Results 11 to 20 of about 21,210,719 (287)
Activin A in Mammalian Physiology. [PDF]
Physiological Reviews, 2019 Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins.
E. Bloise +5 more
semanticscholar +4 more sources
Structure and activation of pro-activin A [PDF]
Nature Communications, 2016 Activins are growth factors with multiple roles in the development and homeostasis. Like all TGF-β family of growth factors, activins are synthesized as large precursors from which mature dimeric growth factors are released proteolytically.
Xuelu Wang, G. Fischer, M. Hyvönen
semanticscholar +6 more sources
Serum levels of Activin A: Marker of insulin resistance and cardiovascular risk in prediabetics
Journal of Family Medicine and Primary Care, 2022 Background: A substantial proportion of health burden in diabetic individuals can be attributed to cardiovascular complications. The increasing risk of cardiovascular complications along the spectrum of dysglycemia warrants the need to devise novel ...
Ajay Chauhan +3 more
doaj +1 more source
Activin A regulates activation of mouse neutrophils by Smad3 signalling [PDF]
Open Biology, 2017 Activin A, a member of the transforming growth factor beta superfamily, acts as a pro-inflammatory factor in acute phase response, and influences the pathological progress of neutrophil-mediated disease.
Yan Qi +5 more
doaj +1 more source
A Novel Signal Peptide Derived from Bacillus Licheniformis α-Amylase Efficiently Targets Recombinant Human Activin A to the Periplasm of Escherichia coli [PDF]
Journal of Cell and Molecular Research, 2018 Human activin A is a member of the transforming growth factor-β superfamily consists of two similar beta subunits. Activin A is expressed by different cells and displays numerous biological activities such as control of neuronal cell proliferation and ...
Zahra Hajihassan +2 more
doaj +1 more source
Activin A backs-up TGF-ß to promote regulatory T cells
OncoImmunology, 2021 The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by ...
Mara De Martino +2 more
doaj +1 more source
Activin-A: active in inflammation in COPD [PDF]
European Respiratory Journal, 2014 Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow limitation in which chronic inflammation of the airways plays a major role. The persistent inflammation is triggered by inhaled toxic substances, such as cigarette smoke.
Tania, Navessa P. +2 more
openaire +2 more sources
Different Immunoregulation Roles of Activin A Compared With TGF-β
Frontiers in Immunology, 2022 Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also
Fanglin Li +10 more
doaj +1 more source
Scientific Reports, 2020 Colorectal cancer (CRC) is the second deadliest cancer in the US due to its propensity to metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical biophysical role in cancer progression, but the precise pro-metastatic
J. Bauer +8 more
semanticscholar +1 more source
An Easy And Fast Method For Production Of Chinese Hamster Ovary Cell Line Expressing And Secreting Human Recombinant Activin A [PDF]
Cell Journal, 2020 Objective Growth factors are key elements of embryonic stem cell (ESC) research. Cell line development in eukaryotes is a time-consuming procedure which usually takes 12-18 months. Here, we report an easy and fast method with which production of Chinese
Hassan Rassouli +5 more
doaj +1 more source