Physiological roles of activins in the human ovary
Journal of Bio-X Research, 2018 . Initially discovered in the pituitary as stimulators of follicle stimulating hormone, activins are homo- or heterodimers of inhibin subunits, which belong to the transforming growth factor-β superfamily.
Hsun-Ming Chang, Peter C.K. Leung
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Follistatin attenuates radiation-induced fibrosis in a murine model. [PDF]
PLoS ONE, 2017 PURPOSE:Fibrosis can be a disabling, severe side effect of radiotherapy that can occur in patients, and for which there is currently no effective treatment.
Helen B Forrester +4 more
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Activin/TGFβ and BMP crosstalk determines digit chondrogenesis [PDF]
, 2008 The progress zone (PZ) is a specialized area at the distal margin of the developing limb where mesodermal cells are kept in proliferation and undifferentiated, allowing limb outgrowth.
1000010205429 +5 more
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Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation. [PDF]
PLoS ONE, 2016 Lung transplantation exposes the donated lung to a period of anoxia. Re-establishing the circulation after ischemia stimulates inflammation causing organ damage.
David M de Kretser +7 more
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iScience, 2021 Summary: Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in patients.
Takayuki Ozawa +7 more
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Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer [PDF]
, 2016 BACKGROUND: Activin-A may exert pro- or anti-tumorigenic activities depending on cellular context. However, little is known about its role, or the other mature activin proteins, in colorectal carcinoma (CRC). This study measured the expression of activin
Adel Galal El-Shemi +5 more
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Expressão de proteínas SMAD, mediadores da sinalização de TGF-beta/activina, em tecidos de tiroide humana [PDF]
, 2010 OBJECTIVE: To investigate the expression of SMAD proteins in human thyroid tissues since the inactivation of TGF-β/activin signaling components is reported in several types of cancer.
EBINA, Kátia N. +7 more
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BMC Biology, 2022 Background Activins and bone morphogenetic proteins (BMPs) play critical, sometimes opposing roles, in multiple physiological and pathological processes and diseases.
Szabina Szófia Szilágyi +4 more
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The orphan ligand, activin C, signals through activin receptor-like kinase 7
eLife, 2022 Activin ligands are formed from two disulfide-linked inhibin β (Inhβ) subunit chains. They exist as homodimeric proteins, as in the case of activin A (ActA; InhβA/InhβA) or activin C (ActC; InhβC/InhβC), or as heterodimers, as with activin AC (ActAC ...
Erich J Goebel +8 more
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TLR3 Deficiency Leads to a Dysregulation in the Global Gene-Expression Profile in Murine Oviduct Epithelial Cells Infected with Chlamydia muridarum [PDF]
, 2019 OBJECTIVE Describe the implementation and effects of Mobile Acute Care for Elders (MACE) consultation at a Veterans Affairs Medical Center (VAMC). DESIGN Retrospective cohort analysis.
Derbigny, Wilbert A, Kumar, Ramesh
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