Results 101 to 110 of about 3,455 (202)
Development of a circulating tumour cell culture model from head and neck squamous cell carcinoma
VIEW, Volume 6, Issue 6, December 2025.Nectin‐4 is frequently overexpressed in various solid tumors; however, conventional photosensitizers for photodynamic therapy (PDT) often exhibit poor aqueous solubility and nonspecific accumulation in healthy tissues, leading to off‐target phototoxicity. To overcome these limitations, we developed a Nectin‐4‐targeted nanobody‐chlorin e6 conjugate (NPC)
Xiaomin Huang +14 more
wiley +1 more source
The Aging Landscape by scRNAseq of Mesenchymal Lineage Cells in Mouse Bone
Aging Cell, Volume 24, Issue 12, December 2025.scRNA‐seq analysis reveals age‐related changes in bone mesenchymal cells in male and female mice. Moreover, the comparison of aging and autophagy deficiency in bone mesenchymal cells shows overlap and suggests that age‐related decline in autophagy contributes to skeletal aging.
Melda Onal +12 more
wiley +1 more source
CXCR4/ACKR3 Phosphorylation and Recruitment of Interacting Proteins: Key Mechanisms Regulating Their Functional Status [PDF]
Molecular Pharmacology, 2019 The C-X-C motif chemokine receptor type 4 (CXCR4) and the atypical chemokine receptor 3 (ACKR3/CXCR7) are class A G protein-coupled receptors (GPCRs). Accumulating evidence indicates that GPCR subcellular localization, trafficking, transduction properties, and ultimately their pathophysiological functions are regulated by both interacting proteins and ...
Fumagalli, Amos +8 more
openaire +7 more sources
PLoS ONE, 2018 We observed in PRESTO-Tango β-arrestin recruitment assays that the α1-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological behavior.
Xianlong Gao +5 more
doaj +1 more source
Blood, 2021 Platelet ACKR3/CXCR7 surface expression is enhanced and influences prognosis in coronary artery disease-(CAD) patients, who exhibit a distinct atherothrombotic platelet lipidome.
M. Cebo +18 more
semanticscholar +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Emerging roles of atypical chemokine receptor 3 (ACKR3) in normal development and physiology [PDF]
, 2018 The discovery that atypical chemokine receptors (ACKRs) can initiate alternative signaling pathways rather than classical G-protein coupled receptor (GPCR) signaling has changed the paradigm of chemokine receptors and their roles in modulating ...
Caron, K.M., Mackie, D.I., Quinn, K.E.
core +2 more sources
PROTEOMICS, Volume 25, Issue 21-22, Page 25-40, November 2025.ABSTRACT Mass spectrometry (MS) offers robust, label‐free approaches for characterizing ligand–protein interactions through two main strategies: affinity‐based and stability‐based assays. However, their application to membrane proteins (MPs)—a major class of drug targets—has been limited by challenges such as structural complexity, low native ...
Jonathon C. Lambos +3 more
wiley +1 more source
bioRxivThe canonical paradigm of GPCR signaling recognizes G proteins and β-arrestins as the two primary transducers that promote GPCR signaling. Recent evidence suggests the atypical chemokine receptor 3 (ACKR3) does not couple to G proteins, and β-arrestins ...
Chloe N. Hicks +8 more
semanticscholar +1 more source
Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. [PDF]
, 2019 The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population.
Alex, Linda +22 more
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