Downregulation of Organ-Derived Activin A Attenuates Muscle Atrophy and Intramuscular Fat Infiltration in Cancer Cachexia Mice. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Cancer cachexia is a multifactorial wasting syndrome marked by profound skeletal muscle loss. Tumours can release high levels of Activin A (ActA), which activates the ubiquitin‐proteasome pathway (UPP) and drives muscle wasting.
Wang C +14 more
europepmc +2 more sources
Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. [PDF]
PLoS ONE, 2015 Deregulated expression of activin A is reported in several tumors, but its biological functions in oral squamous cell carcinoma (OSCC) are unknown. Here, we investigate whether activin A can play a causal role in OSCCs.
Andreia Bufalino +14 more
doaj +1 more source
Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide [PDF]
Endocrinology, 2011 Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased tissues.
Yogeshwar, Makanji +5 more
openaire +2 more sources
Czech Journal of Animal Science, 2010 To improve the culture system of bovine somatic cell nuclear transfer (SCNT) embryos, we studied the effects of activin A on developmental competence of bovine SCNT embryos during the early development stage based on the traditional culture method, and ...
S. Hua +7 more
doaj +1 more source
Effect of activin A on migration and adhesion of breast cancer 4T1 cells
Zhongguo gonggong weisheng, 2023 ObjectiveTo explore the effect of activin A on the migration and adhesion of murine breast cancer 4T1 cells. MethodsThe viability of in vitro cultured 4T1 cells was studied using the 3- (4,5-dimethyl-2-thiazyl)-2,5-diphenyl-2h-tetrazolium bromide (MTT ...
Linjing ZHU +6 more
doaj +1 more source
The mechanical stimulation of myotubes counteracts the effects of tumor-derived factors through the modulation of the activin/follistatin ratio [PDF]
, 2019 Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Adamo, Sergio +8 more
core +1 more source
Role of stromal activin A in human pancreatic cancer and metastasis in mice
Scientific Reports, 2021 Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been implicated in colon cancer and its stroma but its role in the stroma of PDAC has not been ...
Georgina Mancinelli +11 more
doaj +1 more source
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]
, 2015 BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi +9 more
core +2 more sources
Urinary Activin A: A Novel Biomarker for Human Acute Kidney Injury
Diagnostics, 2022 Activin is a multifunctional cytokine belonging to the transforming growth factor (TGF)-β superfamily that regulates the growth and differentiation of cells in various organs.
Izumi Nagayama +2 more
doaj +1 more source
Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]
, 2018 The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
core +2 more sources