Results 21 to 30 of about 21,210,719 (287)

Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Among the major health challenges for astronauts during prolonged space travel are loss of muscle mass and loss of bone mass. Here, we investigated the effects of targeting the signaling pathway mediated by the secreted signaling molecules ...
Se-Jin Lee, A. Lehar, J. Meir, C. Koch, Andrew Morgan, L. E. Warren, Renata Rydzik, D. Youngstrom, Harshpreet Chandok, J. George, Joseph Gogain, M. Michaud, T. Stoklasek, Yewei Liu, Emily L. Germain-Lee   +14 more
semanticscholar   +1 more source

Activin B promotes the initiation and progression of liver fibrosis

Hepatology Communications, 2022
The role of activin B, a transforming growth factor β (TGFβ) superfamily cytokine, in liver health and disease is largely unknown. We aimed to investigate whether activin B modulates liver fibrogenesis.
Yan Wang, Matthew Hamang, Alexander Culver, Huaizhou Jiang, Jennifer Yanum, Veronica Garcia, Joonyong Lee, Emily White, Praveen Kusumanchi, Naga Chalasani, Suthat Liangpunsakul, Benjamin C. Yaden, Guoli Dai   +12 more
doaj   +1 more source

Activin A and activin receptors in gestational tissue from preeclamptic pregnancies [PDF]

Journal of Endocrinology, 2001
Maternal serum activin A levels are elevated in women with preeclampsia. To explore whether this could be due, at least in part, to increased production by the gestational tissues, we have measured activin A in the serum of women with (n=23) or without preeclampsia (n=62) at 29-40 weeks of gestation and in placenta and fetal membranes from preterm ...
U, Manuelpillai, M, Schneider-Kolsky, A, Dole, E M, Wallace   +3 more
openaire   +2 more sources

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

eLife, 2020
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC).
S. Aykul, R. A. Corpina, Erich J. Goebel, C. Cunanan, Alexandra Dimitriou, Hyonjong Kim, Qian Zhang, A. Rafique, Raymond Leidich, Xin Wang, J. McClain, Johanna Jimenez, Kalyan C. Nannuru, Nyanza J. Rothman, John B. Lees-Shepard, E. Martinez-Hackert, A. Murphy, T. Thompson, A. Economides, V. Idone   +19 more
semanticscholar   +1 more source

Cripto forms a complex with activin and type II activin receptors and can block activin signaling [PDF]

Proceedings of the National Academy of Sciences, 2003
Activin, nodal, Vg1, and growth and differentiation factor 1 are members of the transforming growth factor β superfamily and signal via the activin type II (ActRII/IIB) and type I (ALK4) serine/threonine kinase receptors. Unlike activins, however, signaling by nodal, Vg1, and growth and differentiation factor 1 requires a coreceptor from the epidermal ...
Peter C, Gray, Craig A, Harrison, Wylie, Vale   +2 more
openaire   +2 more sources

Effect of activin A on migration and adhesion of breast cancer 4T1 cells

Zhongguo gonggong weisheng, 2023
ObjectiveTo explore the effect of activin A on the migration and adhesion of murine breast cancer 4T1 cells. MethodsThe viability of in vitro cultured 4T1 cells was studied using the 3- (4,5-dimethyl-2-thiazyl)-2,5-diphenyl-2h-tetrazolium bromide (MTT ...
Linjing ZHU, Yunlong ZHAO, Shumi SHANG, Fang FANG, Hongyu WANG, Yujia ZOU, Xueling CUI   +6 more
doaj   +1 more source

An Activin-A/C Chimera Exhibits Activin and Myostatin Antagonistic Properties [PDF]

Journal of Biological Chemistry, 2005
Activins are involved in many physiological and pathological processes and, like other members of the transforming growth factor-beta superfamily, signal via type II and I receptor serine kinases. Ligand residues involved in type II receptor binding are located in the two anti-parallel beta strands of the TGF-beta proteins, also known as the fingers ...
Uwe, Muenster, Craig A, Harrison, Cynthia, Donaldson, Wylie, Vale, Wolfgang H, Fischer   +4 more
openaire   +2 more sources

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Role of stromal activin A in human pancreatic cancer and metastasis in mice

Scientific Reports, 2021
Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been implicated in colon cancer and its stroma but its role in the stroma of PDAC has not been ...
Georgina Mancinelli, Carolina Torres, Nancy Krett, Jessica Bauer, Karla Castellanos, Ron McKinney, David Dawson, Grace Guzman, Rosa Hwang, Sam Grimaldo, Paul Grippo, Barbara Jung   +11 more
doaj   +1 more source

A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

EMBO Molecular Medicine, 2020
Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs.
M. Cangkrama, Mateusz S. Wietecha, Nicolas Mathis, Rin Okumura, L. Ferrarese, D. Al-Nuaimi, M. Antsiferova, R. Dummer, M. Innocenti, S. Werner   +9 more
semanticscholar   +1 more source