In vitro and in silico insights on the regulation by gonadal hormones of pituitary GnRH receptor expression in a basal teleost, the European eel [PDF]
Frontiers in EndocrinologyEel species are basal teleosts with a unique life cycle including an arrest of sexual maturation before the reproductive oceanic migration. Our early studies showed that this blockade results from a deficient production of pituitary gonadotropins, due in
Chien-Ju Lin +5 more
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Activins and Inhibins in Cardiovascular Pathophysiology [PDF]
BiomoleculesActivins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were initially recognized for their opposing effects on the secretion of follicle-stimulating hormone.
Wenyi Tang +6 more
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Differential expression of follistatin and FLRG in human breast proliferative disorders [PDF]
BMC Cancer, 2009 Background Activins are growth factors acting on cell growth and differentiation. Activins are expressed in high grade breast tumors and they display an antiproliferative effect inducing G0/G1 cell cycle arrest in breast cancer cell lines.
Amaral Vania F +11 more
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Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy [PDF]
OncoImmunologyActivins, members of the TGF-beta superfamily, have been isolated and identified in the endocrine system, but have not been substantially investigated in the context of the immune system and endocrine-unrelated cancers.
Ying Zheng +9 more
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Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model. [PDF]
PLoS ONE, 2017 Fractures still present a significant burden to patients due to pain and periods of unproductivity. Numerous growth factors have been identified to regulate bone remodeling.
Tero Puolakkainen +6 more
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TGF-β Signaling in the Pathophysiology of the Ovary: A Double-Edged Regulator [PDF]
BiomoleculesThe Transforming Growth Factor-β (TGF-β) superfamily comprises highly conserved cytokines that orchestrate key cellular functions, including proliferation, differentiation, and apoptosis. Within the ovary, TGF-β family members serve as pivotal regulators
Nicole Bertani +11 more
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Drosophila activins adapt gut size to food intake and promote regenerative growth [PDF]
Nature CommunicationsRapidly renewable tissues adapt different strategies to cope with environmental insults. While tissue repair is associated with increased intestinal stem cell (ISC) proliferation and accelerated tissue turnover rates, reduced calorie intake triggers a ...
Christian F. Christensen +4 more
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Treatment Paradigm Shifts in Pulmonary Arterial Hypertension [PDF]
JACC: AsiaWen Wen, MD, Yunshan Cao, MD, PhD
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Activin Actions in Adipocytes.
J Clin Endocrinol MetabAbstract Obesity is a growing global health problem characterized by excess fat accumulation. Though causes of obesity are multifactorial, glucagon-like peptide 1 receptor agonists have emerged as effective weight loss drugs. Nevertheless, these agents are expensive, not uniformly available, and must be used continuously.
Ongaro L, Bernard DJ.
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Cells, 2021 Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting ...
Juha J. Hulmi +3 more
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