobo Cui, Yuxing Wang, Ziheng Wang, Huiru Zhang, Huiqin Xue, Shibing Guo   +12 more
wiley   +1 more source

Table_2_Genome-Wide Analyses of Proteome and Acetylome in Zymomonas mobilis Under N2-Fixing Condition.XLSX

, 2021
Zymomonas mobilis, a promising candidate for industrial biofuel production, is capable of nitrogen fixation naturally without hindering ethanol production. However, little is known about the regulation of nitrogen fixation in Z. mobilis.
Sawar Khan (6324086), Yuhuan Huang (11532565), Mingxiong He (653738), Bo Wu (16141), Ayesha Nisar (6324083), Mao Chen (92698), Xiangxu Gongye (11532562)   +6 more
core   +1 more source

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

Molecular & Cellular Proteomics, 2017
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino acid side-chains, leading to the possibility that aspirin-mediated lysine acetylation could explain some ...
Tatham, Michael H., Cole, Christian, Scullian, Paul, Wilkie, Ross, Westwood, Nicholas J., Stark, Lesley A., Hay, Ronald T.   +6 more
openaire   +5 more sources

Integrated multi‐omics analysis of post‐translational modifications in head and neck squamous cell carcinoma: elucidating x‐ray and carbon ion irradiation effects

Precision Radiation Oncology, EarlyView.
This study underscores the critical role of PTMs in mediating cellular responses to X‐ray and Carbon ion irradiation radiotherapy in HNSCC. The integration of multi‐omics data provides insights into the molecular mechanisms underlying radiation‐induced changes, offering valuable clues for improving therapeutic outcomes and advancing precision medicine ...
Fan‐Tong Xia, Zhi‐Yun Liao, Si‐Qi Cai, Li‐Rong Zhou, Meng‐Qi Yang, Xin Zhang, Dan Li, Huan Zhang, Yun‐Chang Liu, Jie‐Ying Yang, Jia Jiang, Yi‐Hong Hu, Jiang‐Dong Sui, Ying Wang   +13 more
wiley   +1 more source