Results 41 to 50 of about 8,029 (232)

Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy [PDF]

, 2017
Background: Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle degeneration and also high ...
Heikinheimo, Kristiina, Hulmi, Juha, Kainulainen, Heikki, Kiviranta, Riku, Ma, Hongqian, Pasternack, Arja, Puolakkainen, Tero, Rantalainen, Timo, Ritvos, Olli   +8 more
core   +1 more source

Structure and activation of pro-activin A

Nature Communications, 2016
Activins are members of the TGF-β family of growth factors that are processed from precursors into the mature proteins. Here, the authors use structural biology and biochemistry to examine the protein domain organisation and gain insights into the ...
Xuelu Wang, Gerhard Fischer, Marko Hyvönen   +2 more
doaj   +1 more source

The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis [PDF]

, 2012
Recent data from the AZURE, ABCSG-12, and ZO-FAST clinical trials have challenged our understanding of the potential anticancer activity of zoledronic acid (ZOL). Although the results of these studies may appear to be conflicting on the surface, a deeper
Arrington, Avcu, Baum, Bilezikjian, Binkley, Bismar, Black, Bourdeau, Brown, Bundred, Burger, Burger, Centrella, Chapman, Cheleuitte, Chiu, Clowes, Coleman, Coscia, Coxon, Croucher, de Boer, Del Mastro, Dixon, Duivenvoorden, Edlund, Edlund, Esparza-Lopez, Folkerd, Gasser, Gasser, Geisler, Giraudo, Gnant, Gnant, Gnant, Gnant, Gordon, Guo, Hackshaw, Hamilton, Hampl, Hershman, Hershman, Hines, Hiraga, Hofbauer, Hornby, Ibrahim, Jimenez-Gordo, Juarez, Kaplan, Kaplan, Kardassis, Khosla, Kirkbride, Labrinidis, Le Goff, Lee, Lewis, Lindberg, Little, Little, Meads, Melani, Monkkonen, Muller, Nicks, Ogata, Ottewell, Ottewell, Ottewell, Pataki, Perrien, Perrien, Peyruchaud, Pfeilschifter, Podworny, Rachner, Rannevik, Roelofs, Rogers, Rosen, Rosen, Saika, Sasser, Sasser, Shiozawa, Shipman, Sims, Sirola, Skerjanec, Sowers, Studebaker, Sun, Tang, Thompson, Thurlimann, Uncu, van de Velde, Weiss, Wels, Welt, Wiater, Winter   +104 more
core   +1 more source

Immunolocalization of activin and inhibin at different stages of follicular development in the lizard Sceloporus torquatus

Heliyon, 2023
The activins and inhibins are glycoproteins with a role in the follicular development of vertebrates, that are found in follicular fluid and somatic follicular cells, with a different pattern among taxa.
N.B. Cruz-Cano, U.Á. Sánchez-Rivera, C. Álvarez-Rodríguez, R.E. Loya-Zurita, Y.J. Castro-Camacho, M. Martínez-Torres   +5 more
doaj   +1 more source

Recognizing menopause in women with amenorrhea induced by cytotoxic chemotherapy for endocrine-responsive early breast cancer. [PDF]

, 2012
Cytotoxic anticancer treatment may induce amenorrhea or menopause to a variable extent. These side effects may not only impair or impede fertility but also cause sexual dysfunction, bone loss, and menopausal symptoms, with a strikingly negative effect on
Appetecchia, M, Barnabei, A, Corsello, SM., De Vecchis, L, Strigari, L, Torino, F   +5 more
core   +1 more source

Phase 3, Open-Label Multicenter Study of Sotatercept in Japanese Participants With Pulmonary Arterial Hypertension

JACC: Asia
Background: Sotatercept is a first-in-class activin signaling inhibitor, developed for the treatment of pulmonary arterial hypertension (PAH). Objectives: This open-label single-arm, multicenter, phase 3 study was initiated to evaluate the efficacy and ...
Hiromi Matsubara, MD, PhD, Nobuhiro Tanabe, MD, PhD, Takeshi Ogo, MD, PhD, Kohtaro Abe, MD, PhD, Takumi Inami, MD, PhD, Yuko Maeda, PhD, Ichiro Arano, PhD, Masayoshi Shirakawa, MSc, Ryosuke Sakai, MSc, Alexandra G. Cornell, MD, MCR, Ichizo Tsujino, Nobuhiro Yaoita, Toshihiko Sugiura, Nobuhiro Tanabe, Takumi Inami, Masaru Hatano, Takahiro Hiraide, Yuichi Tamura, Shiro Adachi, Takeshi Ogo, Yu Taniguchi, Hiromi Matsubara, Nobuhiro Tahara, Kohtaro Abe, Hiroshi Watanabe, Yoshihiro Dohi, Akiyoshi Hashimoto   +26 more
doaj   +1 more source

Serum Activins and Follistatin during the Treatment of Chronic Hepatitis C Genotypes 1 and 4 and Their Correlations with Viral Load and Liver Enzymes: A Preliminary Report

Gastroenterology Research and Practice, 2014
Aims. To measure the effect of pegylated interferon-α therapy on serum activin-A, activin-B, and follistatin and their correlation with viral load and liver fibrosis in chronic hepatitis C (CHC). Methods.
Bassem Refaat, Adel Galal El-Shemi, Ahmed Mohamed Ashshi, Adnan AlZanbagi   +3 more
doaj   +1 more source

Activin/Nodal signalling in stem cells. [PDF]

, 2015
Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis.
Pauklin, Siim, Vallier, Ludovic
core   +2 more sources

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Prognostic value of activin A level in patients with advanced lung cancer and sarcopenia

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The aim of this work is to determine the prognostic role of activin A in patients with advanced lung cancer and sarcopenia. Materials and methods.
V. V. Kechedzhyiev
doaj   +1 more source