Results 21 to 30 of about 20,228 (237)
Activins, follistatin and immunoregulation in the epididymis
Andrology, 2019 The interface between the epididymis and the immune system is implicated in many male reproductive pathologies. The resident immune cell populations and immune‐environment within the epididymis are significantly different from the testis, which is an ...
R. Wijayarathna +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 Human immunodeficiency virus type 1 (HIV-1) infection triggers rapid induction of multiple innate cytokines including type I interferons, which play important roles in viral control and disease pathogenesis.
Matthew Dickinson +10 more
doaj +1 more source
Follistatin as potential therapeutic target in prostate cancer [PDF]
, 2013 Follistatin is a single-chain glycosylated protein whose primary function consists in binding and neutralizing some members of the transforming growth factor-β superfamily such as activin and bone morphogenic proteins.
CRESCIMANNO, Marilena +7 more
core +1 more source
Activin signaling as an emerging target for therapeutic interventions
Cell Communication and Signaling, 2009 After the initial discovery of activins as important regulators of reproduction, novel and diverse roles have been unraveled for them. Activins are expressed in various tissues and have a broad range of activities including the regulation of gonadal ...
Ageta Hiroshi +6 more
doaj +1 more source
Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]
, 2018 The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
core +2 more sources
Journal of Clinical Endocrinology and Metabolism, 2018 Context Clinical trials are evaluating the efficacy of inhibitors of the myostatin pathway in neuromuscular and metabolic diseases. Activins and follistatins are major regulators of the myostatin pathway, but their physiology in relation to metabolic and
N. Perakakis +7 more
semanticscholar +1 more source
Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan
International Journal of Inflammation, 2014 Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin ...
Jun Yamada +7 more
doaj +1 more source
Follistatin attenuates radiation-induced fibrosis in a murine model. [PDF]
PLoS ONE, 2017 PURPOSE:Fibrosis can be a disabling, severe side effect of radiotherapy that can occur in patients, and for which there is currently no effective treatment.
Helen B Forrester +4 more
doaj +1 more source
The vegetalizing factor A member of the evolutionarily highly conserved activin family [PDF]
, 1992 The mesoderm and endoderm inducing vegetalizing factor was partially sequenced after BrCN cleavage. A sequence which is highly conserved in activin A near the C-terminal end was identified. This shows that the factor belongs to the activin family.
Geithe +35 more
core +1 more source
Is telomerase reactivation associated with the down-regulatoin of TGFβ receptor-II expression in human breast cancer? [PDF]
, 2003 Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells. TGF beta (
Elkak, AE +3 more
core +3 more sources