Results 31 to 40 of about 21,210,719 (287)

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Myostatin and activin A are secreted signaling molecules that act to limit skeletal muscle growth. Here, we show that myostatin and activin A utilize four receptor components to signal directly to muscle fibers.
Se-Jin Lee, A. Lehar, Yewei Liu, Chi Ly, Quynh-Mai Pham, M. Michaud, Renata Rydzik, D. Youngstrom, M. Shen, V. Kaartinen, Emily L. Germain-Lee, T. Rando   +11 more
semanticscholar   +1 more source

Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide [PDF]

Endocrinology, 2011
Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased tissues.
Yogeshwar, Makanji, Kelly L, Walton, Karen L, Chan, Paul, Gregorevic, David M, Robertson, Craig A, Harrison   +5 more
openaire   +2 more sources

Recombinant human activin A promotes development of bovine somatic cell nuclear transfer embryos matured in vitro

Czech Journal of Animal Science, 2010
To improve the culture system of bovine somatic cell nuclear transfer (SCNT) embryos, we studied the effects of activin A on developmental competence of bovine SCNT embryos during the early development stage based on the traditional culture method, and ...
S. Hua, J. Lan, Y.G. Liu, Y.L. Song, J. Liu, Y.S. Wang, T. Zhang, Y. Zhang   +7 more
doaj   +1 more source

Urinary Activin A: A Novel Biomarker for Human Acute Kidney Injury

Diagnostics, 2022
Activin is a multifunctional cytokine belonging to the transforming growth factor (TGF)-β superfamily that regulates the growth and differentiation of cells in various organs.
Izumi Nagayama, Akito Maeshima, Daisuke Nagata   +2 more
doaj   +1 more source

The mechanical stimulation of myotubes counteracts the effects of tumor-derived factors through the modulation of the activin/follistatin ratio [PDF]

, 2019
Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Adamo, Sergio, Baccam, Alexandra, Benoni-Sviercovich, Alexandra, Coletti, Dario, Li, Zhenlin, Moresi, Viviana, Rocchi, Marco, Seelaender, Marilia, Xue, Zhigang   +8 more
core   +1 more source

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]

, 2015
BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi, Bauer, Jessica, Carroll, Timothy, Eckmann, Lars, Grippo, Paul J, Jung, Barbara, Ozden, Ozkan, Principe, Daniel R, Spehlmann, Martina E, Staudacher, Jonas J   +9 more
core   +2 more sources

The effect of Activin A and Steroid Hormones on the Recurrent and single Abortion

Tikrit Journal of Pure Science, 2023
This study is designed to evaluate the relationship between Activin -A and the incidence of recurrent and single abortion. The study also included the Estimate of steroid hormones levels (FSH, LH and progesterone concentration through the abortion and ...
Nazar Ahmed Naji, Galawesh Norri Tahrr
doaj   +1 more source

Combined Treatment of Activin A and Heparin Binding-EGF (HB-EGF) Enhances In Vitro Production of Bovine Embryos

Journal of Animal Reproduction and Biotechnology, 2014
This study was carried out to investigate the effects of tissue inhibitor of matalloproteinase-1 (TIMP-1), Activin A and Heparin binding epidermal growth factor (HB-EGF) on In Vitro production of bovine embryos.
Se-woong Kim, Yeon-Gil Jung, Jong-im Park, Sangho Roh   +3 more
doaj   +1 more source

The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes

Frontiers in Endocrinology, 2022
Activin A, a TGFβ superfamily member, is important for normal testis development through its actions on Sertoli cell development. Our analyses of altered activin A mouse models indicated gonocyte abnormalities, implicating activin A as a key determinant ...
Sarah C. Moody, Sarah C. Moody, Penny A. F. Whiley, Penny A. F. Whiley, Patrick S. Western, Patrick S. Western, Kate L. Loveland, Kate L. Loveland   +7 more
doaj   +1 more source