Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis [PDF]
, 2017 This work was supported by British Heart Foundation (BHF Project Grant no PG/13/23/30080 to B.A.A and S.H.), Biotechnology and Biological Sciences Research Council (BB/M001695/1 to S.H.) and the University of Aberdeen (for A.T.L).
Afouda, Boni A +3 more
core +1 more source
Journal of Cachexia, Sarcopenia and Muscle, 2019 Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.
Xiaoling Zhong +16 more
doaj +1 more source
Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer
Biomedicines, 2021 Activin, a member of the TGF-β superfamily, is involved in many physiological processes, such as embryonic development and follicle development, as well as in multiple human diseases including cancer.
Wanglong Qiu +3 more
doaj +1 more source
Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells [PDF]
, 1997 To gain more insight in the mechanism of action of inhibin, we studied the effect of inhibin on activin signaling in Chinese hamster ovary cells.
Jong, F.H. (Frank) de +6 more
core +3 more sources
Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]
, 2006 The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J. +8 more
core +2 more sources
N-myc Down-Regulates Activin A
Biochemical and Biophysical Research Communications, 2000 N-myc oncogene amplification is frequent in human neuroblastoma and predicts poor prognosis, but the molecular consequences have remained obscure. We report here that enhanced N-myc expression correlates with low or undetectable expression of activin A, but not other closely related members of the transforming growth factor-beta superfamily.
Breit, Stephen +3 more
openaire +4 more sources
Activin A and pathologies of pregnancy: a review
Placenta, 2023 Activin A is a two-subunit protein belonging to the transforming growth factor β superfamily. First discovered almost three decades ago, it has since been implicated in diverse physiological roles, ranging from wound repair to reproduction. After 30 years of research, altered activin A levels are now understood to be associated with the development of ...
Courtney V. Barber +5 more
openaire +2 more sources
Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells [PDF]
, 1999 Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression
Achterberg, T.A.E. (Tanja) van +6 more
core +3 more sources
Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. [PDF]
, 2014 We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pituitary ...
Barakat, Nermeen H +7 more
core +1 more source
Comparison of bioactivities, binding properties and intra-follicular levels of bovine follistatins [PDF]
, 2015 Five isoforms of follistatin (FST) (Mr 31, 33, 35, 37, 41kDa) were purified from bovine follicular fluid (bFF). Comparison of their activin- and heparan sulphate proteoglycan (HSP)-binding properties and bio-potencies in neutralization of activin-A ...
Boland, Maurice P. +4 more
core +1 more source