Results 41 to 50 of about 21,210,719 (287)

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells [PDF]

, 2012
Peer reviewedPublisher ...
A Kubo, AK Teo, C. H.-H. Cho, D Zhang, E Kroon, E Wandzioch, F. M. Docherty, H Li, H. M. Docherty, IG Brons, J Ameri, J Cai, J Jonsson, JA Thomson, JF Habener, JK Mfopou, JM Wells, JR Spence, K Takahashi, K. Docherty, KA D’Amour, KA Harrison, KS Zaret, L Vallier, L Vallier, L. Vallier, M Inamura, M Polak, M. Joåo Lima, M. W. B. Trotter, MC Nostro, MF Offield, N. R.-F. Hannan, OG Kelly, R Bort, R Maehr, RI Sherwood, S Brown, ST Rashid, T Touboul, V Ramos-Mejia, W Jiang, Y Kunisada   +42 more
core   +2 more sources

Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer

Cancer immunology research, 2020
Activin A and TGFβ can shape the breast cancer tumor microenvironment after radiotherapy. Dual blockade of activin A and TGFβ reverses radiotherapy-induced Treg increases and boosts antitumor responses, highlighting potential targetable factors for ...
M. De Martino, C. Daviaud, J. Diamond, J. Kraynak, A. Alard, S. Formenti, L. Miller, S. Demaria, C. Vanpouille-Box   +8 more
semanticscholar   +1 more source

Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]

, 2017
BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J, Hoffmann, Hanne M, Iyer, Anita K, Mellon, Pamela L, Ngo, Cindy, Sunshine, Mary Jean, Xie, Huimin   +6 more
core   +3 more sources

Activin-A in the regulation of immunity in health and disease.

Journal of Autoimmunity, 2019
The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially identified
I. Morianos, G. Papadopoulou, M. Semitekolou, G. Xanthou   +3 more
semanticscholar   +1 more source

Activin A determines steroid levels and composition in the fetal testis.

Endocrinology, 2020
Activin A promotes fetal mouse testis development, including by driving Sertoli cell proliferation and cord morphogenesis, but its mechanisms of action are undefined.
P. Whiley, L. O’Donnell, Sarah C. Moody, David Handelsman, Julia C. Young, Elizabeth A Richards, K. Almstrup, P. Western, K. Loveland   +8 more
semanticscholar   +1 more source

Anti-activin A Antibody (IgY) Specifically Neutralizes Various Activin A Activities

Experimental Biology and Medicine, 1996
Activin A (beta A beta A), originally isolated from ovarian follicular fluids as a follicule-stimulating hormone (FSH) secretion stimulator, has also been identified as an erythroid differentiation factor (EDF), a neuron survival factor and a mesoderm-inducing factor. Thus, activin A is a multifunctional factor, and further studies on its physiological
T, Murata, S, Saito, M, Shiozaki, R Z, Lu, Y, Eto, M, Funaba, M, Takahashi, K, Torii   +7 more
openaire   +2 more sources

Activin A and Betacellulin [PDF]

Diabetes, 2004
Activin A and betacellulin (BTC) are thought to regulate differentiation of pancreatic β-cells during development and regeneration of β-cells in adults. In the present study, we used neonatal rats treated with streptozotocin (STZ) to investigate the effects of activin A and BTC on regeneration of pancreatic β-cells. One-day-old Sprague-Dawley rats were
Lei Li, Zhaohong Yi, Masaharu Seno, Itaru Kojima   +3 more
openaire   +1 more source

Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis [PDF]

, 2017
This work was supported by British Heart Foundation (BHF Project Grant no PG/13/23/30080 to B.A.A and S.H.), Biotechnology and Biological Sciences Research Council (BB/M001695/1 to S.H.) and the University of Aberdeen (for A.T.L).
Afouda, Boni A, De Paiva Alves, Eduardo, Hoppler, Stefan, Lynch, Adam T   +3 more
core   +1 more source

Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway

Cell Communication and Signaling, 2019
Endometriosis, characterized by the presence of functional endometrial tissues outside the uterus, is one of the most common gynecological disorders.
Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu, G. Wan, Xiaodong Han   +7 more
semanticscholar   +1 more source

Activin A directly impairs human cardiomyocyte contractile function indicating a potential role in heart failure development

Frontiers in Cardiovascular Medicine, 2022
Activin A has been linked to cardiac dysfunction in aging and disease, with elevated circulating levels found in patients with hypertension, atherosclerosis, and heart failure.
Scott MacDonnell, Jake Megna, Qin Ruan, Olivia Zhu, Gabor Halasz, Dan Jasewicz, Kristi Powers, Hock E, Maria del Pilar Molina-Portela, Ximei Jin, Dongqin Zhang, Justin Torello, Nicole T. Feric, Michael P. Graziano, Akshay Shekhar, Michael E. Dunn, David Glass, Lori Morton   +17 more
doaj   +1 more source