Results 1 to 10 of about 287,702 (305)
Actin cytoskeleton in angiogenesis. [PDF]
Biol Open, 2022 ABSTRACTActin, one of the most abundant intracellular proteins in mammalian cells, is a critical regulator of cell shape and polarity, migration, cell division, and transcriptional response. Angiogenesis, or the formation of new blood vessels in the body is a well-coordinated multi-step process.
Yadunandanan Nair N +5 more
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Regulation of the Actin Cytoskeleton in Podocytes [PDF]
Cells, 2020 Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents filtration of large proteins and macromolecules into the urine. Podocyte function is dependent on actin cytoskeleton regulation within the foot processes, structures that link podocytes to the glomerular basement membrane.
Judith Blaine, James Dylewski
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The yeast actin cytoskeleton [PDF]
FEMS Microbiology Reviews, 2014 The actin cytoskeleton is a complex network of dynamic polymers, which plays an important role in various fundamental cellular processes, including maintenance of cell shape, polarity, cell division, cell migration, endocytosis, vesicular trafficking, and mechanosensation. Precise spatiotemporal assembly and disassembly of actin structures is regulated
Mithilesh Mishra +2 more
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Phagocytosis and the actin cytoskeleton [PDF]
Journal of Cell Science, 2001 ABSTRACT The process of engulfing a foreign particle – phagocytosis – is of fundamental importance for a wide diversity of organisms. From simple unicellular organisms that use phagocytosis to obtain their next meal, to complex metazoans in which phagocytic cells represent an essential branch of the immune system, evolution has armed ...
Laura M. Machesky, Robin C. May
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Dynamic reorganization of the actin cytoskeleton [PDF]
F1000Research, 2015 Cellular processes, including morphogenesis, polarization, and motility, rely on a variety of actin-based structures. Although the biochemical composition and filament organization of these structures are different, they often emerge from a common origin. This is possible because the actin structures are highly dynamic. Indeed, they assemble, grow, and
Manuel Théry +5 more
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Ultrastructure of the actin cytoskeleton [PDF]
Current Opinion in Cell Biology, 2018 The actin cytoskeleton is the primary force-generating machinery in the cell, which can produce pushing (protrusive) forces using energy of actin polymerization and pulling (contractile) forces via sliding of bipolar filaments of myosin II along actin filaments, as well as perform other key functions.
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Actin cytoskeleton: Putting a CAP on actin polymerization [PDF]
Current Biology, 2000 Two recent studies have identified a Drosophila homolog of cyclase-associated protein (CAP) as a developmentally important negative regulator of actin polymerization that may also directly mediate signal transduction.
Stevenson, Victoria A. +1 more
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Novel Actin Cytoskeleton. Actin Tubules.
Cell Structure and Function, 2000 In spores of Dictyostelium discoideum three actin filaments are bundled to form a novel tubular structure and the tubules are then organized into rods. These tubular structures we will term actin tubules. Actin tubules are reconstructed from the supernatant of spore homogenates, while the usual actin filaments were bundled after incubation of ...
Masako Osumi +4 more
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The Actin Cytoskeleton and Actin-Based Motility [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 The actin cytoskeleton-a collection of actin filaments with their accessory and regulatory proteins-is the primary force-generating machinery in the cell. It can produce pushing (protrusive) forces through coordinated polymerization of multiple actin filaments or pulling (contractile) forces through sliding actin filaments along bipolar filaments of ...
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Wnt signalling and the actin cytoskeleton [PDF]
Oncogene, 2006 The tumour suppressor adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours. APC binds to beta-catenin, a key component of the Wnt signalling pathway, and induces its degradation. In addition to this role, there is increasing evidence for additional roles of APC, including the organization of cytoskeletal networks. APC
Yoshihiro Kawasaki, Tetsu Akiyama
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