Results 61 to 70 of about 20,228 (237)

TGF-β signaling in lymphatic vascular vessel formation and maintenance

Frontiers in Physiology, 2022
Transforming growth factor (TGF)-β and its family members, including bone morphogenetic proteins (BMPs), nodal proteins, and activins, are implicated in the development and maintenance of various organs. Here, we review its role in the lymphatic vascular
Fumiko Itoh, Tetsuro Watabe
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

Journal of Cachexia, Sarcopenia and Muscle, 2019
Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.
Xiaoling Zhong, Marianne Pons, Christophe Poirier, Yanlin Jiang, Jianguo Liu, George E. Sandusky, Safi Shahda, Attila Nakeeb, C. Max Schmidt, Michael G. House, Eugene P. Ceppa, Nicholas J. Zyromski, Yunlong Liu, Guanglong Jiang, Marion E. Couch, Leonidas G. Koniaris, Teresa A. Zimmers   +16 more
doaj   +1 more source

Narrative review: environmental and genetic basis of orofacial clefts.

Journal of Oral Research, 2013
Complex genetic process guides the embryonic head development. Alterations in these processes result in structural abnormalities. An example of these are the cleft lip and palate.
César Rivera, María Jesús Arenas
doaj   +1 more source

Designer TGFβ superfamily ligands with diversified functionality. [PDF]

PLoS ONE, 2011
Transforming Growth Factor--beta (TGFβ) superfamily ligands, including Activins, Growth and Differentiation Factors (GDFs), and Bone Morphogenetic Proteins (BMPs), are excellent targets for protein-based therapeutics because of their pervasiveness in ...
George P Allendorph, Jessica D Read, Yasuhiko Kawakami, Jonathan A Kelber, Michael J Isaacs, Senyon Choe   +5 more
doaj   +1 more source

Activin A: its role and involvement in inflammatory diseases [PDF]

, 2015
Activin proteins are members of the transforming growth factor-β family. Activin A is involved in several biological responses including wound repair, cell death, proliferation and differentiation of many cell types.
Basir, Rusliza, Chuah, Yaw Kuang, Nordin, Norshariza, Talib, Herni, Tie, Tung Hing   +4 more
core  

The mechanical stimulation of myotubes counteracts the effects of tumor-derived factors through the modulation of the activin/follistatin ratio [PDF]

, 2019
Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Adamo, Sergio, Baccam, Alexandra, Benoni-Sviercovich, Alexandra, Coletti, Dario, Li, Zhenlin, Moresi, Viviana, Rocchi, Marco, Seelaender, Marilia, Xue, Zhigang   +8 more
core   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Cancer Treatment and Bone Health [PDF]

, 2018
Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments.
A Falahati-Nini, A Garg, A Lipton, A Llombart, A Morishima, A Tomkinson, AM Brufsky, AR Hong, B Buehring, BF Boyce, BL Clarke, BL Clarke, C Christensen, C Magno, C Poznak Van, C Shapiro, C Wilson, Catherine Handforth, CH Kasperk, CJ Stava, D Goldray, D Vanderschueren, DA Cameron, DA Galvão, DL Hershman, DM Huber, DS Perrien, Early Breast Cancer Trialists, EP Smith, F Mazzuca, FA Trémollieres, GK Ellis, HG Bone, HW Daniell, I Fogelman, I Sestak, J Morote, J Pfeilschifter, J Planas, Janet Brown, JD Wilson, JE Lester, JE Lester, JF Forbes, JL Mohler, JM Bruder, KB Emerton, KM Nicks, L Bošković, L Vehmanen, LC Hofbauer, LC Hofbauer, LH Klotz, LP Fried, M Bauer, M Datta, M Gnant, M Gnant, M Kalder, M Kalder, M Rabaglio, MD Michaelson, MG Oefelein, MM Agarwal, MR Smith, MR Smith, MR Smith, MR Smith, MR Smith, MR Smith, N Majithia, N Napoli, ND James, ND Wagner-Johnston, P Hadji, P Hadji, P Hadji, P Hadji, P Rodrigues, PD Miller, PE Goss, PE Goss, PL Nguyen, R Choo, R Coleman, R Coleman, R Eastell, R Eastell, R Soleimani, RA Adler, RE Coleman, RJ Segal, Robert Coleman, S Dhesy-Thind, S D’Oronzo, SL Greenspan, Stella D’Oronzo, SY Ying, T Kameda, T Liu, T Rana, T Saarto, TA Guise, TH Diamond, TJ Powles, V Carnevale, V Subbiah, VB Shahinian, W Vale, WJ Boyle   +109 more
core   +2 more sources